The Future of Extracorporeal Care In ICU Tue, 4 Mar 2025 The incidence of long COVID is estimated to be between 6% and 40%. This highlights the need for ongoing care beyond initial survival. However, healthcare often focuses on survival as a binary outcome rather than considering the long-term recovery process, which can range from full recovery to ongoing dependence on institutional care and rehabilitation. There is an increasing need to address the c...

Original Investigation  Critical Care Medicine April 8, 2025 Post–Intensive Care Syndrome and Caregiver Burden: A Post Hoc Analysis of a Randomized Clinical Trial Soojung Ahn, Marianna LaNoue, Han Su, et al JAMA Netw Open. 2025;8(4):e253443. doi:10.1001/jamanetworkopen.2025.3443 Key Points Question  What is the long-term association between patient post–intensive care syndrome (PICS) and care...

Invited Commentary  Cardiology April 2, 2025 What’s Missing From Value-Based Care—Accounting for the Costs and Benefits of Quality Improvement Donald E. Casey Jr JAMA Netw Open. 2025;8(4):e252510. doi:10.1001/jamanetworkopen.2025.2510 Current estimated direct and indirect economic cost of cardiovascular diseases from 2019 to 2020 was $422.3 billion with coronary heart disease (CHD) accounting for more than 40% of deaths attributable to dis...

Original Investigation  Obstetrics and Gynecology April 9, 2025 Pregnancy-Related Deaths in the US, 2018-2022 Yingxi Chen, Meredith S. Shiels, Tarsicio Uribe-Leitz, et al JAMA Netw Open. 2025;8(4):e254325. doi:10.1001/jamanetworkopen.2025.4325 Key Points Question  What is the pattern of pregnancy-related deaths in the US? Findings  In this cross-sectional analysis of 6283 pregnan...

Impact of Postoperative Sepsis on Dementia In Sepsis Mon, 10 Feb 2025 Dementia is a progressive neurodegenerative disease with growing public health and economic implications. In 2019, 57.4 million people had dementia worldwide, a number projected to reach 152.8 million by 2050. The global financial burden is substantial, estimated at $1.31 trillion annually. As dementia prevalence rises, increased healthcare resources and preventive strategies will be...

Editorial  March 31, 2025 Mitigating the Impact of Retracted Studies in the Medical Literature Cary P. Gross, Annette Flanagin, Eli N. Perencevich, et al JAMA Intern Med. Published online March 31, 2025. doi:10.1001/jamainternmed.2025.0251 Medical publishing, and the scientific research ecosystem in general, face substantial challenges. Some are external, ranging from a relative decrease in research funding, to i...

Original Investigation  Pediatrics April 9, 2025 Multimodal Monitoring of Hemodynamics in Neonates With Extremely Low Gestational Age: A Randomized Clinical Trial Renjini Lalitha, Eyad Bitar, Matthew Hicks, et al JAMA Netw Open. 2025;8(4):e254101. doi:10.1001/jamanetworkopen.2025.4101 Key Points Question  Does multimodal hemodynamic assessment during the transitional period (first 72 hours of...

Extracorporeal Blood Purification in Critically Ill Paediatric Patients In ICU Mon, 10 Feb 2025 Extracorporeal blood purification therapies (EBPTs) use extracorporeal circuits to remove or modulate circulating substances for organ support and detoxification. These therapies include renal replacement therapy, ultrafiltration, haemoadsorption, and plasma therapies. Recent advances in technology have expanded EBPTs from single-organ to multiple-organ supp...

Original Investigation  Health Informatics June 9, 2020 Association of Electronic Health Record Use With Physician Fatigue and Efficiency Saif Khairat, Cameron Coleman, Paige Ottmar, et al JAMA Netw Open. 2020;3(6):e207385. doi:10.1001/jamanetworkopen.2020.7385 Key Points Question  What is the association between electronic health record use and physician fatigue and efficiency? Findings&n...

Research Letter  Nephrology March 5, 2025 Predicting Contrast-Associated Acute Kidney Injury Yunlin Feng, Min Jun, Amanda Y. Wang, et al JAMA Netw Open. 2025;8(3):e250107. doi:10.1001/jamanetworkopen.2025.0107 Introduction Contrast-associated acute kidney injury (CA-AKI), defined as AKI after exposure to a diagnostic or therapeutic radio-contrast agent,1 is an important clinical problem.2 CA-...