ORIGINAL ARTICLE Highly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans Shikha Garg, Katie Reinhart, Alexia Couture, et al N Engl J Med Published December 31, 2024 Abstract BACKGROUND Highly pathogenic avian influenza A(H5N1) viruses have caused widespread infections in dairy cows and poultry in the United States, with sporadic human cases. We describe characteristics of human A(H5N1) cases identified from March through October 2024 in the ...

Cardiogenic Shock: Definitions, Pathophysiology, Management Approaches  In ICU Mon, 18 Nov 2024 Cardiogenic shock (CS) is a life-threatening condition resulting from inadequate tissue perfusion due to reduced cardiac output. Despite advancements in cardiovascular care, its short-term mortality rate remains high, around 40-50%. CS can arise from diverse causes, including acute myocardial infarction (AMI), heart failure, post-surgical complications,...

ONLINE FIRST (FREE ACCESS) ARTIFICIAL INTELLIGENCE IN ICU TOPICAL COLLECTION Editorial Does artificial intelligence close gaps in clinical pharmacology in the ICU? Gijsen M. and De Waele J. J. What if we do, but what if we don’t? The opportunity cost of artificial intelligence hesitancy in the intensive care unit Spencer E-J, Economou-Zavlanos N. J. and van Genderen M. E. The role of artificial intelligence in life-sustaining treatment decisions: curr...

Research Letter  December 30, 2024 Antibody Response to Respiratory Syncytial Virus Vaccination in Immunocompromised Persons Andrew H. Karaba, Camille Hage, Isabella Sengsouk, et al JAMA. Published online December 30, 2024. doi:10.1001/jama.2024.25395 Respiratory syncytial virus (RSV) infection causes high morbidity in immunocompromised persons.1Novel prefusion F (preF)–containing RSV vaccines showed 13- to ...

ORIGINAL ARTICLE Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy Marianna Fontana, John L. Berk, Julian D. Gillmore, et al N Engl J Med 2025;392:33-44 DOI: 10.1056/NEJMoa2409134 Abstract BACKGROUND Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, a subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin. 转甲状腺素...

Impact of Emergency Department to ICU Time on Hospital Mortality In ICU Mon, 18 Nov 2024 What is the impact of prolonged emergency department (ED) length of stay (LOS), particularly ED-to-ICU time (from ED admission to ICU admission) and ED-boarding time (time between ICU admission decision and transfer), on hospital outcomes? Studies suggest prolonged ED-to-ICU times may increase ICU and hospital mortality, though findings are mixed.  Some EDs...

Research Letter  November 11, 2024 Online Retailer Nonadherence to Age Verification, Shipping, and Flavor Restrictions on E-Cigarettes Raquel M. Harati, Shannon E. Ellis, Nora Satybaldiyeva, et al JAMA. 2024;332(24):2113-2114. doi:10.1001/jama.2024.21597 To curtail youth access to vaping products, the 2020 Preventing Online Sales of E-Cigarettes to Children Act implemented a ban on the use of the United States Postal ...

Original Investigation  December 30, 2024 Pain Coping Skills Training for Patients Receiving Hemodialysis: The HOPE Consortium Randomized Clinical Trial Laura M. Dember, Jesse Y. Hsu, Rajnish Mehrotra, et al JAMA Intern Med. Published online December 30, 2024. doi:10.1001/jamainternmed.2024.7140 Key Points Question  Does pain coping skills training (PCST), a cognitive behavioral intervention, re...

Hypotension and Adverse Outcomes in Traumatic Brain Injury In ICU Mon, 18 Nov 2024 Traumatic brain injury (TBI) is a major cause of death and disability, with 60 million cases annually and 8.1 million years of disability worldwide. Hypotension, a common secondary injury in TBI, often results from blood loss or neurogenic causes like myocardial depression or brainstem herniation disrupting autonomic control. Hypotension significantly worsens outcomes, i...

Original Investigation  December 23, 2024 Variation in Emergency Department Physician Admitting Practices and Subsequent Mortality Stephen Coussens, Dan P. Ly JAMA Intern Med. Published online December 23, 2024. doi:10.1001/jamainternmed.2024.6925 Key Points Question  By how much does the propensity to admit patients vary across physicians within a given emergency department (ED), and do higher admission prope...