Original Investigation  Infectious Diseases Adherence to Quality-of-Care Indicators and Mortality Outcomes in Patients With MRSA Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial Russel Lee, Yanan Zhu, Neela J. Rai, et al JAMA Netw Open 2025;8;(7):e2523220. doi:10.1001/jamanetworkopen.2025.23220 Key Points Question  Is clinical trial participation associated with improved adherence to 7 evidence-based quality-of-care...

GAME-OVER Study: Discarded Intravenous Medication in the ICU In ICU Mon, 24 Feb 2025 Healthcare systems contribute significantly to greenhouse gas emissions and environmental pollution. Climate change is affecting human health, prompting healthcare professionals to adopt more sustainable practices. Pharmaceuticals play a major role in healthcare-related emissions, with their supply chain depleting natural resources and contributing to global warming...

Research Letter  Statistics and Research Methods Confounder Selection in Observational Studies in High-Impact Medical and Epidemiological Journals Luis C. L. Correia, Rafael F. Mascarenhas, Felipe S. C. De Menezes, et al JAMA Netw Open 2025;8;(7):e2524176. doi:10.1001/jamanetworkopen.2025.24176 Introduction There is growing interest in using observational data and methods to evaluate questions about the causal effects o...

Invited Commentary  Public Health Lung Cancer Screening in Lower-Risk Individuals—Less Can Be More Carl Martin Tammemägi JAMA Netw Open 2025;8;(7):e2523050. doi:10.1001/jamanetworkopen.2025.23050 Although evidence demonstrating the efficacy of computed tomographic lung screening (CTLS) is established, global uptake of CTLS has been slow, and the optimal methods of implementing CTLS have not been determined and may vary in different populations. One of ...

Post-Traumatic Stress Disorder in ICU Survivors In ICU Mon, 12 May 2025 Survival rates in intensive care have improved, but about 20% of ICU survivors develop post-traumatic stress disorder (PTSD), which often goes undiagnosed and can severely impact quality of life, work, and health. Contributing factors include life-threatening experiences, invasive treatments, isolation, and loss of control. Early screening and targeted interventions are crucial to ...

Original Investigation  Infectious Diseases Microbiota Transplantation Among Patients Receiving Long-Term Care: The Sentinel REACT Nonrandomized Clinical Trial Michael H. Woodworth, Ahmed Babiker, Radhika Prakash-Asrani, et al JAMA Netw Open 2025;8;(7):e2522740. doi:10.1001/jamanetworkopen.2025.22740 Key Points Question  Is fecal microbiota transplantation (FMT) acceptable and safe for long-term acute car...

Original Investigation  Public Health Computed Tomographic Screening Intervals for Patients at Moderate Risk of Lung Cancer Koen de Nijs, Harry J. de Koning, Pianpian Cao, et al JAMA Netw Open 2025;8;(7):e2523044. doi:10.1001/jamanetworkopen.2025.23044 Key Points Question  Can the benefits of lung cancer screening be preserved while reducing the burden by adapting the annual screening interval to age, sex...

Phosphate-Sparing Solution to Prevent Hypophosphataemia in Patients Undergoing CRRT In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Phosphate-based solutions used during continuous renal replacement therapy (CRRT) significantly reduce the incidence of hypophosphataemia in critically ill patients. These solutions are safe, improve phosphate balance, and may shorten ICU stay and ventilation duration, though further multice...

Noninvasive Ventilation vs High-Flow Nasal Oxygen After Extubation In ICU Mon, 12 May 2025 In ICUs, extubation decisions are challenging, as 20-30% of patients experience post-extubation respiratory failure, with 10-15% requiring reintubation. Reintubation has high mortality rates and is a key patient outcome in the post-extubation period.  Noninvasive ventilation (NIV) and high-flow nasal oxygen (HFNO) therapies, when applied immediately after...

Original Investigation  Statistics and Research Methods Predictive Modeling of Heterogeneous Treatment Effects in RCTs: A Scoping Review Joe V. Selby, Carolien C. H. M. Maas, Bruce H. Fireman, et al JAMA Netw Open 2025;8;(7):e2522390. doi:10.1001/jamanetworkopen.2025.22390 Key Points Question  How often has the 2020 Predictive Approaches to Treatment Heterogeneity (PATH) Statement been cited in published ...