Research Letter  Randomized Experiment of Recruitment Letter Design to Maximize Clinical Trial Enrollment Niklas Dyrby Johansen, David Preiss, Marion Mafham, et al JAMA Published Online: June 25, 2025 doi: 10.1001/jama.2025.9170 Most new medical therapies only offer small to moderate benefits above high-level standard care and require increasingly large trials to demonstrate efficacy in light of generally de...

Burden of Brain Tissue Hypoxia, Metabolic Dysfunction in SAH  In ICU Mon, 28 Apr 2025 Non-traumatic subarachnoid haemorrhage (SAH) is a significant cause of death and disability globally, with an incidence of around 6 per 100,000 person-years. The initial treatment focuses on early aneurysm repair to prevent re-bleeding and reduce early brain injury risk. Management also addresses secondary brain injuries, including hydrocephalus, elevated intracr...

JOURNAL ARTICLE Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis Stefan Hatzl, Christina Geiger, Lisa Kriegl, et al Clin Infect Dis 2025: 80: 1080-1087 https://doi.org/10.1093/cid/ciae633 Abstract Background Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors. Due to the difficulty of ...

Original Investigation  AI in Medicine Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning Gregory Holste, Evangelos K. Oikonomou, Márton Tokodi, et al JAMA Published Online: June 23, 2025 doi: 10.1001/jama.2025.8731 Key Points Question  Can artificial intelligence (AI) fully automate echocardiogram interpretation? Findings  This study reports the dev...

Non-Burn Dermatological Emergencies in Critical Care In ICU Tue, 22 Apr 2025 Non-burn dermatologic emergencies, although less common than burn injuries, are associated with high morbidity and mortality due to the extensive loss of the skin barrier. These conditions often mimic burn-related pathophysiology and demand urgent, multidisciplinary care. Optimal outcomes are typically achieved at specialised burn centres, but limited availability means that i...

Original Investigation  Emergency Medicine Serious Illness Conversations in the Emergency Department for Older Adults With Advanced Illnesses: A Randomized Clinical Trial Kei Ouchi, Susan D. Block, Dorene M. Rentz, et al JAMA Netw Open 2025;8;(6):e2516582. doi:10.1001/jamanetworkopen.2025.16582 Key Points Question  Does an emergency department (ED)–based intervention to discuss serious illness care goals ...

Research Letter  Continuous Medical Knowledge Assessment Progress Report Score and Hospitalized Patient Outcomes Bradley M. Gray, Jonathan L. Vandergrift, Rebecca S. Lipner, et al JAMA Intern Med Published Online: June 16, 2025 doi: 10.1001/jamainternmed.2025.1730 The American Board of Internal Medicine started offering a Longitudinal Knowledge Assessment (LKA) in 2022 as an alternative to the 10-year long-f...

Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST) Hakim-Moulay Dehbi, Urs Fischer, Signild Åsberg, et al Lancet Available online 23 June 2025 https://doi.org/10.1016/S0140-6736(25)00439-8 Summary Background The optimal timing of oral anticoagulation for prevention of early ischaemic ...

Peri-Intubation Adverse Events and Clinical Outcomes In ICU Tue, 22 Apr 2025 Tracheal intubation (TI) is a critical procedure used in emergency departments (EDs) and ICUs worldwide, though it carries significant risks, especially in resource-limited settings. Major adverse events (MAEs) like haemodynamic instability, severe hypoxaemia, and cardiac arrest are common during the peri-intubation period and are associated with worse patient outcomes. Critic...

Original Investigation  April 23, 2025 Long-Term Postoperative Outcomes by Surgeon Gender and Patient-Surgeon Gender Concordance in the US Ryo Ikesu, Hiroshi Gotanda, Tara A. Russell, et al JAMA Surg. Published online April 23, 2025. doi:10.1001/jamasurg.2025.0866 Key Points Question  Are long-term postoperative outcomes different by surgeon gender and patient-surgeon gender concordance? Find...