Non-invasive ventilation versus high-flow nasal cannula oxygen therapy with apnoeic oxygenation for preoxygenation before intubation of patients with acute hypoxaemic respiratory failure: a randomised, multicentre, open-label trial Jean-Pierre Frat, Jean-Damien Ricard, Jean-Pierre Quenot, et al Lancet Respir Med 2019; 7: 303-312 Background 背景 Non-invasive ventilation has never been compared with high-flow oxygen to determine whether it reduces the risk of se...

European guideline on managing post-traumatic bleeding: 5th edition An updated guideline on the management of significant bleeding and coagulopathy following major trauma has been released by the pan-European, multidisciplinary Task Force for Advanced Bleeding Care in Trauma. The document, published in the journal Critical Care, includes recommendations intended to guide the management of patients during the early phase of hospital care following traumatic injury. ...

Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR) Guilhaumou et al. Critical Care (2019) 23:104 https://doi.org/10.1186/s13054-019-2378-9 Guidelines 指南 First area. Pharma...

The role of post-ICU recovery clinics With multiple advances in critical care, more patients are given the chance to survive life-threatening illnesses such as sepsis. This growing cohort of patients, however, grapples with a new challenge – post-intensive care syndrome (PICS). A raft of symptoms, including muscle weakness, depression, anxiety, and posttraumatic stress disorder (PTSD), makes it difficult for patients with PICS to resume their prehospitalisation liv...

News Oxygen after surgery: review questions WHO advice that high levels reduce infection BMJ 2019; 364 doi: https://doi.org/10.1136/bmj.l777 (Published 18 February 2019)Cite this as: BMJ 2019;364:l777 World Health Organization guidelines on using high levels of oxygen during and after surgery have been questioned after claims that research by an Italian surgeon lacks credibility. Mario Schietroma of the University of L’Aquila in central Italy is the author of ...

Value-based incentive programmes and CAUTI rates Value-based incentive programmes (VBIPs) aim to drive improvements in quality and reduce costs by linking financial incentives or penalties to hospital performance. A new study evaluated the association of two U.S. federal VBIPs – the Hospital Value-Based Purchasing (VBP) Program and the Hospital-Acquired Condition Reduction Program (HACRP) – and catheter-associated urinary tract infections (CAUTIs) in the critical c...

Original Investigation|March 19, 2019 Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality Victor W. Zhong, Linda Van Horn, Marilyn C. Cornelis, et al JAMA. 2019;321(11):1081-1095. doi:10.1001/jama.2019.1572 Importance  背景 Cholesterol is a common nutrient in the human diet and eggs are a major source of dietary cholesterol. Whether dietary cholesterol or egg ...

Research True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study Mark Mariathas, Rick Allan, Sanjay Ramamoorthy, et al BMJ 2019;364:l729 Abstract Objective 目的 To determine the distribution, and specifically the true 99th centile, of high sensitivity cardiac troponin I (hs-cTnI) for a whole hospital population by applying the hs-cTnI assay currently used routinely at a large teaching hos...

Original Investigation |March 19, 2019 Levels of Evidence Supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018 Alexander C. Fanaroff, Robert M. Califf, Stephan Windecker, et al JAMA. 2019;321(11):1069-1080. doi:10.1001/jama.2019.1122 Importance  背景 Clinical decisions are ideally based on evidence generated from multiple randomized control...

Declining rate of ARDS-related mortality There have been multiple advances in the management of acute respiratory distress syndrome (ARDS), but the temporal trends in ARDS-related mortality are not well known. Conservative fluid management strategy for ARDS, in particular, has been extensively studied and is increasingly being used in clinical practice. However, it is largely unknown whether this changing practice parallels with the improvement in survival outcome....