Digital Twins of Acute Hypoxaemic Respiratory Failure and Noninvasive Ventilation In ICU Mon, 16 Sep 2024 Noninvasive ventilation (NIV) is increasingly used to assist spontaneous breathing in patients with acute hypoxaemic respiratory failure (AHRF) and can reduce the need for intubation, mortality, and ICU stay. However, if NIV fails, it can increase mortality if intubation is necessary, and high respiratory effort not controlled by NIV might cause ad...

Research Dexterity assessment of hospital workers: prospective comparative study Tobin Joseph, Oliver I Brown, Sara Khalid, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-081814 (Published 20 December 2024)Cite this as: BMJ 2024;387:e081814 Abstract Objectives To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game.  Design Prospective, observational, comparativ...

COMMENT REVISITing treatment of metallo-β-lactamases Emily L Heil, Erin K McCreary Lancet Infect Dis 2024 Online first October 07, 2024 https://doi.org/10.1016/S1473-3099(24)00561-9 Metallo-β-lactamase enzymes, named because of the presence of one or two zinc ions at the catalytic site, are responsible for β-lactam antibiotic hydrolysis and are increasing in prevalence worldwide.1 Despite the increase in antibiotic development over the past decade, a β...

Feature Christmas 2024 How to transport a polar bear, and other idiosyncrasies in providing emergency medical services in the Arctic Astrid K V Harring, Siri Idland, Mari Mowe Martinsen, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2417 (Published 18 December 2024)Cite this as: BMJ 2024;387:q2417 Emergency helicopters in Norway’s northern Svalbard archipelago sometimes take unusual passengers, write Astrid K V Harring and colleagues Six h...

Editorials Just-in-time training could be just what the doctor ordered Justine M Naylor BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2747 (Published 16 December 2024)Cite this as: BMJ 2024;387:q2747 A new approach for teaching clinical skills At the heart of the practice of medicine is the tenet “to do good or to do no harm.”1 Fundamental to achieving this objective is continuing professional development (CPD), which should be lifelong and learner-c...

Metabolomics and Pulmonary and Critical Care Medicine In ICU Mon, 23 Sep 2024 Over the past two decades, systems biology has made significant progress, with metabolomics emerging as the latest field. Metabolomics involves the systematic study of metabolites, which reflect the physiological state of a biological system. This field has been applied to various disciplines, including pulmonary and critical care medicine. Metabolomics provides insights i...

Research Christmas 2024: Could We Start Again, Please? Coaching inexperienced clinicians before a high stakes medical procedure: randomized clinical trial Stephen G Flynn, Raymond S Park, Anupam B Jena, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-080924 (Published 16 December 2024)Cite this as: BMJ 2024;387:e080924 Abstract Objective To assess whether training provided to an inexperienced clinician just before performing a high stake...

Feature Christmas 2024: For Forever Living happily ever after? The hidden health risks of Disney princesses Sanne H B van Dijk, Michael Bui, Anouk H Eijkelboom BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2497 (Published 16 December 2024)Cite this as: BMJ 2024;387:q2497 While much current research on Disney princesses focuses on the harmful impact of unrealistic ideals on young viewers’ self-esteem, there is a critical need to shift attention towards t...

Prevalence, Mortality of Sepsis Using Adult Sepsis Event In Sepsis Mon, 5 Aug 2024 Sepsis is a life-threatening organ dysfunction caused by a dysregulated response to infection. It is responsible for approximately 50 million cases and 11 million deaths worldwide, accounting for about 20% of all global deaths. The challenge in accurately estimating sepsis and its associated mortality stems from varying definitions, diagnostic criteria, and coding practi...

Ethical Challenges With Pragmatic and Cluster RCTs In ICU Mon, 23 Sep 2024 Traditional explanatory randomised controlled trials (RCTs), often used for drug or device approval, assess interventions under ideal conditions but may not reflect real-world clinical practice, as they typically involve younger patients with fewer coexisting conditions. These trials also struggle to detect treatment effect differences among subgroups and rarely compare alternat...