Original Investigation  Proportional Sedation for Persistent Agitated Delirium in Palliative Care: A Randomized Clinical Trial David Hui, Allison De La Rosa, Jaw-Shiun Tsai, et al JAMA Oncol Published Online: July 31, 2025 doi: 10.1001/jamaoncol.2025.2212 Key Points Question  What is the impact of haloperidol and/or lorazepam on restlessness and agitation in patients with advanced cancer and per...

Original Investigation  Nurse-Led Family Support Intervention for Families of Critically Ill Patients: The FICUS Cluster Randomized Clinical Trial Rahel Naef, Marie-Madlen Jeitziner, Marco Riguzzi, et al JAMA Intern Med Published Online: July 28, 2025 doi: 10.1001/jamainternmed.2025.3406 Key Points Question  Does a nurse-led, interprofessional, multicomponent family support intervention in adult...

Original Investigation  Influenza-Associated Acute Necrotizing Encephalopathy in US Children Influenza-Associated Acute Necrotizing Encephalopathy (IA-ANE) Working Group JAMA Published Online: July 30, 2025 doi: 10.1001/jama.2025.11534 Key Points Question  What were the clinical characteristics, management approaches, and outcomes among children with influenza-associated acute necrotizing encephalopathy (ANE) in the US durin...

Tocilizumab, Sarilumab and Anakinra in Critically Ill Patients With COVID-19 In ICU Thu, 22 May 2025 Both corticosteroids and interleukin-6 receptor antagonists (IL-6ra) -  tocilizumab and sarilumab - improve survival and reduce organ support needs in hospitalised COVID-19 patients, but their comparative effectiveness is unclear. Alternative treatments may be needed due to drug access issues.  Interleukin-1 (IL-1), involved in acute inflam...

Original Investigation  Germicidal UV Light and Incidence of Acute Respiratory Infection in Long-Term Care for Older Adults: A Randomized Clinical Trial Andrew P. Shoubridge, Amanda Brass, Maria Crotty, et al JAMA Intern Med Published Online: July 28, 2025 doi: 10.1001/jamainternmed.2025.3388 Key Points Question  Can germicidal UV light (GUV) appliances in common spaces reduce the incidence of a...

Editorials The pitfalls of diagnostic self-tests Jessica Watson, Margaret McCartney BMJ 2025; 390 doi: https://doi.org/10.1136/bmj.r1476 (Published 23 July 2025)Cite this as: BMJ 2025;390:r1476 Tests should be clinically useful and part of an evidence based pathway Rapid advances in diagnostic technology, coupled with persuasive advertising, have resulted in a surge of direct-to-consumer self-tests, often sold under the banner of “wellness.” Marketed as too...

Research Direct-to-consumer self-tests sold in the UK in 2023: cross sectional review of regulation and evidence of performance Bethany Hillier, Jonathan J Deeks, Joseph Alderman, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-085547 (Published 23 July 2025)Cite this as: BMJ 2025;390:e085547 Abstract Objectives To review the evidence base, clinical performance claims, and usability and safety of self-t...

Deciphering Sepsis: Transforming Diagnosis and Treatment In Sepsis Mon, 17 Feb 2025 Sepsis is a major but often overlooked cause of death and disability. In 2017, there were an estimated 48.9 million cases of sepsis, causing 11 million deaths worldwide. Sepsis is more common in lower-income regions, and its incidence is expected to rise as populations age. Severe forms of sepsis, such as septic shock, have high mortality rates, and even survivors face ...

Research Direct-to-consumer self-tests sold in the UK in 2023: cross sectional review of information on intended use, instructions for use, and post-test decision making Clare Davenport, Alex Richter, Bethany Hillier, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-085546 (Published 23 July 2025)Cite this as: BMJ 2025;390:e085546 Abstract Objectives To review the information provided for self-test devices sold in high street shops in the UK a...

Research Special Paper Impact of physician assistants on quality of care: rapid review Nicola Cooper, Steven Agius, Kate Freeman, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-086358 (Published 03 July 2025)Cite this as: BMJ 2025;390:e086358 Abstract Objective To determine the impact of physician assistants, compared with physicians, on quality of care in the context of an ongoing UK policy review. Design Rapid systematic revie...