Original Investigation  Less Is More April 10, 2025 Improving Empiric Antibiotic Selection for Patients Hospitalized With Skin and Soft Tissue Infection: The INSPIRE 3 Skin and Soft Tissue Randomized Clinical Trial Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA Intern Med. Published online April 10, 2025. doi:10.1001/jamainternmed.2025.0887 Key Points Question  Can computerized pr...

Invited Commentary  Pediatrics April 11, 2025 Vasoactive Selection for Pediatric Septic Shock—Where to Begin? Scott L. Weiss JAMA Netw Open. 2025;8(4):e254726. doi:10.1001/jamanetworkopen.2025.4726 Vasoactive medications are commonly used to reverse cardiovascular dysfunction and optimize tissue perfusion in children with fluid-refractory or fluid-averse septic shock. The 2020 Surviving Sepsis Campaign International Guidelines for the Mana...

Variability in Interprofessional ICU Staffing In ICU Tue, 4 Mar 2025 ICU staffing varies widely due to factors like physician work-hour limitations, increased use of advanced practice providers (NPs and PAs), telemedicine, and shortages of healthcare workers, including nurses and ICU physicians. There is limited and low-quality data to guide staffing decisions, with most research focusing on individual roles rather than the interprofessional teams that...

Original Investigation  Pediatrics April 11, 2025 Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock Matthew A. Eisenberg, Nathan Georgette, Alexandra H. Baker, et al JAMA Netw Open. 2025;8(4):e254720. doi:10.1001/jamanetworkopen.2025.4720 Key Points Question  Is there an association between the first vasoactive agent administered and outcomes in children with se...

Research Letter  April 9, 2025 Concordance of 30-Day Mortality and In-Hospital Mortality or Hospice Discharge After Sepsis Hallie C. Prescott, Megan Heath, Namita Jayaprakash, et al JAMA. Published online April 9, 2025. doi:10.1001/jama.2025.2526 Sepsis contributes to 1.7 million adult hospitalizations and 350 000 deaths annually in the United States.1To encourage improvements in sepsis management and outcom...

Invited Commentary  Health Informatics April 7, 2025 Are All Cytokine Storms Born Equal? Andre C. Kalil, Anum Abbas, Sias J. Scherger JAMA Netw Open. 2025;8(4):e253466. doi:10.1001/jamanetworkopen.2025.3466 One of the most difficult medical challenges we have faced for decades is regarding the human host response to infectious and noninfectious insults. We are still lacking understanding on what constitutes adaptive and maladaptive host re...

Original Investigation  Health Informatics April 7, 2025 Cytokine Storms in COVID-19, Hemophagocytic Lymphohistiocytosis, and CAR-T Therapy James P. Long, Rishab Prakash, Paul Edelkamp Jr, et al JAMA Netw Open. 2025;8(4):e253455. doi:10.1001/jamanetworkopen.2025.3455 Key Points Question  How do clinical patterns and outcomes of cytokine storm (CS) vary among etiologies of cytokine releas...

The Future of Extracorporeal Care In ICU Tue, 4 Mar 2025 The incidence of long COVID is estimated to be between 6% and 40%. This highlights the need for ongoing care beyond initial survival. However, healthcare often focuses on survival as a binary outcome rather than considering the long-term recovery process, which can range from full recovery to ongoing dependence on institutional care and rehabilitation. There is an increasing need to address the c...

Original Investigation  Critical Care Medicine April 8, 2025 Post–Intensive Care Syndrome and Caregiver Burden: A Post Hoc Analysis of a Randomized Clinical Trial Soojung Ahn, Marianna LaNoue, Han Su, et al JAMA Netw Open. 2025;8(4):e253443. doi:10.1001/jamanetworkopen.2025.3443 Key Points Question  What is the long-term association between patient post–intensive care syndrome (PICS) and care...

Invited Commentary  Cardiology April 2, 2025 What’s Missing From Value-Based Care—Accounting for the Costs and Benefits of Quality Improvement Donald E. Casey Jr JAMA Netw Open. 2025;8(4):e252510. doi:10.1001/jamanetworkopen.2025.2510 Current estimated direct and indirect economic cost of cardiovascular diseases from 2019 to 2020 was $422.3 billion with coronary heart disease (CHD) accounting for more than 40% of deaths attributable to dis...