Epidemiology and Outcomes of Antibiotic De-escalation in Patients With Suspected Sepsis in US Hospitals Kai Qian Kam, Tom Chen, Sameer S Kadri, et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 108–117, https://doi.org/10.1093/cid/ciae591 Abstract Background Little is known about the frequency, hospital-level variation, predictors, and outcomes of antibiotic de-escalation in suspected sepsis. Methods We...

Comment Effect of normobaric hyperoxia in ischaemic stroke Diederik W J Dippel, Paula M Janssen Lancet 2025; 405: 442-443 DOI: https://doi.org/10.1016/S0140-6736(25)00153-9 In ischaemic stroke, discontinuation of local arterial blood supply to the brain leads to neurological deficits. The assumption that increased delivery of oxygen in patients with acute ischaemic stroke might lead to amelioration of neurological deficit is interesting, but almost all larg...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial Tobias Arleth, Josefine Baekgaard, Volkert Siersma, et al JAMA. 2025;333(6):479-489. doi:10.1001/jama.2024.25786 Key Points Question  Does an early, 8-hour restrictive oxygen strategy compared with a liberal oxygen stra...

Management of Pain and Sedation In ICU Tue, 7 Jan 2025 The evolution of critical care medicine has greatly advanced understanding and practices in pain and sedation management. Historically, deep sedation was believed to aid recovery, but it is now recognised to delay recovery and increase harm. Current strategies emphasise carefully titrated analgesia and sedation to ensure patient comfort, safety, and procedural facilitation, while minimising risks l...

Original Investigation  February 10, 2025 Evaluation of a Clinical Decision Support System for Imaging Requests: A Cluster Randomized Clinical Trial Stijntje W. Dijk, Claudia Wollny, Joerg Barkhausen, et al JAMA. Published online February 10, 2025. doi:10.1001/jama.2024.27853 Key Points Question  How does a clinical decision support system (the European Society of Radiology iGuide) affect the ap...

Articles Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial Weili Li, Jing Lan, Ming Wei, et al Lancet 2025; 405: 486-497 DOI: https://doi.org/10.1016/S0140-6736(24)02809-5 Summary Background Endovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment,...

Comment On the quantification of military violence in Gaza James Smith, Duha Shellah, Zoé Samudzi Lancet 2025; 405: 440-442 DOI: https://doi.org/10.1016/S0140-6736(25)00138-2 Against a history of protracted occupation,1 an unprecedented escalation in Israeli State violence occurred throughout Palestine in the wake of violent attacks in Israel on Oct 7, 2023.2 Concerning violence throughout Gaza, mortality statistics subsequently reported by the Pa...

Extracorporeal Blood Purification Therapies in Sepsis In Sepsis Tue, 7 Jan 2025 Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Sepsis involves both pro-inflammatory and anti-inflammatory processes, which can occur early in the disease and explain the severe clinical outcomes such as septic shock and premature death. However, each patient follows a unique immune response trajecto...

ARTICLESVolume 405, Issue 10477P478-485February 08, 2025Download Full Issue Life expectancy losses in the Gaza Strip during the period October, 2023, to September, 2024 Michel Guillot, Mohammed Draidi, Valeria Cetorelli, et al Lancet 2025; 405: 478-485 DOI: 10.1016/S0140-6736(24)02810-1 Summary Background In the context of the ongoing war in the Gaza Strip, the Gaza Health Ministry (GHM) has reported 45 936 fatalities and more than 10 000 individ...

ARTICLESVolume 405, Issue 10477 P469-477 February 08, 2025 Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis Zeina Jamaluddine, Hanan Abukmail, Sarah Aly, et al Lancet 2025; 405: 569-477 DOI: 10.1016/S0140-6736(24)02678-3 Summary Background Accurate mortality estimates help quantify and memorialise the impact of war. We used multiple data sources to estimate deaths due to traumatic injury in ...