Original Investigation  Infectious Diseases April 24, 2025 Dwell Time and Risk of Bloodstream Infection With Peripheral Intravenous Catheters Marie-Céline Zanella, Gaud Catho, Holly Jackson, et al JAMA Netw Open. 2025;8(4):e257202. doi:10.1001/jamanetworkopen.2025.7202 Key Points Question  What is the association of dwell time with the risk of bloodstream infections with peripheral intravenou...

Original Investigation  Emergency Medicine April 25, 2025 Health Care Resource Utilization for Patients With Suspected Myocardial Infarction: A Secondary Analysis of the RACE-IT Randomized Clinical Trial Joseph Miller, Bernard Cook, Satheesh Gunaga, et al JAMA Netw Open. 2025;8(4):e256930. doi:10.1001/jamanetworkopen.2025.6930 Key Points Question  Does implementing a 0-hour and 1-hour (hereaf...

SESAR Trial: Inhaled Sedation in Acute Respiratory Distress Syndrome In ICU Tue, 18 Mar 2025 Acute respiratory distress syndrome (ARDS) is common in ICU patients and has high mortality rates (35%-46%). Mechanical ventilation is essential for ARDS management and often requires sedation, though the optimal sedative choice remains unclear. Guidelines suggest light sedation with nonbenzodiazepine sedatives like propofol or dexmedetomidine, but specific rec...

Original Investigation  April 24, 2025 Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US Mathew V. Kiang, Kate M. Bubar, Yvonne Maldonado, et al JAMA. Published online April 24, 2025. doi:10.1001/jama.2025.6495 Key Points Question  How will declining childhood vaccination rates affect the risk of outbreaks and reemergence of previously eliminate...

Causes of and risk factors for postpartum haemorrhage: a systematic review and meta-analysis Idnan Yunas, Md Asiful Islam, Kulandaipalayam N Sindhu, et al Lancet 2025; 405: 1468-1480 Summary Background An understanding of the causes of postpartum haemorrhage is needed to provide appropriate treatment and services. Knowledge of the risk factors for postpartum haemorrhage can help address modifiable risk factors. We did a systematic review and meta-analysis t...

EDITORIAL Baloxavir Treatment to Reduce Influenza Virus Transmission Timothy M. Uyeki, Vivien G. Dugan, Demetre C. Daskalakis N Engl J Med 2025;392:1652-1654 Antiviral treatment of influenza is recommended as soon as possible for hospitalized patients and for outpatients who are at increased risk for influenza-related complications.1,2 The Food and Drug Administration–approved oral antiviral agent oseltamivir is the most widely used antiviral medication f...

Original Investigation  Ethics April 23, 2025 Incidence and Prevalence of Reported Euthanasia Cases in Belgium, 2002 to 2023 Jacques Wels, Natasia Hamarat JAMA Netw Open. 2025;8(4):e256841. doi:10.1001/jamanetworkopen.2025.6841 Key Points Question  What factors are associated with patterns in euthanasia incidence and prevalence in Belgium? Findings  In this cross-sectional analysis of all 33 58...

Anaesthesia Workforce Shortage: Reasons and Potential Solutions In ICU Mon, 10 Mar 2025 ICU Management & Practice, Volume 25 - Issue 1, 2025 PRINT OPTIMISED SCREEN OPTIMISED The shortage of anaesthetists poses significant challenges in healthcare. Potential short- and long-term solutions, oriented to ensure adequate patient care and safety are the topic of this article. It is becoming increasingly challenging for the directors of anaes...

ORIGINAL ARTICLE Global Effect of Cardiovascular Risk Factors on Lifetime Estimates The Global Cardiovascular Risk Consortium N Engl J Med Published March 30, 2025 DOI: 10.1056/NEJMoa2415879 Abstract BACKGROUND Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. ...

Editorial  March 3, 2025 Protein S Genomics and Proteomics Refine Thrombosis Risk Margaret V. Ragni JAMA. 2025;333(16):1401-1402. doi:10.1001/jama.2025.1883 Protein S is a vitamin K–dependent protein named after Seattle, where it was isolated and characterized. Subsequently recognized as a multifunctional enzyme that plays a critical role in the regulation of coagulation, protein S limits excessive clot formation through its action on clot initiation a...