Vasopressor Therapy and Intensive Care Patient Management In ICU Mon, 17 Feb 2025 Vasopressors are commonly used in critically ill patients to increase vascular tone in cases of severe hypotension with signs of altered tissue perfusion, such as poor skin perfusion, altered mental status, or decreased urine output—indicative of shock. Shock is associated with elevated lactate levels (>2 mmol/L) and can be classified into four types: hypovolaemic, car...

Original Investigation  March 29, 2025 Prothrombin Complex Concentrate vs Frozen Plasma for Coagulopathic Bleeding in Cardiac Surgery: The FARES-II Multicenter Randomized Clinical Trial Keyvan Karkouti, Jeannie L. Callum, Justyna Bartoszko, et al JAMA. Published online March 29, 2025. doi:10.1001/jama.2025.3501 Key Points Question  Is prothrombin complex concentrate (PCC) efficacious and safe co...

Original Investigation  Critical Care Medicine March 28, 2025 Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial Matthew A. Warner, Matthew L. Johnson, Andrew C. Hanson, et al JAMA Netw Open. 2025;8(3):e252353. doi:10.1001/jamanetworkopen.2025.2353 Key Points Question  Does a multifaceted anemia prevention and treatment bundle vs standard care imp...

ARTIFICIAL INTELLIGENCE IN ICU Editorial Using AI to detect and treat delirium Young M., Kotfis K. & Bellomo R. LATEST ARTICLES Original ESICM consensus-based recommendations for the management of very old patients in intensive care Beil M., Alberto L., Bourne R. S., et al. Serum chloride concentration and outcomes in adults receiving intravenous fluid therapy with a balanced crystalloid solution or 0.9% sodium chloride Ramanan M., Hammond N...

Original Investigation  Oncology March 27, 2025 Late-Onset Immune-Related Adverse Events After Immune Checkpoint Inhibitor Therapy Sienna M. Durbin, Leyre Zubiri, Katherine Perlman, et al JAMA Netw Open. 2025;8(3):e252668. doi:10.1001/jamanetworkopen.2025.2668 Key Points Question  What is the frequency of late-onset immune-related adverse events (irAEs) among patients treated with immune chec...

Editorial  May 19, 2025 The Case for Economic Analyses in Trials With a No Effect Primary Outcome Brian H. Cuthbertson, Gordon Rubenfeld JAMA Netw Open. 2025;8(5):e2517477. doi:10.1001/jamanetworkopen.2025.17477 In this edition of JAMA Network Open, the article “Cost-Effectiveness of α2-Agonists for Intravenous Sedation in Patients With Critical Illness”1 derives from an in-trial cost-utility analysis of a 3-drug regimen for...

Original Investigation  March 26, 2025 Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke: A Systematic Review and Meta-Analysis Writing Committee for the PERSIST Collaborators JAMA. Published online March 26, 2025. doi:10.1001/jama.2025.2033 Key Points Question  What is the long-term risk of stroke after transient ischemic attack (TIA) or minor stroke? Findings  In this systematic review a...

Invited Commentary  Surgery March 25, 2025 Robotic-Assisted Cholecystectomy—for Whom? David R. Urbach JAMA Netw Open. 2025;8(3):e251711. doi:10.1001/jamanetworkopen.2025.1711 To assess whether robotic-assisted cholecystectomy is superior to laparoscopic cholecystectomy in the prevention of bile duct injury, Mullens and colleagues1 conducted a retrospective study of 737 908 Medicare beneficiaries, including 295 807 in an experimental c...

Original Investigation  Caring for the Critically Ill Patient April 14, 2025 Use of Life Support and Outcomes Among Patients Admitted to Intensive Care Units Emily E. Moin, Nicholas J. Seewald, Scott D. Halpern JAMA. Published online April 14, 2025. doi:10.1001/jama.2025.2163 Key Points Question  How have intensive care unit (ICU) care and outcomes changed in the United States over the past decade? Findings  In th...

Editorial  May 19, 2025 The Search for the Single Best Sedative Edward T. Qian, Todd W. Rice JAMA. Published online May 19, 2025. doi:10.1001/jama.2025.7359 Critically ill patients receiving invasive mechanical ventilation often require continuous infusion of sedation to address pain and anxiety. The search for the single best sedative agent for critically ill patients has been the topic of investigations for decades. Propofol, a lipid-based ...