Optimising beta-lactam treatment in the ICU - expert consensus The French Society of Pharmacology and Therapeutics (SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (SFAR) have released guidelines on the optimisation of beta-lactam treatment in intensive care unit (ICU) patients. The two groups strongly recommend the use of personalised dosing, continuous or prolonged infusion and therapeutic drug monitoring when administering beta-lactam ant...

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study Madeleine K D Scott, Katie Quinn, Qin Li, et al Lancet Respir Med Published:March 29, 2019 DOI:https://doi.org/10.1016/S2213-2600(18)30508-3 Background There is an urgent need for biomarkers to better stratify patients with idiopathic pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical prese...

PROTINVENT study: protein intake timing and dose for the critically ill Optimal protein intake during critical illness is unknown. In order to achieve a personalised nutritional approach, Dutch researchers conducted the PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation (PROTINVENT) study. The study’s primary aim was to determine the best timing and dose of protein intake to support the lowest 6-month mortality...

Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial Jean-Pierre Frat, Jean-Damien Ricard, Jean-Pierre Quenot, et al Lancet Respir Med 2019; 7: 303-312 Background 背景 Non-invasive ventilation has never been compared with high-flow oxygen to determine whether it reduces the risk of se...

European guideline on managing post-traumatic bleeding: 5th edition An updated guideline on the management of significant bleeding and coagulopathy following major trauma has been released by the pan-European, multidisciplinary Task Force for Advanced Bleeding Care in Trauma. The document, published in the journal Critical Care, includes recommendations intended to guide the management of patients during the early phase of hospital care following traumatic injury. ...

Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR) Guilhaumou et al. Critical Care (2019) 23:104 https://doi.org/10.1186/s13054-019-2378-9 Guidelines 指南 First area. Pharma...

The role of post-ICU recovery clinics With multiple advances in critical care, more patients are given the chance to survive life-threatening illnesses such as sepsis. This growing cohort of patients, however, grapples with a new challenge – post-intensive care syndrome (PICS). A raft of symptoms, including muscle weakness, depression, anxiety, and posttraumatic stress disorder (PTSD), makes it difficult for patients with PICS to resume their prehospitalisation liv...

News Oxygen after surgery: review questions WHO advice that high levels reduce infection BMJ 2019; 364 doi: https://doi.org/10.1136/bmj.l777 (Published 18 February 2019)Cite this as: BMJ 2019;364:l777 World Health Organization guidelines on using high levels of oxygen during and after surgery have been questioned after claims that research by an Italian surgeon lacks credibility. Mario Schietroma of the University of L’Aquila in central Italy is the author of ...

Value-based incentive programmes and CAUTI rates Value-based incentive programmes (VBIPs) aim to drive improvements in quality and reduce costs by linking financial incentives or penalties to hospital performance. A new study evaluated the association of two U.S. federal VBIPs – the Hospital Value-Based Purchasing (VBP) Program and the Hospital-Acquired Condition Reduction Program (HACRP) – and catheter-associated urinary tract infections (CAUTIs) in the critical c...

Original Investigation|March 19, 2019 Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality Victor W. Zhong, Linda Van Horn, Marilyn C. Cornelis, et al JAMA. 2019;321(11):1081-1095. doi:10.1001/jama.2019.1572 Importance  背景 Cholesterol is a common nutrient in the human diet and eggs are a major source of dietary cholesterol. Whether dietary cholesterol or egg ...