Effect of PEEP on PVR in Patients With Acute Respiratory Distress Syndrome In ICU Mon, 21 Oct 2024 In mechanically ventilated patients with acute respiratory distress syndrome (ARDS), the use of positive end-expiratory pressure (PEEP) presents a therapeutic dilemma. PEEP can improve gas exchange and lung mechanics but may impair haemodynamics. Its effects primarily impact right ventricular (RV) preload and afterload, while left ventricular (LV) functio...

Research Letter  Infectious Diseases November 27, 2024 Testing and Masking Policies and Hospital-Onset Respiratory Viral Infections Theodore R. Pak, Tom Chen, Sanjat Kanjilal, et al JAMA Netw Open. 2024;7(11):e2448063. doi:10.1001/jamanetworkopen.2024.48063 Introduction Most hospitals have stopped testing all patients for SARS-CoV-2 upon admission and requiring masking. Ten hospitals in the Mass Genera...

Original Investigation  Infectious Diseases November 26, 2024 Use of Multiplex Molecular Panels to Diagnose Urinary Tract Infection in Older Adults Kelly M. Hatfield, Sarah Kabbani, Isaac See, et al JAMA Netw Open. 2024;7(11):e2446842. doi:10.1001/jamanetworkopen.2024.46842 Key Points Question  How frequently are multiplex molecular syndromic panels used to diagnose urinary tract infection (U...

ONLINE FIRST (FREE ACCESS) ICU TOOLBOX TOPICAL COLLECTION Editorial How I perform diaphragmatic ultrasound in the intensive care unitHermans G., Demoule A. and Heunks L. Invasive fungal infections in non-neutropenic patientsKreitmann L., Blot S. and Nseir S. My echo checklist in venoarterial ECMO patientsSaura O., Combes A. and Hekimian G. OPEN ACCESS ~ Editorial Managing blood glucose control in the intensive care unit Gunst J., Umpierrez G. E.&nb...

Current Controversies in Early Mobilisation in the ICU In ICU Tue, 1 Oct 2024 ICU Management & Practice, Volume 24 - Issue 4, 2024 This article will address current and controversial topics regarding early mobilisation and respiratory therapy in critically ill patients in the Intensive Care Unit (ICU). We will explore the implications, challenges, and potential benefits related to these interventions, highlighting the need for ongoing research ...

Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants NCD Risk Factor Collaboration (NCD-RisC) Lancet 2024; 404: 2077-2093 https://doi.org/10.1016/S0140-6736(24)02317-1 Summary Background Diabetes can be detected at the primary health-care level, and effective treatments lower the risk of complications. There are insufficient data on the coverage ...

Research Letter  November 20, 2024 The Quality of Evidence Supporting Clinical Practice Guidelines in General Surgery: A Meta-Analysis Ali B. Abbasi, Adrian Valderrama, Hannah C. Decker, et al JAMA Surg. Published online November 20, 2024. doi:10.1001/jamasurg.2024.4751 Clinical practice guidelines can help patients and physicians make decisions using the best available evidence. Unfortunately, the best avai...

Characterization of Gram-negative Bloodstream Infections in Hospitalized Australian Children and Their Clinical Outcomes  Sophie C H Wen,  Patrick N A Harris,  Brian Forde,  et al Clinical Infectious Diseases, Volume 79, Issue 3, 15 September 2024, Pages 734–743, https://doi.org/10.1093/cid/ciae341 Abstract Background Gram-negative bloodstream infections (GNBSIs) more commonly occur in children with comorbidities and ...

Research Letter  November 18, 2024 Caregiver-Reported Quality in Hospices Owned by Private Equity Firms and Publicly Traded Companies Alexander E. Soltoff, Mark Aaron Unruh, David G. Stevenson, et al JAMA. Published online November 18, 2024. doi:10.1001/jama.2024.20546 The US hospice industry has shifted from not-for-profit to for-profit ownership models,1,2producing concerns about care quality. For-profit h...

Early Mobilisation: Just a Fad?  In ICU Tue, 1 Oct 2024 ICU Management & Practice, Volume 24 - Issue 4, 2024 A review of recent evidence on early mobilisation and rehabilitation and what remains to be defined. Introduction Critical illnesses encompass a broad spectrum of pathologies that require support for different organs. This often leads to prolonged bed rest and secondary immobilisation, which ultimately fosters the development ...