Tocilizumab, Sarilumab and Anakinra in Critically Ill Patients With COVID-19 In ICU Thu, 22 May 2025 Both corticosteroids and interleukin-6 receptor antagonists (IL-6ra) -  tocilizumab and sarilumab - improve survival and reduce organ support needs in hospitalised COVID-19 patients, but their comparative effectiveness is unclear. Alternative treatments may be needed due to drug access issues.  Interleukin-1 (IL-1), involved in acute inflam...

Original Investigation  Germicidal UV Light and Incidence of Acute Respiratory Infection in Long-Term Care for Older Adults: A Randomized Clinical Trial Andrew P. Shoubridge, Amanda Brass, Maria Crotty, et al JAMA Intern Med Published Online: July 28, 2025 doi: 10.1001/jamainternmed.2025.3388 Key Points Question  Can germicidal UV light (GUV) appliances in common spaces reduce the incidence of a...

Editorials The pitfalls of diagnostic self-tests Jessica Watson, Margaret McCartney BMJ 2025; 390 doi: https://doi.org/10.1136/bmj.r1476 (Published 23 July 2025)Cite this as: BMJ 2025;390:r1476 Tests should be clinically useful and part of an evidence based pathway Rapid advances in diagnostic technology, coupled with persuasive advertising, have resulted in a surge of direct-to-consumer self-tests, often sold under the banner of “wellness.” Marketed as too...

Research Direct-to-consumer self-tests sold in the UK in 2023: cross sectional review of regulation and evidence of performance Bethany Hillier, Jonathan J Deeks, Joseph Alderman, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-085547 (Published 23 July 2025)Cite this as: BMJ 2025;390:e085547 Abstract Objectives To review the evidence base, clinical performance claims, and usability and safety of self-t...

Deciphering Sepsis: Transforming Diagnosis and Treatment In Sepsis Mon, 17 Feb 2025 Sepsis is a major but often overlooked cause of death and disability. In 2017, there were an estimated 48.9 million cases of sepsis, causing 11 million deaths worldwide. Sepsis is more common in lower-income regions, and its incidence is expected to rise as populations age. Severe forms of sepsis, such as septic shock, have high mortality rates, and even survivors face ...

Research Direct-to-consumer self-tests sold in the UK in 2023: cross sectional review of information on intended use, instructions for use, and post-test decision making Clare Davenport, Alex Richter, Bethany Hillier, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-085546 (Published 23 July 2025)Cite this as: BMJ 2025;390:e085546 Abstract Objectives To review the information provided for self-test devices sold in high street shops in the UK a...

Research Special Paper Impact of physician assistants on quality of care: rapid review Nicola Cooper, Steven Agius, Kate Freeman, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-086358 (Published 03 July 2025)Cite this as: BMJ 2025;390:e086358 Abstract Objective To determine the impact of physician assistants, compared with physicians, on quality of care in the context of an ongoing UK policy review. Design Rapid systematic revie...

Original Investigation  Infectious Diseases Adherence to Quality-of-Care Indicators and Mortality Outcomes in Patients With MRSA Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial Russel Lee, Yanan Zhu, Neela J. Rai, et al JAMA Netw Open 2025;8;(7):e2523220. doi:10.1001/jamanetworkopen.2025.23220 Key Points Question  Is clinical trial participation associated with improved adherence to 7 evidence-based quality-of-care...

GAME-OVER Study: Discarded Intravenous Medication in the ICU In ICU Mon, 24 Feb 2025 Healthcare systems contribute significantly to greenhouse gas emissions and environmental pollution. Climate change is affecting human health, prompting healthcare professionals to adopt more sustainable practices. Pharmaceuticals play a major role in healthcare-related emissions, with their supply chain depleting natural resources and contributing to global warming...

Research Letter  Statistics and Research Methods Confounder Selection in Observational Studies in High-Impact Medical and Epidemiological Journals Luis C. L. Correia, Rafael F. Mascarenhas, Felipe S. C. De Menezes, et al JAMA Netw Open 2025;8;(7):e2524176. doi:10.1001/jamanetworkopen.2025.24176 Introduction There is growing interest in using observational data and methods to evaluate questions about the causal effects o...