Albumin Replacement Therapy in Septic Shock In Sepsis Wed, 4 Mar 2026 The Albumin Replacement Therapy in Septic Shock (ARISS) trial, published in JAMA Network Open was designed to determine whether albumin replacement improves survival in patients with septic shock. The study was conducted on behalf of the SepNet Critical Care Trials Group and ARISS investigators. Albumin is a natural colloid with physiological roles extending beyond maintenance of ...

Original Investigation  Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease: A Randomized Clinical Trial Himanshu Narang, Daizee Talukdar, Bipul Kumar, et al JAMA Intern Med Published Online: April 20, 2026 doi: 10.1001/jamainternmed.2026.0655 Key Points Question  Is fecal microbiota transplant (FMT) effective in achieving gut decolonization of...

Original Investigation  Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia: The FAST Randomized Clinical Trial Ritu Banerjee, Lauren Komarow, Yixuan Li, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2026.5487 Key Points Question  Does use of rapid antimicrobial susceptibility testing directly from blood culture bottles positive for gram-negative bacteria impro...

Integrating Circadian Medicine in Critical Care A structured roadmap for integrating circadian medicine into critical care was developed during a five-day international workshop held at the Lorentz Center in Leiden, The Netherlands. Circadian rhythms, self-sustained approximately 24-hour physiological cycles regulated by a central clock in the suprachiasmatic nucleus and peripheral clocks throughout the body, are fundamental to human health. In the ICU, however, th...

Original Investigation  Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults Timothy J. Savage, Anne M. Butler, Matthew P. Kronman, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2025.26902 Key Points Question  For acute sinusitis in adults younger than 65 years, is standard-dose amoxicillin-clavulanate associated with different risks of treatment failure and adver...

Original Investigation  Gastroenterology and Hepatology Computer-Assisted Colonoscopy in High–Adenoma Detection Rate Settings in a High-Risk Population: A Randomized Clinical Trial Wen-Feng Hsu, Chen-Ya Kuo, Hsu-Heng Yen, et al JAMA Netw Open 2026;9;(4):e264881. doi:10.1001/jamanetworkopen.2026.4881 Key Points Question  Does the use of computer-aided detection (CAD) during colonoscopy improve adenoma dete...

EDITORIAL Selective Digestive Decontamination — Finding the Way Forward Michael Klompas N Engl J Med 2026;394:1543-1545 DOI: 10.1056/NEJMe2602823 In critical care, selective digestive decontamination (SDD) is the elephant in the room. Cluster-randomized trials, individually randomized trials, and meta-analyses have shown that the use of SDD is associated with a decreased risk of ventilator-associated pneumonia, of hospital-onset bacteremia, and in some stud...

NIVPredict: AI Tool for Early Prediction of NIV Outcome in Acute Respiratory Failure In ICU Tue, 17 Feb 2026 Patients with acute respiratory failure (ARF) who fail non-invasive ventilation (NIV) and subsequently require intubation face a significantly elevated risk of death. No formal clinical guidelines currently exist to assist clinicians in identifying which patients are most likely to fail NIV in a timely manner. Existing clinical scoring tools, in...

Original Investigation  Surgery β-Lactam vs Non–β-Lactam Prophylaxis in Elective Colorectal Surgery Curtis D. Collins, Eric Hartsfield, Robert K. Cleary, et al JAMA Netw Open 2026;9;(4):e266708. doi:10.1001/jamanetworkopen.2026.6708 Key Points Question  Are surgical prophylaxis regimens containing β-lactam antibiotics associated with lower surgical site infections (SSIs) compared with non–β-lactam alternative regimens in patients undergoin...

Original Investigation  Health Informatics Large Language Model Performance and Clinical Reasoning Tasks Arya S. Rao, Kaiz P. Esmail, Richard S. Lee, et al JAMA Netw Open 2026;9;(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 Key Points Question  Can off-the-shelf large language models (LLMs) demonstrate reliable performance across the clinical workflow? Findings  In this cross-sectional study of 21 frontier LLMs tested on ...