Original Investigation  August 28, 2024 Outcomes of Patients With Traumatic Brain Injury Transferred to Trauma Centers Sai Krishna Bhogadi, Collin Stewart, Hamidreza Hosseinpour, et al JAMA Surg. 2024;159(11):1282-1288. doi:10.1001/jamasurg.2024.3254 Key Points Question  What happens to patients with traumatic brain injury (TBI) who are transferred to higher-level trauma centers? Findings  In...

Leg Cycle Ergometry in Critically Ill Patients In ICU Mon, 14 Oct 2024 Physical rehabilitation interventions initiated in the ICU represent a proactive approach to reducing post-ICU impairments. While many clinical guidelines recommend starting rehabilitation during ICU care, there is no consensus on the optimal timing or specific type of intervention. The types of rehabilitation studied are diverse, leading to varying results across studies. Some rand...

Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study  Besu F Teshome,  Taehwan Park,  Joel Arackal,  et al Clinical Infectious Diseases, Volume 79, Issue 4, 15 October 2024, Pages 826–833, https://doi.org/10.1093/cid/ciae253 Abstract Background Whether antibiotic de-escalation reduces the risk of subsequent antibiotic resistance is...

Editorial  November 11, 2024 Intratracheal Budesonide Combined With Surfactant in Extremely Preterm Infants Erik A. Jensen JAMA. Published online November 11, 2024. doi:10.1001/jama.2024.19641 Infants born extremely premature (those with gestational ages of less than 28 weeks at delivery) are at risk of both acute and subsequent chronic respiratory insufficiency due in part to absent or inadequate production of pulmonary surfactant. More than...

Restrictive vs Liberal Transfusion Strategy in Acute Brain Injury In ICU Mon, 14 Oct 2024 The indications for red blood cell transfusions in critically ill patients without life-threatening bleeding are debated, particularly due to the balance between risks and benefits. While anaemia is linked to increased morbidity and mortality, blood transfusions can also lead to complications such as infection or lung injury. Several randomised clinical trials in ...

Original Investigation  November 11, 2024 Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants: The PLUSS Randomized Clinical Trial Brett J. Manley, C. Omar F. Kamlin, Susan M. Donath, et al JAMA. Published online November 11, 2024. doi:10.1001/jama.2024.17380 Key Points Question  What is the effect of intratracheal budesonide mixed with surfactant on survival free of...

Association Between Infectious Diseases Consultation and Mortality in Hospitalized Patients With Gram-negative Bloodstream Infection: A Retrospective Population-wide Cohort Study  Sean W X Ong,  Jin Luo,  Daniel J Fridman,  et al Clinical Infectious Diseases, Volume 79, Issue 4, 15 October 2024, Pages 855–863, https://doi.org/10.1093/cid/ciae282 Abstract Objectives Data supporting routine infectious diseases (ID) cons...

Editorial  September 25, 2024 Feasibility of Fever Prevention in Vascular Brain Injury Teresa May, Lori Shutter JAMA. 2024;332(18):1521-1522. doi:10.1001/jama.2024.16415 How to manage fever in the neurocritical care unit in patients with acute stroke was clearly a question in need of an answer. The association of fever burden with poor outcome for diverse conditions in the neurocritical care unit has been well described.1-3 However, distinguishing asso...

Original Investigation  September 25, 2024 Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial David M. Greer, Raimund Helbok, Neeraj Badjatia, et al JAMA. 2024;332(18):1525-1534. doi:10.1001/jama.2024.14745 Key Points Question  Is an automated surface temperature management device effective in prevention of fever in patients with acute vascular brain inju...

Telemedicine vs Emergency Department for Opioid Use Disorder In ICU Wed, 24 Jul 2024 A new study shows that telemedicine referrals for patients with opioid use disorder (OUD) are more effective than in-person emergency department visits for initiating and maintaining medication-assisted treatment (MAT) through outpatient clinics. The findings are published in the Journal of Substance Use and Addiction Treatment. This is the first study comparing tel...