Wastewater monitoring of human and avian influenza A viruses in Northern Ireland: a genomic surveillance study Andrew J Lee, Stephen Carson, Marina I Reyne, et al Lancet Microbe 2024; 5: 100933 Summary Background Influenza A viruses (IAVs) are significant pathogens of humans and other animals. Although endemic in humans and birds, novel IAV strains can emerge, jump species, and cause epidemics, like the latest variant of H5N1. Wastewater-based epi...

Research Letter  Pediatrics December 4, 2024 Accuracy in Measurement of Infant Formula Powder and Water by Caregivers With and Without a Crying Baby Present Richard R. Rosenkranz, Chris Acosta, Ana Gonzalez-Alvarez, et al JAMA Netw Open. 2024;7(12):e2447362. doi:10.1001/jamanetworkopen.2024.47362 Introduction Infant formula provides a safe, nutritious alternative to breastfeeding but caregivers may use...

Hospital Readmission After Surviving Sepsis In Sepsis Mon, 21 Oct 2024 Sepsis affects nearly 50 million people globally. Survivors face significant long-term issues like reduced quality of life and frequent hospital readmissions. Studies show that 21.4% of survivors are readmitted within 30 days and 39% by one year, with sepsis-related readmissions being costlier than those for other conditions like heart failure or myocardial infarction. Many readm...

Rapid multiplex PCR panel for pneumonia in hospitalised patients with suspected pneumonia in the USA: a single-centre, open-label, pragmatic, randomised controlled trial Abinash Virk, Angel P Strasburg, Kami D Kies, et al Lancet Microbe 2024; 5: 100928 https://doi.org/10.1016/S2666-5247(24)00170-8 Summary Background The clinical utility of rapid multiplex respiratory specimen PCR panels for pneumonia for patients with suspected pneumonia is undefined. We...

Original Investigation  October 7, 2024 Arm Position and Blood Pressure Readings: The ARMS Crossover Randomized Clinical Trial Hairong Liu, Di Zhao, Ahmed Sabit, et al JAMA Intern Med. 2024;184(12):1436-1442. doi:10.1001/jamainternmed.2024.5213 Key Points Question  What is the effect of commonly used arm positions on blood pressure (BP) measurements compared to the standard, recommended position? Findi...

Safety and efficacy of early versus delayed acetylsalicylic acid after surgery for spontaneous intracerebral haemorrhage in China (E-start): a prospective, multicentre, open-label, blinded-endpoint, randomised trial Qingyuan Liu, Shaohua Mo, Jun Wu, et al. Lancet Neurol 2024; 23: 1195-1204 https://doi.org/10.1016/S1474-4422(24)00424-1 Summary Background Patients with non-traumatic intracerebral haemorrhage have a substantial risk of major adverse cardiov...

Crowding of Emergency Departments: An Assessment of the NEDOCS In ICU Mon, 21 Oct 2024 Emergency department (ED) crowding is a global issue with a significant impact on patient outcomes, including increased medical errors, higher inpatient mortality, and poorer quality of care. It also leads to inefficiencies, such as longer waiting times and more patients leaving without being seen. The primary causes of crowding are staff shortages, sudden surges in ...

Research Cardiac output-guided haemodynamic therapy for patients undergoing major gastrointestinal surgery: OPTIMISE II randomised clinical trial OPTIMISE II Trial Group BMJ 2024; 387 doi: https://doi.org/10.1136/bmj-2024-080439 (Published 03 December 2024)Cite this as: BMJ 2024;387:e080439 Abstract Objectives To evaluate the clinical effectiveness and safety of a perioperative algorithm for cardiac output-guided haemodynamic therapy in patients underg...

ARTICLES Investigating the effect of enhanced cleaning and disinfection of shared medical equipment on health-care-associated infections in Australia (CLEEN): a stepped-wedge, cluster randomised, controlled trial Katrina Browne, Nicole M White, Philip L Russo, et al Lancet Infect Dis 2024 Online first August 13, 2024 https://doi.org/10.1016/S1473-3099(24)00399-2 Summary Background There is a paucity of high-quality evidence based on clinical endpoints...

Original Investigation  October 14, 2024 Acupuncture vs Sham Acupuncture for Chronic Sciatica From Herniated Disk: A Randomized Clinical Trial Jian-Feng Tu, Guang-Xia Shi, Shi-Yan Yan, et al JAMA Intern Med. 2024;184(12):1417-1424. doi:10.1001/jamainternmed.2024.5463 Key Points Question  Does acupuncture alleviate pain and improve function in patients with chronic sciatica from herniated disk? Findings...