Original Investigation  Lung Transplant for Refractory Lung-Limited Stage IV Non–Small Cell Lung Cancer Ankit Bharat, Chitaru Kurihara, Liam IL-Young Chung, et al JAMA Published Online: July 8, 2026 doi: 10.1001/jama.2026.8717 Key Points Question  Among selected adults with medically refractory, lung-limited, stage IV non–small cell lung cancer (NSCLC), what are the outcomes with lung transplant and how does early overall survival compare ...

Editorial  A Multinational Trial of Rapid Antimicrobial Susceptibility Testing: Is FASTer Better? Arjun Srinivasan JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2026.5504 Selecting the right antibiotic to treat an infection is the cornerstone of effective antibacterial therapy and lifesaving in severe infections.1 The growing epidemic of antimicrobial resistance is making decisions about empiric treatment increasingly difficult and elevating ...

Deep Learning Models for ICU Readmission Prediction In ICU Tue, 21 Oct 2025 The decision to discharge patients from the ICU is complex, as premature discharge increases the risk of readmission and mortality, while delayed discharge raises healthcare costs. ICU readmission is associated with over twice the mortality risk, longer hospital stays, greater morbidity, and higher resource use. Several predictive models, such as SWIFT, APACHE II and III, and S...

Original Investigation  Infectious Diseases Pharmacokinetics of Dalbavancin in Complicated Staphylococcus aureus Bacteremia: A Secondary Analysis of the DOTS Randomized Clinical Trial Thomas P. Lodise, Nicholas A. Turner, Toshimitsu Hamasaki, et al JAMA Netw Open 2026;9;(4):e2611652. doi:10.1001/jamanetworkopen.2026.11652 Key Points Question  What are the pharmacokinetics of a 2-dose dalbavancin regimen used for consolidation therapy in co...

Original Investigation  Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial Nicholas A. Turner, Toshimitsu Hamasaki, Sarah B. Doernberg, et al JAMA 2025;334;(10):866-877. doi:10.1001/jama.2025.12543 Key Points Question  Is dalbavancin a superior treatment option for complicated Staphylococcus aureus bacteremia compared with standard care? F...

Invited Commentary  Health Informatics Limitations of Large Language Models in Clinical Diagnostic Reasoning Mickael Tordjman, Xueyan Mei JAMA Netw Open 2026;9;(4):e264014. doi:10.1001/jamanetworkopen.2026.4014 Large language models (LLMs) have rapidly gained an important role in multiple fields, including medicine. These widely available tools can enhance patient understanding, improve physician productivity, and provide encyclopedic knowledge on seve...

Pulmonary Haemodynamic Trajectories in ECMO-Supported ARDS In ICU Wed, 4 Mar 2026 A recent study investigated the prevalence, determinants, and prognostic implications of pulmonary hypertension (PH) in patients with acute respiratory distress syndrome (ARDS) supported with veno-venous extracorporeal membrane oxygenation (V-V ECMO). PH, defined as a mean pulmonary artery pressure (mPAP) greater than 20 mmHg, is a recognised complication of ARDS and cont...

Research Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis Chanyan Huang, Xu Zhao, Siyu Geng, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2025-089001 (Published 09 April 2026)Cite this as: BMJ 2026;393:e089001 Abstract Objective To evaluate the effectiveness of perioperative non-drug interventions in reducing postoperative pulmonary complications (P...

WHO guidelines for the clinical management of filovirus disease: Executive summary Key recommendations Systematic patient monitoring should be established for patients with suspected or confirmed filovirus disease, using structured and documented clinical assessment at regular intervals, with frequency adapted to patient condition (Good practice statement). WHO recommends that for patients with suspected or confirmed filovirus disease, systematic laboratory moni...

Invited Commentary  The Mechanics of Improving Compliance Meghan C. O’Leary, Jessica R. Schumacher, Gita N. Mody JAMA Surg Published Online: April 15, 2026 doi: 10.1001/jamasurg.2026.0897 We were pleased to read the report by Chan et al1 about an American College of Surgeons national quality improvement (QI) collaborative. The Lung Nodal, Operative, Dissection, Evaluation, and Staging (NODES) initiative involved a collection of multilevel interventions...