Articles Global, regional, and national sepsis incidence and mortality, 1990–2021: a systematic analysis GBD 2021 Global Sepsis Collaborators Lancet Global Health 2025; 13: e2013-e2026 https://doi.org/10.1016/S2214-109X(25)00356-0 Summary Background The global burden of sepsis, a life-threatening dysregulated host response to infection leading to organ dysfunction, remains challenging to quantify. We aimed to comprehensively estimate the global, regio...

Editorial  The Importance of Real-World Evidence to Inform RSV Vaccine Guidance Anna Hung, Lona Mody JAMA Intern Med Published Online: November 24, 2025 doi: 10.1001/jamainternmed.2025.6364 Respiratory syncytial virus (RSV) is associated with increased risks of hospitalization and death in older adults with chronic conditions. To reduce risks in this population, 3 RSV vaccines are approved in adults 60 years and older. In June ...

Original Investigation  Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans Kristina L. Bajema, David P. Bui, Lei Yan, et al JAMA Intern Med Published Online: November 24, 2025 doi: 10.1001/jamainternmed.2025.6355 Key Points Question  What is the long-term effectiveness of a single respiratory syncytial virus (RSV) vaccine dose against RSV illness and associated hea...

Prevalence, Risk of Mortality of Antimicrobial Resistance - A Global Review In ICU Tue, 26 Aug 2025 Antimicrobial resistance (AMR) is a major global health threat, with rising prevalence worsened by the COVID-19 pandemic. Hospitals are particularly high-risk environments for AMR due to heavy antibiotic use and vulnerable patient populations. Contributing factors include increased virulence, reduced antibiotic effectiveness, improper dosing, and ageing ...

Articles Leveraging deep learning applied to chest radiograph images to identify individuals at high risk of chronic obstructive pulmonary disease: a retrospective model validation study Saman Doroodgar Jorshery, Jay Chandra, Anika S Walia, et al Lancet Digital Health 2025; 7: 100903 https://doi.org/10.1016/j.landig.2025.100903 Summary Background Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality, yet early detection remains ...

Articles Development and external validation of a clinical prediction model for new-onset atrial fibrillation in intensive care: a multicentre, retrospective cohort study Jonathan P Bedford, Oliver Redfern, Stephen Gerry, et al Lancet Digital Health 2025; 7: 100896 https://doi.org/10.1016/j.landig.2025.100896 Summary Background New-onset atrial fibrillation, a condition associated with adverse outcomes in the short and long term, is common in patients...

Original Investigation  Women's Health  Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease Christian Chan, Simon Sawhney, Sofia B. Ahmed, et al JAMA Intern Med Published Online: November 17, 2025 doi: 10.1001/jamainternmed.2025.5979 Key Points Question  Does the female survival advantage observed in the general populati...

Healthcare Costs After Sepsis In Sepsis Tue, 26 Aug 2025 Sepsis, a life-threatening condition caused by a dysregulated response to infection, is linked to high in-hospital mortality and healthcare costs. Survivors face increased risks of hospital readmission, cardiovascular disease, cognitive impairment, and long-term healthcare expenses. While previous reviews have examined initial hospitalisation costs and healthcare use post-sepsis, no systematic re...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT Editorial Best practices in airway management in critically ill adultsDe Jong, A., Jaber, S. & Myatra, S.N. LATEST ARTICLES OriginalPositive communication for decreasing burnout in intensive-care-unit staff: a cluster-randomized trialAzoulay, É., Myatra, S.N., Heras La Calle, G. et al. Characteristics of ventilator weaning in patients intubated for Guillain–Barré syndrome or myast...

Original Investigation  Immune Modulation by Personalized vs Standard Prehabilitation Before Major Surgery: A Randomized Clinical Trial Amélie Cambriel, Amy Tsai, Benjamin Choisy, et al JAMA Surg Published Online: November 12, 2025 doi: 10.1001/jamasurg.2025.4917 Key Points Question  How do personalized prehabilitation programs modulate the peripheral immune system in patients undergoing major e...