Editorial  March 30, 2025 Risk of Running—A Contemporary Look at Cardiac Arrest in Long-Distance Races Nimesh S. Patel, Mark S. Link JAMA. Published online March 30, 2025. doi:10.1001/jama.2025.3646 Millions of people participate in long-distance running, particularly marathons and half-marathons, annually.1While the health benefits of regular exercise are well established,2 long-distance running can cause significant cardiovascular stre...

Liberal vs Restrictive Transfusion Strategies in Subarachnoid Haemorrhage In ICU Mon, 10 Feb 2025 Spontaneous aneurysmal subarachnoid haemorrhage (SAH) is a serious cerebrovascular event contributing significantly to morbidity and mortality. It is often associated with anaemia, which can worsen brain injury through cerebral hypoxia, particularly when haemoglobin (Hb) levels drop below 5 g/dL.  In healthy brains, anaemia is compensated by increa...

SPECIAL ARTICLE Association between Wealth and Mortality in the United States and Europe Sara Machado, Ilias Kyriopoulos, John Orav, et al N Engl J Med 2025;392:1310-1319 Abstract BACKGROUND Amid growing wealth disparity, we have little information on how health among older Americans compares with that among older Europeans across the distribution of wealth. METHODS We performed a longitudinal, retrospective cohor...

Editorial  March 29, 2025 Is It Time to Replace Plasma With Prothrombin Complex Concentrate in Cardiac Surgery? Ryan Wang, Elliott Bennett-Guerrero JAMA. Published online March 29, 2025. doi:10.1001/jama.2025.3644 Bleeding after cardiac surgery with cardiopulmonary bypass is associated with adverse clinical outcomes and increased resource utilization. Broadly speaking, this bleeding can be due to inadequate surgical hemostasis or microvascula...

Original Investigation  Nephrology April 2, 2025 Cost-Effectiveness of Team-Based Coaching With Surveillance for Prevention of Acute Kidney Injuries David Xiao, Sharon E. Davis, Caroline M. Godfrey, et al JAMA Netw Open. 2025;8(4):e252503. doi:10.1001/jamanetworkopen.2025.2503 Key Points Question  What is the cost-effectiveness of interventions for implementing protocols for preventing contra...

Original Investigation  March 31, 2025 Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions: A Systematic Review and Meta-Analysis Carolina Graña Possamai, Guillaume Cabanac, Elodie Perrodeau, et al JAMA Intern Med. Published online March 31, 2025. doi:10.1001/jamainternmed.2025.0256 Key Points Question  Do retracted studies impact results of systematic reviews...

Serum Cardiac Troponin Elevation and Sepsis Mortality  In Sepsis Mon, 17 Feb 2025 Sepsis, as defined by Sepsis-3, is a life-threatening organ dysfunction caused by a dysregulated response to infection, with high mortality rates, especially in septic shock. Sepsis can cause acute myocardial injury, and high-sensitivity cardiac troponin (hs-cTn) assays are increasingly used to detect cardiac injury in these patients. While previous studies linked el...

Invited Commentary  Critical Care Medicine March 28, 2025 Active Prevention and Treatment of Post–Critical Illness Anemia—Is It Time for Large Effectiveness Trials? Timothy S. Walsh JAMA Netw Open. 2025;8(3):e252368. doi:10.1001/jamanetworkopen.2025.2368 Anemia is prevalent following critical illness and is associated with delayed recovery, functional impairments, and reduced quality of life.1 Evidence tells us that restrict...

Status of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey Christian S. Scheer,  Evangelos J. Giamarellos-Bourboulis,  Ricard Ferrer, et al Am J Respir Crit Care Med Vol 211, Iss 4, pp 587–599, Apr 2025 DOI: 10.1164/rccm.202406-1167OC Abstract Rationale: Early detection, standardized therapy, adequate infrastructure, and strategies for quality improvement should constitute essential components of every hospital’s ...

Original Investigation  March 30, 2025 Cardiac Arrest During Long-Distance Running Races Jonathan H. Kim, Austin J. Rim, James T. Miller, et al JAMA. Published online March 30, 2025. doi:10.1001/jama.2025.3026 Key Points Question  What is the contemporary incidence of cardiac arrest and death among marathon and half-marathon runners in the US? Findings  In this case series and cohor...