CORRESPONDENCE PUBLIC HEALTH ALERTS Andes Hantavirus Outbreak on a Cruise Ship, 2026 Andes Virus Outbreak Working Group N Engl J Med Published May 20, 2026 DOI: 10.1056/NEJMc2606496 TO THE EDITOR: On April 27, 2026, a man (later classified as Patient 3 in the outbreak) was medically evacuated to Ascension Island from the Dutch-flagged expedition cruise ship MV Hondius; he had severe acute respiratory infection (SARI) and reported shortness of bre...

Original Investigation  Antibiotic Therapy for Uncomplicated Acute Appendicitis: Ten-Year Follow-Up of the APPAC Randomized Clinical Trial Paulina Salminen, Roosa Salminen, Johanna Kallio, et al JAMA Published Online: January 21, 2026 doi: 10.1001/jama.2025.25921 Key Points Question  What is the long-term appendicitis recurrence and appendectomy rate in adult patients with uncomplicated acute ap...

ICU Dashboard Tracks Environmental Impact In ICU Tue, 13 Jan 2026 Green initiatives in Intensive Care Units (ICUs) increasingly focus on reducing the environmental footprint of routine care. Common measures include lowering glove use, replacing absorption pads with towels and shifting from disposable clothing to washable alternatives. While such actions are relatively simple to introduce, sustaining them requires structured monitoring. ICU teams need r...

Original Investigation  Infectious Diseases Single-Dose Liposomal Amphotericin Plus Fluconazole and Flucytosine for Cryptococcal Meningitis at a US Public Hospital Devin Clark, Javier Barranco-Trabi, Irene Goo, et al JAMA Netw Open 2026;9;(1):e2553552. doi:10.1001/jamanetworkopen.2025.53552 Key Points Question  What are the outcomes of the AMBITION protocol (single-dose liposomal amphotericin with 2 weeks of f...

Poetry and Medicine  28 Hours in the ICU Kaveh Danesh JAMA Published Online: March 11, 2026 doi: 10.1001/jama.2026.0660 I watch the sunrise I watch the sunset I watch the body fall apart while we tilt the horizon away from light knowing the sun setting in the West is rising in the East. I watch the sunrise I watch the sunrise I watch your pupils suspended midday between two horizons. [JAMA编者按]：ICU中的...

Research Weight regain after cessation of medication for weight management: systematic review and meta-analysis Sam West, Jadine Scragg, Paul Aveyard, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085304 (Published 07 January 2026)Cite this as: BMJ 2026;392:e085304 Abstract Objectives To quantify and compare the rate of weight regain after cessation of weight management medications (WMMs) in adults wi...

Redefining Sepsis Through Host–Microbe Dynamics In Sepsis Thu, 15 Jan 2026 Current approaches to classifying sepsis are limited because they rely too heavily on clinical features and host-only immune responses, while largely ignoring the role of the infecting microbes. Sepsis is a heterogeneous syndrome, and grouping patients based on clinical signs alone assumes a single underlying mechanism, which is often incorrect. This has hindered progress in und...

Research Letter  Impact of a Smartwatch Hypertension Notification Feature for Population Screening Jordana B. Cohen, Daniel K. Addo, Joshua A. Jacobs, et al JAMA 2026;335;(11):1001-1003. doi:10.1001/jama.2025.26925 In September 2025, the US Food and Drug Administration cleared the Apple Watch hypertension notification feature, which uses photoplethysmography signals to notify users of possible hypertension without using ...

Original Investigation  Coffee and Tea Intake, Dementia Risk, and Cognitive Function Yu Zhang, Yuxi Liu, Yanping Li, et al JAMA 2026;335;(11):961-974. doi:10.1001/jama.2025.27259 Key Points Question  Is long-term intake of caffeinated and decaffeinated coffee associated with risk of dementia and cognitive outcomes? Findings  In this prospective cohort study of 131 821 individuals from 2 cohorts ...

Invited Commentary  From Balanced Blood Products to Personalized Medicine in Acute Resuscitation of Trauma Patients Taylor E. Wallen, John B. Holcomb JAMA Surg Published Online: March 11, 2026 doi: 10.1001/jamasurg.2026.0195 Resuscitation of patients experiencing hemorrhagic shock has changed tremendously over the last 30 years, moving from crystalloid and red blood cells to balanced components, and now with whole blood (WB) administration gaining favo...