Invited Commentary  Public Health Lung Cancer Screening in Lower-Risk Individuals—Less Can Be More Carl Martin Tammemägi JAMA Netw Open 2025;8;(7):e2523050. doi:10.1001/jamanetworkopen.2025.23050 Although evidence demonstrating the efficacy of computed tomographic lung screening (CTLS) is established, global uptake of CTLS has been slow, and the optimal methods of implementing CTLS have not been determined and may vary in different populations. One of ...

Post-Traumatic Stress Disorder in ICU Survivors In ICU Mon, 12 May 2025 Survival rates in intensive care have improved, but about 20% of ICU survivors develop post-traumatic stress disorder (PTSD), which often goes undiagnosed and can severely impact quality of life, work, and health. Contributing factors include life-threatening experiences, invasive treatments, isolation, and loss of control. Early screening and targeted interventions are crucial to ...

Original Investigation  Infectious Diseases Microbiota Transplantation Among Patients Receiving Long-Term Care: The Sentinel REACT Nonrandomized Clinical Trial Michael H. Woodworth, Ahmed Babiker, Radhika Prakash-Asrani, et al JAMA Netw Open 2025;8;(7):e2522740. doi:10.1001/jamanetworkopen.2025.22740 Key Points Question  Is fecal microbiota transplantation (FMT) acceptable and safe for long-term acute car...

Original Investigation  Public Health Computed Tomographic Screening Intervals for Patients at Moderate Risk of Lung Cancer Koen de Nijs, Harry J. de Koning, Pianpian Cao, et al JAMA Netw Open 2025;8;(7):e2523044. doi:10.1001/jamanetworkopen.2025.23044 Key Points Question  Can the benefits of lung cancer screening be preserved while reducing the burden by adapting the annual screening interval to age, sex...

Phosphate-Sparing Solution to Prevent Hypophosphataemia in Patients Undergoing CRRT In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Phosphate-based solutions used during continuous renal replacement therapy (CRRT) significantly reduce the incidence of hypophosphataemia in critically ill patients. These solutions are safe, improve phosphate balance, and may shorten ICU stay and ventilation duration, though further multice...

Noninvasive Ventilation vs High-Flow Nasal Oxygen After Extubation In ICU Mon, 12 May 2025 In ICUs, extubation decisions are challenging, as 20-30% of patients experience post-extubation respiratory failure, with 10-15% requiring reintubation. Reintubation has high mortality rates and is a key patient outcome in the post-extubation period.  Noninvasive ventilation (NIV) and high-flow nasal oxygen (HFNO) therapies, when applied immediately after...

Original Investigation  Statistics and Research Methods Predictive Modeling of Heterogeneous Treatment Effects in RCTs: A Scoping Review Joe V. Selby, Carolien C. H. M. Maas, Bruce H. Fireman, et al JAMA Netw Open 2025;8;(7):e2522390. doi:10.1001/jamanetworkopen.2025.22390 Key Points Question  How often has the 2020 Predictive Approaches to Treatment Heterogeneity (PATH) Statement been cited in published ...

LATEST ISSUE IN MEMORIAM In Memoriam Rinaldo Bellomo: A RemembranceKellum J. A., Ostermann  M. & Ronco C. Rinaldo Bellomo: relentless architect of modern intensive careForni L. G., Hodgson C. & Prowle J. R. ICU TOOLBOX Editorial From bedside to data and back to bedside: why do we need better data to perform trauma phenotyping and improve trauma care?Gauss T., Bouzat P .& Josse J. The Doppler combined assessment of splanchnic perfusion a...

Original Investigation  Health Informatics Operationalization of Artificial Intelligence Applications in the Intensive Care Unit: A Systematic Review Willemijn E. M. Berkhout, Julia J. van Wijngaarden, Jessica D. Workum, et al JAMA Netw Open 2025;8;(7):e2522866. doi:10.1001/jamanetworkopen.2025.22866 Key Points Question  What is the current state of artificial intelligence (AI) use in intensive care units...

Pathophysiological Role and Management of Carbon Dioxide in Acute Brain Injury In ICU Mon, 12 May 2025 Maintaining proper cerebral oxygen delivery is crucial for preventing secondary ischaemic injury in patients with acute brain injuries (ABI). Arterial carbon dioxide tension (PaCO₂) significantly influences cerebral blood flow (CBF). When intracranial pressure (ICP) is not elevated, adjusting PaCO₂ to an optimal level can support sufficient cerebral o...