Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest Mikael F. Vallentin, Asger Granfeldt, Thomas L. Klitgaard, et al N Engl J Med Published October 31, 2024 DOI: 10.1056/NEJMoa2407616 Abstract BACKGROUND Out-of-hospital cardiac arrest is a leading cause of death worldwide. Establishing vascular access is critical for administering guideline-recommended drugs during cardiopulmonary resuscitation. Both the intraosseous route and ...

COMMENTVolume 404, Issue 10464P1703-1705November 02, 2024Download Full Issue Haemodiafiltration improves survival in patients receiving dialysis Bruno Ranchin, Rukshana Shroff Lancet 2024; 404: 1703-1705 Chronic kidney disease is a global public health problem, affecting about 10% of the world's population,1 with increasing numbers requiring dialysis. Haemodialysis is the most commonly used dialysis modality, accounting for 89% of long-term dialysis ...

Sleep and Circadian Health of Critical Survivors In ICU Wed, 17 Jul 2024 A new study explores the long-term impact of ICU stays on sleep and circadian health among critical illness survivors, particularly those from the COVID-19 pandemic. Many patients experience persistent sleep disturbances and disrupted circadian rhythms after hospital discharge, attributed to factors like artificial light exposure, nighttime care interventions, and medical treatmen...

ORIGINAL ARTICLE A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest Keith Couper, Chen Ji, Charles D. Deakin, et al N Engl J Med Published October 31, 2024 DOI: 10.1056/NEJMoa2407780 Abstract BACKGROUND Out-of-hospital cardiac arrest is a leading cause of death worldwide. Establishing vascular access is critical for administering guideline-recommended drugs during cardiopulmonary resuscitation. Both the intraosseous route and the intra...

Research Association of holidays and the day of the week with suicide risk: multicountry, two stage, time series study Whanhee Lee, Cinoo Kang, Chaerin Park, et al BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-077262 (Published 23 October 2024)Cite this as: BMJ 2024;387:e077262 Abstract Objectives To assess the short term temporal variations in suicide risk related to the day of the week and national holidays in multiple countries. Design ...

ARTICLESVolume 404, Issue 10464P1742-1749 November 02, 2024 Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials Robin W M Vernooij, Carinna Hockham, Giovanni Strippoli, et al Lancet 2024; 404: 1742-1749 Summary Background High-dose haemodiafiltration has been shown, in a randomised clinical trial, to result in a 23% lower risk of mortality for patients with kidney failure wh...

Original Investigation  October 25, 2024 Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury: A Randomized Clinical Trial Abinet M. Aklilu, Steven Menez, Megan L. Baker, et al JAMA. Published online October 25, 2024. doi:10.1001/jama.2024.22718 Key Points Question  Among hospitalized patients with acute kidney injury, do diagnostic and therapeutic recommendat...

NIH Intervention to Reduce Opioid-Related Overdose Deaths In ICU Sun, 16 Jun 2024 A National Institutes of Health’s HEALing (Helping to End Addiction Long-Term) Communities Study evaluated a data-driven intervention aimed at reducing opioid-related overdose deaths by engaging communities to implement evidence-based practices, such as increasing naloxone distribution and enhancing access to medication for opioid use disorder. The findings are published ...

Editor's Note  October 19, 2024 The 2024 Revision to the Declaration of Helsinki: Modern Ethics for Medical Research Kirsten Bibbins-Domingo, Linda Brubaker, Greg Curfman JAMA. Published online October 19, 2024. doi:10.1001/jama.2024.22530 This JAMA issue focuses on important contemporary issues in ethics and medical research and is anchored by 2 Special Communications with their accompanying Viewpoints and Editorials. The first ...

JAMA Clinical Guidelines Synopsis  October 24, 2024 Prevention, Diagnosis, and Treatment of Acute Altitude Illness Mia Derstine, Elan Small, Andrew M. Davis JAMA. Published online October 24, 2024. doi:10.1001/jama.2024.19562 Guideline title Prevention, Diagnosis, and Treatment of Acute Altitude Illness Release date January 2024 Developer and funding source Wilderness Medical Society (WMS) ...