Adjuvant Therapies for Haemorrhagic Shock In ICU Tue, 8 Apr 2025 Severe traumatic injuries cause 4.4 million deaths globally each year, with haemorrhage responsible for 35–40% of these deaths, making it the second leading cause after brain injuries. Haemorrhagic deaths occur rapidly, often before hospital arrival, necessitating fast, pre-hospital interventions like haemostatic dressings, tourniquets, hypothermia control, tranexamic acid, calcium manage...

Effects of Janus kinase inhibitors in adults admitted to hospital due to COVID-19: a systematic review and individual participant data meta-analysis of randomised clinical trials Alain Amstutz, Stefan Schandelmaier, Hannah Ewald, et al Lancet Respir Med 2025; 13: 530-544 https://doi.org/10.1016/S2213-2600(25)00055-4 Summary Background Evidence from randomised clinical trials (RCTs) of Janus kinase (JAK) inhibitors—compared with usual care or placebo—in a...

Estimated undertreatment of carbapenem-resistant Gram-negative bacterial infections in eight low-income and middle-income countries: a modelling study Anant Mishra, Rahul Dwivedi, Kim Faure, et al Lancet Infect Dis Available online 30 April 2025 https://doi.org/10.1016/S1473-3099(25)00108-2 Summary Background Carbapenem-resistant Gram-negative (CRGN) bacterial infections are an urgent health threat, especially in low-income and middle-income countries (L...

ONLINE FIRST (FREE ACCESS) ICU TOOLBOX What's New in Intensive Care Acute kidney injury: when and how to start renal replacement therapyBarbar S. D., Wald R. & Quenot J.-P. STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Nutrition and metabolic control for ICU patientsGunst J., Egi M. & Van den Berghe G. LATEST ARTICLES Original ESICM—ESPNIC international expert consensus on quantitative lung ultrasound in intens...

Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Infect Dis Available online 15 May 2025 https://doi.org/10.1016/S1473-3099(25)00093-3 Summary Background Molnupiravir and nirmatrelvir–ritonavir are oral antivirals that have shown efficacy in preventing disease progression in outp...

Rationale for Early Arginine-Vasopressin Administration  In ICU Thu, 27 Mar 2025 The basics of vasopressor support and advanced considerations regarding its early use in intensive care settings. Introduction The use of vasopressors in critical care is a crucial aspect of haemodynamic management. While norepinephrine remains the primary agent of choice, the role of other vasopressors such as vasopressin has gained increasing attention. This discu...

Invited Commentary  May 28, 2025 Association of Familiarity of the Surgeon-Anesthesiologist Dyad With Major Morbidity After Surgery Jasmine Hwang, Rachel R. Kelz JAMA Surg. Published online May 28, 2025. doi:10.1001/jamasurg.2025.1376 We know patients do better when cared for by high-performing teams. Enhanced communication, trust, and experience contribute to the success of effective teams. These attributes are easier to achieve among teamma...

Original Investigation  Geriatrics May 30, 2025 Parental Education, Own Education, and Cognitive Function in Middle-Aged and Older Adults Shengyu Luo, Weiqing Chen, Wanting Hu, et al JAMA Netw Open. 2025;8(5):e2513036. doi:10.1001/jamanetworkopen.2025.13036 Key Points Question  Are maternal and paternal education associated with cognitive declines in middle-aged and older adults, and do individuals’ own education mediate these...

European Sepsis Care Survey: Sepsis Care in European Hospitals In Sepsis Thu, 3 Apr 2025 Sepsis remains a major global health issue, with nearly 49 million cases and 11 million deaths annually. International guidelines emphasise routine screening and standardised treatment protocols for high-risk patients. The World Health Assembly’s 2017 Resolution 70.7 and the G7 Health Ministers’ 2022 statement have called for enhanced prevention, diagnosis, and man...

Special Communication  May 29, 2025 Platelet Transfusion2025 AABB and ICTMG International Clinical Practice Guidelines Ryan A. Metcalf, Susan Nahirniak, Gordon Guyatt, et al JAMA. Published online May 29, 2025. doi:10.1001/jama.2025.7529 Abstract Importance  Platelet transfusion is a frequent procedure with benefits and risks. Objective  To provide recommendations in adult and pedia...