Original Investigation  March 26, 2025 Perioperative Penicillin and Cephalosporin Antibiotic Allergy Assessment and Testing: The PREPARE Pilot Randomized Clinical Trial Joseph Francis De Luca, Sara Vogrin, Natasha Elizabeth Holmes, et al JAMA Surg. Published online March 26, 2025. doi:10.1001/jamasurg.2025.0279 Key Points Question  Can penicillin and cephalosporin allergy delabeling be performed...

Original Investigation  Critical Care Medicine May 19, 2025 Cost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness Stephen Morris, Nazir I. Lone, Cathrine A. McKenzie, et al JAMA Netw Open. 2025;8(5):e2517533. doi:10.1001/jamanetworkopen.2025.17533 Key Points Question  What is the cost-effectiveness of dexmedetomidine, clonidine, and propofol for intravenous sedation in patients with ...

Original Investigation  Critical Care Medicine March 25, 2025 Recovery Potential in Patients After Cardiac Arrest Who Die After Limitations or Withdrawal of Life Support Jonathan Elmer, Patrick J. Coppler, Cecelia Ratay, et al JAMA Netw Open. 2025;8(3):e251714. doi:10.1001/jamanetworkopen.2025.1714 Key Points Question  How often do experts believe that there was recovery potential in patients who had limitations or withdrawal ...

Propranolol to Reduce Sedatives for Patients Receiving Mechanical Ventilation In ICU Mon, 24 Feb 2025 Critically ill patients require sedation for mechanical ventilation, with dexmedetomidine and propofol being the first-line options. However, the COVID-19 pandemic led to global shortages of propofol, while dexmedetomidine is costly and not ideal for deep sedation. Benzodiazepines, another alternative, are linked to higher mortality in sepsis, increase...

Research Care guided by tissue oxygenation and haemodynamic monitoring in off-pump coronary artery bypass grafting (Bottomline-CS): assessor blind, single centre, randomised controlled trial Jiange Han, Wenqian Zhai, Zhenhua Wu, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-082104 (Published 24 March 2025) Cite this as: BMJ 2025;388:e082104 Abstract Objective To assess whether perioperative management guided by near-infrared spectroscopy to d...

Original Investigation  Caring for the Critically Ill Patient May 19, 2025 Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial Timothy S. Walsh, Richard A. Parker, Leanne M. Aitken, et al JAMA. Published online May 19, 2025. doi:10.1001/jama.2025.7200 Key Points Question  Does primary sedation with dexmedetomidine or clonidine (α2-adrenergic receptor...

JAMA Data Brief  AI in Medicine March 21, 2025 Poll: Trust in AI for Accurate Health Information Is Low Avery Orrall; Andy Rekito JAMA. Published online March 21, 2025. doi:10.1001/jama.2024.22951 JAMA Medical News As more artificial intelligence (AI) tools become available online, people are struggling to differentiate truth from fiction, including when it comes to health information. As part of its ongoing survey o...

Precision in Nutrition Therapy In ICU Mon, 24 Feb 2025 A recent review discusses the challenges of evaluating nutrition strategies in critically ill patients through multicenter randomised controlled trials (RCTs). While smaller observational studies showed promise, many large-scale RCTs have failed to demonstrate effectiveness and have even indicated potential harm from some interventions. This discrepancy may stem from individual differences in patie...

Original Investigation  Infectious Diseases March 20, 2025 Midline Venous Catheter vs Peripherally Inserted Central Catheter for Intravenous Therapy: A Randomized Clinical Trial Ahmed Bentridi, Marie-France Giroux, Gilles Soulez, et al JAMA Netw Open. 2025;8(3):e251258. doi:10.1001/jamanetworkopen.2025.1258 Key Points Question  Is a midline venous catheter (MVC) a noninferior alternative to a...

Original Investigation  Critical Care Medicine March 21, 2025 External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis Elliot Long, Meredith L. Borland, Shane George, et al JAMA Netw Open. 2025;8(3):e251412. doi:10.1001/jamanetworkopen.2025.1412 Key Points Question  How do the Phoenix Sepsis Score and sepsis criteria perform in an external dataset? ...