Original Investigation  Obstetrics and Gynecology April 9, 2025 Pregnancy-Related Deaths in the US, 2018-2022 Yingxi Chen, Meredith S. Shiels, Tarsicio Uribe-Leitz, et al JAMA Netw Open. 2025;8(4):e254325. doi:10.1001/jamanetworkopen.2025.4325 Key Points Question  What is the pattern of pregnancy-related deaths in the US? Findings  In this cross-sectional analysis of 6283 pregnan...

Impact of Postoperative Sepsis on Dementia In Sepsis Mon, 10 Feb 2025 Dementia is a progressive neurodegenerative disease with growing public health and economic implications. In 2019, 57.4 million people had dementia worldwide, a number projected to reach 152.8 million by 2050. The global financial burden is substantial, estimated at $1.31 trillion annually. As dementia prevalence rises, increased healthcare resources and preventive strategies will be...

Editorial  March 31, 2025 Mitigating the Impact of Retracted Studies in the Medical Literature Cary P. Gross, Annette Flanagin, Eli N. Perencevich, et al JAMA Intern Med. Published online March 31, 2025. doi:10.1001/jamainternmed.2025.0251 Medical publishing, and the scientific research ecosystem in general, face substantial challenges. Some are external, ranging from a relative decrease in research funding, to i...

Original Investigation  Pediatrics April 9, 2025 Multimodal Monitoring of Hemodynamics in Neonates With Extremely Low Gestational Age: A Randomized Clinical Trial Renjini Lalitha, Eyad Bitar, Matthew Hicks, et al JAMA Netw Open. 2025;8(4):e254101. doi:10.1001/jamanetworkopen.2025.4101 Key Points Question  Does multimodal hemodynamic assessment during the transitional period (first 72 hours of...

Extracorporeal Blood Purification in Critically Ill Paediatric Patients In ICU Mon, 10 Feb 2025 Extracorporeal blood purification therapies (EBPTs) use extracorporeal circuits to remove or modulate circulating substances for organ support and detoxification. These therapies include renal replacement therapy, ultrafiltration, haemoadsorption, and plasma therapies. Recent advances in technology have expanded EBPTs from single-organ to multiple-organ supp...

Original Investigation  Health Informatics June 9, 2020 Association of Electronic Health Record Use With Physician Fatigue and Efficiency Saif Khairat, Cameron Coleman, Paige Ottmar, et al JAMA Netw Open. 2020;3(6):e207385. doi:10.1001/jamanetworkopen.2020.7385 Key Points Question  What is the association between electronic health record use and physician fatigue and efficiency? Findings&n...

Research Letter  Nephrology March 5, 2025 Predicting Contrast-Associated Acute Kidney Injury Yunlin Feng, Min Jun, Amanda Y. Wang, et al JAMA Netw Open. 2025;8(3):e250107. doi:10.1001/jamanetworkopen.2025.0107 Introduction Contrast-associated acute kidney injury (CA-AKI), defined as AKI after exposure to a diagnostic or therapeutic radio-contrast agent,1 is an important clinical problem.2 CA-...

Editorial  March 30, 2025 Risk of Running—A Contemporary Look at Cardiac Arrest in Long-Distance Races Nimesh S. Patel, Mark S. Link JAMA. Published online March 30, 2025. doi:10.1001/jama.2025.3646 Millions of people participate in long-distance running, particularly marathons and half-marathons, annually.1While the health benefits of regular exercise are well established,2 long-distance running can cause significant cardiovascular stre...

Liberal vs Restrictive Transfusion Strategies in Subarachnoid Haemorrhage In ICU Mon, 10 Feb 2025 Spontaneous aneurysmal subarachnoid haemorrhage (SAH) is a serious cerebrovascular event contributing significantly to morbidity and mortality. It is often associated with anaemia, which can worsen brain injury through cerebral hypoxia, particularly when haemoglobin (Hb) levels drop below 5 g/dL.  In healthy brains, anaemia is compensated by increa...

SPECIAL ARTICLE Association between Wealth and Mortality in the United States and Europe Sara Machado, Ilias Kyriopoulos, John Orav, et al N Engl J Med 2025;392:1310-1319 Abstract BACKGROUND Amid growing wealth disparity, we have little information on how health among older Americans compares with that among older Europeans across the distribution of wealth. METHODS We performed a longitudinal, retrospective cohor...