Original Investigation  Cardiology Sivelestat and Incidence of Acute Respiratory Distress Syndrome After Cardiovascular Surgery: A Randomized Clinical Trial Tuo Pan, Can Xu, Ya-Peng Wang, et al JAMA Netw Open 2026;9;(3):e260390. doi:10.1001/jamanetworkopen.2026.0390 Key Points Question  Does postoperative administration of the neutrophil elastase inhibitor sivelestat reduce the incidence of acute respiratory dis...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Understanding lung physiology through ventilator screenCarteaux, G., Spinelli, E. & Jaber, S. LATEST ARTICLES OriginalPlasminogen supplementation reverses fibrinolytic insufficiency in sepsis-induced disseminated intravascular coagulation: a pilot studyTschirhart, M., Curtiaud, A., Abou Rjeily, R. et al. OPEN ACCESS ~ Original Association between ABCDE bundle ...

ANDROMEDA-SHOCK 1 to ANDROMEDA-SHOCK 2: Capillary Refill Time & Personalised Haemodynamic Management In ICU Wed, 3 Dec 2025 ICU Management & Practice, Volume 25 - Issue 5, 2025 From ANDROMEDA-SHOCK 1 to ANDROMEDA-SHOCK 2, capillary refill time evolved from a bedside sign to a personalised, physiology-based resuscitation target with direct implications for clinical practice and ICU organisation. Introduction The evolution of haemodynamic re...

Original Investigation  Emergency Medicine Incidence of Out-of-Hospital Cardiac Arrest on a Postholiday Weekday Min-Su Cha, Myoung-Je Song, Jong-Sun Kim JAMA Netw Open 2026;9;(3):e260832. doi:10.1001/jamanetworkopen.2026.0832 Key Points Question  Is a postholiday weekday associated with a higher out-of-hospital cardiac arrest incidence vs baseline weekdays in South Korea? Findings  In this cohort ...

Rethinking Delirium in Critical Care In ICU Tue, 14 Oct 2025 ICU Management & Practice, Volume 25 - Issue 4, 2025 Delirium is a common but under-recognised ICU complication with short and long term cognitive, psychological, and functional consequences. It urges for a cultural change in critical care using routine screening, multidisciplinary prevention, and patient and family centred interventions to prioritise mental recovery alongside physical sur...

Articles Blood biomarkers for the prediction of outcome after cardiac arrest: an international prospective observational study within the Targeted Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial Marion Moseby-Knappe, Helena Levin, Susann Ullén, et al Lancet Respir Med Available online 11 December 2025 https://doi.org/10.1016/S2213-2600(25)00363-7 Summary Background Prognostication of recovery in patients who are uncon...

Respiratory Mechanics and Effort During SBTs to Predict Extubation Failure In ICU Thu, 11 Dec 2025 A study recently published in the American Journal of Respiratory and Critical Care Medicine investigated whether noninvasive monitoring of respiratory mechanics during spontaneous breathing trials (SBTs) could predict extubation failure in high-risk patients. The research was conducted across five general intensive care units in Italy between September 2022 ...

Human-Centred AI in Critical Care  In ICU Thu, 11 Dec 2025 A recent review advocates for a fundamental shift in how artificial intelligence is integrated into intensive care units, moving away from a narrow focus on model development towards comprehensive human-centred AI system design. The discussion is based on the World Health Organization’s 2021 ethical framework, which establishes six core principles for AI in healthcare: protecting human aut...

Articles Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial Miriam M Treggiari, Emily S Sharp, Tetsu Ohnuma, et al Lancet Respir Med 2026; 14: 141-150 https://doi.org/10.1016/S2213-2600(25)00294-2 Summary Background Endotracheal tubes with subglottic ports and a polyurethane cuff are recommended for reducing microaspi...

ImmunoSep: Precision Immunotherapy to Improve Sepsis Outcomes  In Sepsis Thu, 11 Dec 2025 Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Many immunotherapy trials have failed because sepsis presents with highly variable immune states, ranging from excessive inflammation to profound immunosuppression. A precision-medicine approach, guided by rapid biomarker-based immune profiling, may therefore be need...