Research Christmas 2024: Death is Just Around the Corner Alzheimer’s disease mortality among taxi and ambulance drivers: population based cross sectional study Vishal R Patel, Michael Liu, Christopher M Worsham, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-082194 (Published 17 December 2024)Cite this as: BMJ 2024;387:e082194 Abstract Objective To analyze mortality attributed to Alzheimer’s disease among taxi drivers and ambulance driv...

Research Christmas 2024: Seasons of Love Effect of heated mittens on physical hand function in people with hand osteoarthritis: randomised controlled trial Cecilie Bartholdy, Anna Døssing, Zara R Stisen, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2023-078222 (Published 17 December 2024)Cite this as: BMJ 2024;387:e078222 Abstract Objective To assess the effect of electrically heated mittens on physical hand function in people with osteoar...

Clinical Cognition in the Context of Artificial Intelligence In ICU Mon, 5 Aug 2024 Medical decision systems powered by artificial intelligence (AI) are widely used in healthcare. The rapid development and commercialisation of these systems outpace the understanding of their clinical value, creating an "AI chasm." This gap is due to various technical and logistical challenges and issues in clinical implementation.  The relationship between huma...

Original Investigation  Health Policy October 16, 2024 Clinical Benefit, Price, and Regulatory Approval of Cancer Drugs Granted Breakthrough Therapy Designation in China, 2020-2024 Xingxian Luo, Xin Du, Xufeng Lv, et al JAMA Netw Open. 2024;7(10):e2439080. doi:10.1001/jamanetworkopen.2024.39080 Key Points Question  What are the differences in clinical benefit, clinical development time, novel...

HEMOPRED Study: Fluid Responsiveness in ARDS In ICU Mon, 23 Sep 2024 Optimal fluid management in patients with acute respiratory distress syndrome (ARDS) poses significant challenges. A positive fluid balance is linked to extended mechanical ventilation, longer ICU stays, and increased mortality due to increased pulmonary capillary pressure, which exacerbates inflammation and causes alveolar flooding. On the other hand, haemodynamic instability is comm...

Original Investigation  Pediatrics October 16, 2024 In Utero Exposure to Maternal COVID-19 and Offspring Neurodevelopment Through Age 24 Months Eleni G. Jaswa, Heather G. Huddleston, Karla J. Lindquist, et al JAMA Netw Open. 2024;7(10):e2439792. doi:10.1001/jamanetworkopen.2024.39792 Key Points Question  Is exposure to maternal SARS-CoV-2 infection in utero associated with increased risk for ...

Editorial  December 10, 2024 Do Sepsis Alerts Help? Derek C. Angus JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25818 A great hope of moving from paper to electronic health records (EHRs) is that health data could be scanned in real-time, alerting the care team of potential gaps in care before untoward consequences occur. While leveraging this type of case-specific clinical decision support could dramatically improve the qu...

Editorial  December 10, 2024 Reevaluating Respiratory Support in Acute Respiratory Failure—Insights From the RENOVATE Trial and Implications for Practice Yonathan Freund, Amelie Vromant JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25869 There is a fundamental question in emergency medicine: Is high-flow nasal oxygen an appropriate alternative to noninvasive ventilation across varied presentations of acute respiratory failur...

ORIGINAL ARTICLE Safety of Kidney Transplantation from Donors with HIV Christine M. Durand, Allan Massie, Ph.D., Sander Florman, et al N Engl J Med 2024;391:1390-1401 Abstract BACKGROUND Kidney transplantation from donors with human immunodeficiency virus (HIV) to recipients with HIV is an emerging practice. It has been performed since 2016 under the U.S. congressional HIV Organ Policy Equity Act and is currently approved for research only. The Departmen...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial Yaseen M. Arabi, Abdulmohsen Alsaawi, Mohammed Alzahrani, et al JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25982 Key Points Question  Does electronic sepsis screening based on quick ...