Original Investigation  Global Burden of Disease Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021 GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators JAMA Neurol 2025;82;(8):765-787. doi:10.1001/jamaneurol.2025.1522 Key Points Question  What is the global burden of nontraumatic subarachnoid hemorrhage (SAH)? Findings  Results of this cross-...

#EA25: Anaesthesia in 2050: How Emerging Technologies Will Transform Practice In ICU Sun, 25 May 2025 Each year, Euroanaesthesia opens with the prestigious Sir Robert Macintosh Lecture to honour people who have made extraordinary contributions to the fields of anaesthesiology and intensive care. In light of the rapid and transformative rise of Artificial Intelligence (AI) in healthcare, this year’s lecture explored the profound implications of emerg...

Editorial  New Pathways to Treat Staphylococcus aureus Bacteremia: Connecting the DOTS Erin K. McCreary, Preeti N. Malani JAMA Published Online: August 13, 2025 doi: 10.1001/jama.2025.13717 Staphylococcus aureus bacteremia is a leading cause of infection-related death worldwide.1 Roughly 30% of patients who develop S aureus bacteremia will die within a year of index culture, yet relatively few randomized clinical trials have evaluat...

Original Investigation  Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis: A Systematic Review and Bayesian Meta-Analysis Connor Prosty, Dean Noutsios, Laurie-Rose Dubé, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3832 Key Points Question  Are shorter durations (including 0 days) noninferior to longer durations of antib...

Original Investigation  Global Scaling of a Surgical Infection Prevention Program to 5 Low-Resource Countries Writing Group for the Clean Cut Investigators Group JAMA Surg Published Online: August 13, 2025 doi: 10.1001/jamasurg.2025.2790 Key Points Question  Can a previously validated quality improvement program shown to be effective in preventing surgical infections in Ethiopia be scaled to other low-income settings through...

Steroids to Battle the Perfect Storm? Role of Corticosteroid Treatment in Sepsis Complicated by ARDS In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Both sepsis and Acute Respiratory Distress Syndrome (ARDS) are major determinants of morbidity and mortality in the ICU, and sepsis is often complicated by ARDS. We discuss the role of corticosteroids in these patients. Introduction Acute respiratory distress synd...

Research Letter  Emergency Medicine Electric Fan Use With Dehydration in Extreme Heat and Humidity: A Randomized Crossover Trial Connor Graham, Lily Hospers, Ollie Jay JAMA Netw Open 2025;8;(8):e2526701. doi:10.1001/jamanetworkopen.2025.26701 Introduction Heat extremes have devastating impacts on human health. More than 60 000 heat-related deaths occurred in the 2022 European summer,1 while record-breaking temperat...

Interpreting Elevated Lactate Levels in Shock States In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Elevated lactate levels indicate higher morbidity and mortality but require careful interpretation. In the presence of tissue hypoperfusion, they should prompt urgent haemodynamic optimisation. Without such signs, they warrant reassessing diagnosis and treatment. Serial lactate levels guide overall management but hav...

Original Investigation  Dalbavancin for Treatment of Staphylococcus aureus Bacteremia: The DOTS Randomized Clinical Trial Nicholas A. Turner, Toshimitsu Hamasaki, Sarah B. Doernberg, et al JAMA Published Online: August 13, 2025 doi: 10.1001/jama.2025.12543 Key Points Question  Is dalbavancin a superior treatment option for complicated Staphylococcus aureus bacteremia compared...

Research Letter  Characterization of Research Grant Terminations at the National Institutes of Health Michael Liu, Kushal T. Kadakia, Vishal R. Patel, et al JAMA 2025;334;(6):534-536. doi:10.1001/jama.2025.7707 The National Institutes of Health (NIH) recently initiated a series of grant terminations focused on topics not aligned with agency priorities.1 The scope of terminations, types of grants affected, and differ...