Original Investigation  Infectious Diseases March 14, 2025 Probiotics and Fever Duration in Children With Upper Respiratory Tract Infections: A Randomized Clinical Trial Silvia Bettocchi, Anna Comotti, Marina Elli, et al JAMA Netw Open. 2025;8(3):e250669. doi:10.1001/jamanetworkopen.2025.0669 Key Points Question  Does a probiotic mixture containing Bifidobacterium breve M-16V, ...

SUNRRISE: Negative Pressure Dressings to Prevent SSI After Emergency Laparotomy In ICU Tue, 4 Feb 2025 Surgical site infections (SSI) occur in up to 40% of patients after emergency laparotomy, leading to delayed healing, wound dehiscence, hernia risk, longer hospital stays, and higher readmission rates. These infections are a significant burden on patients, hospitals, and healthcare systems. Emergency laparotomies are critical for treating conditions l...

Original Investigation Emergency Medicine March 14, 2025 Therapy Dogs for Anxiety in Children in the Emergency Department: A Randomized Clinical Trial Heather P. Kelker, Huma K. Siddiqui, Alan M. Beck, et al JAMA Netw Open. 2025;8(3):e250636. doi:10.1001/jamanetworkopen.2025.0636 Key Points Question  Can adjunctive use of therapy dogs in child-life therapy reduce both child-reported anxiety and pa...

Original Investigation  January 27, 2025 Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial SUNRRISE Trial Study Group JAMA. 2025;333(10):853-863. doi:10.1001/jama.2024.24764 Key Points Question  Among patients undergoing emergency laparotomy, is there a difference in surgical site infection (SSI) rates when the wound is treated with incisional negative pre...

Invited Commentary  Pediatrics March 6, 2025 Changes in Respiratory Viral Testing Before and After the COVID-19 Pandemic Todd W. Lyons, Caroline G. Kahane JAMA Netw Open. 2025;8(3):e250168. doi:10.1001/jamanetworkopen.2025.0168 As an intern during the winter of 2008, I presented a full service of children admitted overnight with bronchiolitis. It had been 2 years since the initial publication of the American Academy of Pediatrics’ “Diagno...

Original Investigation  March 10, 2025 Awake Prone Positioning in Adults With COVID-19: An Individual Participant Data Meta-Analysis Jian Luo, Ivan Pavlov, Elsa Tavernier, et al JAMA Intern Med. Published online March 10, 2025. doi:10.1001/jamainternmed.2025.0011 Key Points Question  Is awake prone positioning (APP) associated with better odds of survival without intubation compared with supine ...

AI-Powered Prediction Model to Enhance Blood Transfusion Decision-Making  In ICU Fri, 24 Jan 2025 Researchers at Emory University have developed an advanced artificial intelligence (AI) model that accurately predicts the need for blood transfusions in non-traumatic ICU patients. Published in Health Data Science, the study tackles longstanding challenges in forecasting transfusion requirements across diverse patient populations with varying me...

ARTICLESVolume 405, Issue 10481P839-849March 08, 2025Download Full Issue Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China Anwen Xiong, Lei Wang, Jianhua Chen, et al Lancet 2025; 405: 839-849 Summary Background Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outc...

Invited Commentary  March 5, 2025 Indocyanine Green Fluorescence for Colectomy—Better Than the Naked Eye? Matthew Z. Wilson, David B. Stewart JAMA Surg. Published online March 5, 2025. doi:10.1001/jamasurg.2025.0015 Anastomotic leaks (ALs) are often devastating complications that frequently require unplanned reoperation, creation of a stoma that may be permanent, and months of management until the potential restoration of gut continuity.1&nbs...

ARTICLESVolume 405, Issue 10481P813-838March 08, 2025Open AccessDownload Full Issue Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021 GBD 2021 Adult BMI Collaborators Lancet 2025; 405: 813-838 Summary Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing...