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High dose coupled plasma filtration and adsorption in septic shock patients. Results of the COMPACT-2: a multicentre, adaptive, randomised clinical trial Elena Garbero, Sergio Livigni, Fiorenza Ferrari, et al Intensive Care Med Published: 03 October 2021 Abstract Purpose This study aimed at evaluating the efficacy and safety of high-dose (> 0.2 L/kg of treated plasma per day) coupled plasma filtration-adsorption (CPFA) in treating patients with septic sh...
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Why Intensivists Should Participate in Home Ventilation Teams A historical review of the birth of intensive care medicine and home mechanical ventilation; and an opinion piece on the merits of intensivists participating in home ventilation care teams. The world is currently reeling from the ravages of COVID-19. It is still too early to know how healthcare will be transformed as a result of this epidemic. For now, it appears that COVID-19 will leave behind large numb...
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Editorial September 3, 2021 Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink Kimberly G. Blumenthal, Neelam A. Phadke, David W. Bates JAMA. 2021;326(14):1375-1377. doi:10.1001/jama.2021.14808 Vaccines represent one of the greatest public health achievements of modern medicine. They must pass rigorous and predetermined efficacy and safety metrics prior to licensure. Additionally, postmarketing safety surveillance is essenti...
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ICU Management & Practice, Volume 19 - Issue 4, Winter 2019/2020 Future ICU Design: Return to High Visibility Future ICU designs must feature high visibility to ensure safety. The ability for critical care nurses, physician intensivists, and other caregivers to visualise their patients has always been a high priority as it plays a major role in patient and staff safety. Architects and designers have responded with configurations for intensive care units ...
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Original Investigation October 7, 2021 Association of Receipt of the Ad26.COV2.S COVID-19 Vaccine With Presumptive Guillain-Barré Syndrome, February-July 2021 Emily Jane Woo, Adamma Mba-Jonas, Rositsa B. Dimova, et al JAMA. Published online October 7, 2021. doi:10.1001/jama.2021.16496 Abstract Importance  As part of postauthorization safety surveillance, the US Food and Drug Administration (FDA) ha...
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Early vs Late Tracheostomy and Ventilator-Associated Pneumonia Surgically opening the windpipe, or trachea, within the first seven days of the start of mechanical ventilation decreases the time patients spend on ventilators, shortens their ICU stay and lowers their risk of ventilator-associated pneumonia, according to a new systematic review. "We analysed the existing medical literature to unravel a question that is very pertinent to adult critical care," said s...
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Original Investigation October 11, 2021 Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial Jean M. Connors, Maria M. Brooks, Frank C. Sciurba, et al JAMA. Published online October 11, 2021. doi:10.1001/jama.2021.17272 Abstract Importance  Acutely ill inpatients with COVID-19 typically receive antithrombotic therapy, although the ris...
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Original Investigation September 3, 2021 Surveillance for Adverse Events After COVID-19 mRNA Vaccination Nicola P. Klein, Ned Lewis, Kristin Goddard, et al JAMA. 2021;326(14):1390-1399. doi:10.1001/jama.2021.15072 Abstract Importance  Safety surveillance of vaccines against COVID-19 is critical to ensure safety, maintain trust, and inform policy. Objectives  To monitor 23 serious outcomes weekly, using comprehensive health record...
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RAPID Trial: Therapeutic Heparin vs Prophylactic Heparin in COVID-19 Patients A study was conducted to evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with COVID-19 admitted to the hospital. Heparin has anticoagulant properties, anti-inflammatory effects and potential antiviral effects and may also improve endothelial function. Early initiation of therapeutic heparin can decrease the thrombo-inflammato...
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Individualised versus conventional glucose control in critically-ill patients: the CONTROLING study—a randomized clinical trial Julien Bohé, Hassane Abidi, Vincent Brunot, et al Intensive Care Med Published: 29 September 2021 Abstract Purpose Hyperglycaemia is an adaptive response to stress commonly observed in critical illness. Its management remains debated in the intensive care unit (ICU). Individualising hyperglycaemia management, by targeting the patie...
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