Optimal Timing of Anticoagulation After Ischaemic Stroke and Atrial Fibrillation In ICU Wed, 25 Jun 2025 Atrial fibrillation (AF) accounts for about 20–30% of ischaemic strokes. Direct oral anticoagulants (DOACs) are very effective for long-term secondary prevention of ischaemic stroke in AF patients, reducing the risk of intracranial haemorrhage by about half compared to vitamin K antagonists. However, the best timing to start anticoagulation after an...

Articles Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Meningitis & Antimicrobial Resistance Collaborators Summary Background Meningitis remains the leading infectious cause of neurological disabilities globally, disproportionately affecting children younger than 5 years and populations in the African meningitis belt. Whereas p...

Articles Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial Tuan Vu, Ali A Habib, Saiju Jacob, et al Lancet 2026; 407: 1712-1725 https://doi.org/10.1016/S0140-6736(26)00690-2 Summary Background Autoantibody-mediated complement activation drives pathology in acetylcholine receptor (AChR) antibody-positive generalised myasthenia gravis. Newer targeted therapies lower overa...

Viewpoint  AI in Medicine Artificial Intelligence Is Not the End of the Physician Canio Martinelli, Vincenzo Carnevale, Alfredo Ercoli, et al JAMA Published Online: April 29, 2026 doi: 10.1001/jama.2026.4356 No one predicted that artificial intelligence (AI) would first surpass physicians on empathy—diagnostic accuracy, perhaps; imaging interpretation, certainly. Empathy was supposed to be the last refuge...

#LIVES2025: Proactive vs Reactive Treatment of Hypotension During Surgery  In ICU Tue, 28 Oct 2025 Intraoperative hypotension affects over 75% of surgical patients and is linked to serious complications, including myocardial ischaemia, kidney failure, and death. Despite this prevalence, uncertainty remains about optimal blood pressure management during surgery.  The PRETREAT (Proactive vs Reactive Treatment of Hypo...

Original Investigation  MySurgeryRisk Model Predictions of Postoperative Complications and Mortality Yuanfang Ren, Esra Adiyeke, Ziyuan Guan, et al JAMA Surg Published Online: April 29, 2026 doi: 10.1001/jamasurg.2026.1112 Key Points Question  Will applying the MySurgeryRisk framework, originally developed and prospectively validated on a single-center dataset, to a large multicenter dataset enh...

EDITORIAL Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir H. Clifford Lane, Anthony S. Fauci N Engl J Med 2026;394:1649-1650 DOI: 10.1056/NEJMe2603127 The first cases of Covid-19 were reported at the end of 2019, and from January 20, 2020, to May 5, 2023, Covid-19 was considered to be a public health emergency of international concern. The total number of cases worldwide exceeded 1 million by early April 2020. In the United ...

Sepsis Onset Timing Linked to Mortality and Hospital Burden In Sepsis Tue, 10 Mar 2026 Sepsis remains a major cause of hospital mortality and prolonged admission, placing sustained pressure on clinical teams and hospital resources. The timing of sepsis onset during hospitalisation influences both detection and outcomes. Community-onset sepsis (COS), identified early in admission, and hospital-onset sepsis (HOS), developing later in a hospital stay, ref...

Original Investigation  Emergency Medicine Out-of-Hospital Cardiac Arrest Survival at Nighttime: A Nationwide Cohort Study Joshua M. Kimbrell, Tanner Smida, Judah A. Kreinbrook, et al JAMA Netw Open 2026;9;(4):e269828. doi:10.1001/jamanetworkopen.2026.9828 Key Points Question  Does out-of-hospital cardiac arrest resuscitation with nighttime prehospital response remain associated with low rates of survival u...

Invited Commentary  To Tube or Not to Tube—A Case for Early Enteral Nutrition Yuqi Zhang, Krista Haines, Suresh Agarwal JAMA Surg Published Online: April 22, 2026 doi: 10.1001/jamasurg.2026.1058 The early introduction of enteral feeding after surgery is well recognized as a cornerstone of Enhanced Recovery After Surgery (ERAS) protocols, consistently shown to reduce postoperative infections and mortality across multiple surgical domains. Although prior...