Original Investigation Nonregistration, Discontinuation, and Nonpublication of Randomized Trials: A Systematic Review Benjamin Speich, Ala Taji Heravi, Christof M. Schönenberger, et al JAMA Netw Open 2025;8;(9):e2524440. doi:10.1001/jamanetworkopen.2025.24440 Key Points Question  What percentage of randomized clinical trials (RCTs) are unregistered, prematurely discontinued, or unpublished? Findings  This systematic review assessing 3...

LLM Diagnostic Performance in Complex Critical Illness In ICU Wed, 11 Jun 2025 Large language models (LLMs) are increasingly used in healthcare for education, research, and clinical care. They have shown promise by passing all stages of the US Medical Licensing Exam and generating accurate, empathetic responses to patient queries, suggesting the potential to assist physicians in complex clinical decision-making, including differential diagnosis.  ...

Articles Profile of central line-associated bloodstream infections in adult, paediatric, and neonatal intensive care units of hospitals participating in a health-care-associated infection surveillance network in India: a 7-year multicentric study Rasna Parveen, Arpan Kumar Thakur, Sharad Srivastav, et al Lancet Global Health 2025; 13: e1564-e1573 https://doi.org/10.1016/S2214-109X(25)00221-9 Summary Background Central line-associated bloodstream infec...

Articles Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Infect Dis Available online 28 August 2025 https://doi.org/10.1016/S1473-3099(25)00361-5 Summary Background Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVE...

Comment Infections in long-term care: burden affirmed, action needed Philipp Kohler, Allison McGeer Lancet Infect Dis Available online 16 June 2025 https://doi.org/10.1016/S1473-3099(25)00287-7 In The Lancet Infectious Diseases, Enrico Ricchizzi and colleagues report the results of a year-long study of the incidence of health-care-associated infections (HAIs) in long-term care facilities (LTCFs) in nine European countries.1 Using prospective surve...

Atrial Fibrillation in Critical Illness In ICU Wed, 11 Jun 2025 Atrial fibrillation (AF) presents significant management challenges in the ICU. Pre-existing AF affects 10–20% of ICU patients, while new-onset AF (NOAF) occurs in 5–15% of critically ill individuals and up to 46% in those with septic shock. NOAF may be transient or indicate an underlying predisposition, complicating treatment decisions.  AF in critical illness is linked to worse o...

Articles Incidence of health-care-associated infections in long-term care facilities in nine European countries: a 12-month, prospective, longitudinal cohort study Enrico Ricchizzi, Elena Sasdelli, Anna Caterina Leucci, et al Lancet Infect Dis Available online 16 June 2025 https://doi.org/10.1016/S1473-3099(25)00217-8 Summary Background The number of older people in need of long-term care is increasing, and health-care-associated infections (HAIs) are...

Articles Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jiroveciipneumonia (PIC): a multicentre, double-blind, randomised controlled trial Virginie Lemiale, Matthieu Resche-Rigon, Yoann Zerbib, et al Lancet Respir Med 2025; 13: 800-808 https://doi.org/10.1016/S2213-2600(25)00125-0 Summary Background Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised patients has a hospital mortality rate of 30–5...

ORIGINAL ARTICLE High-Dose Influenza Vaccine to Reduce Hospitalizations Jacobo Pardo-Seco, Carmen Rodríguez-Tenreiro-Sánchez, Iago Giné-Vázquez, et al N Engl J Med Published August 30, 2025 DOI: 10.1056/NEJMoa2509834 Abstract BACKGROUND Superior protection against laboratory-confirmed influenza has been proved for high-dose inactivated influenza vaccine, as compared with the standard dose, among adults 65 years of age or older. However, data on the re...

Electronic Sepsis Screening and Mortality  In Sepsis Wed, 12 Mar 2025 Early recognition and treatment of sepsis are crucial for improving patient outcomes, leading to clinical guidelines recommending sepsis screening programmes. However, evidence supporting these programmes is limited. Observational studies suggest screening improves care processes, such as timely lactate measurement and antibiotic administration, and may reduce mortality. However...