Original Investigation Pediatrics Evaluation of Oxygen Saturation Index Compared With Oxygenation Index in Neonates With Hypoxemic Respiratory Failure Hemananda K. Muniraman,  Ashley Y. Song, Rangasamy Ramanathan, et al JAMA Netw Open. 2019;2(3):e191179. doi:10.1001/jamanetworkopen.2019.1179 Abstract Importance 背景 Oxygenation index (OI), an invasive measurement, is routinely used as a marker of severity of h...

Original Investigation Critical Care Medicine Prevalence, Underlying Causes, and Preventability of Sepsis-Associated Mortality in US Acute Care Hospitals Chanu Rhee, Travis M. Jones, Yasir Hamad, et al JAMA Netw Open. 2019;2(2):e187571. doi:10.1001/jamanetworkopen.2018.7571 Abstract Importance 背景 Sepsis is present in many hospitalizations that culminate in death. The contribution of sepsis to these deaths, and the extent to which they are preventable, ...

Management of obese patients with ARDS At least one fifth of all patients admitted to the ICU are obese, and these patients are at risk of developing lung de-recruitment and then atelectasis. Moreover, the incidence of acute respiratory distress syndrome (ARDS) is increased in obese patients. A major challenge of the critical care management of obese patients is successful respiratory system management. However, while obesity contributes to many diseases and is ...

Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health Challenging the One-Hour Sepsis Bundle Annahieta Kalantari, DO; Salim R. Rezaie, MD Western J Emerg Med. 2019;20(2):185-190.  In April 2018, the Surviving Sepsis Campaign (SSC) released an updated sepsis bundle, which combines directives previously listed in the three-hour and six-hour bundles. The authors discussed the reasoning and evidence supporting these changes. Howe...

Intensive Care Medicine ONLINE FIRST (FREE ACCESS) Editorial ~ Jason Roberts -  Personalized antibiotic dosing for the critically illFrom the Inside ~ Alberto García-Salido - A thirty second pauseOriginal ~ F Raymond - Whole genome sequencing reveals that genetic conditions are frequent in intensively ill childrenOriginal ~ Teresa May - Variability in functional outcome and treatment practices by treatment center aft...

JAMA Clinical Guidelines Synopsis March 25, 2019 Management of Patients With Severe Aortic Stenosis With Transcatheter Valve Replacement AbdulRahman Dia, Adam S. Cifu, Atman P. Shah JAMA. 2019;321(15):1527-1528. doi:10.1001/jama.2019.1336 Guideline title 指南标题 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease 2014 AHA/ACC 心脏瓣膜病患者诊治指南的...

An environmental cleaning bundle and health-care-associated infections in hospitals (REACH): a multicentre, randomised trial Brett G Mitchell, Lisa Hall, Nicole White,  et al Lancet Infect Dis 2019; 19: 410-418 Background 背景 The hospital environment is a reservoir for the transmission of microorganisms. The effect of improved cleaning on patient-centred outcomes remains unclear. We aimed to evaluate the effectiveness of an environmental cleaning bundle ...

Optimising beta-lactam treatment in the ICU - expert consensus The French Society of Pharmacology and Therapeutics (SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (SFAR) have released guidelines on the optimisation of beta-lactam treatment in intensive care unit (ICU) patients. The two groups strongly recommend the use of personalised dosing, continuous or prolonged infusion and therapeutic drug monitoring when administering beta-lactam ant...

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study Madeleine K D Scott, Katie Quinn, Qin Li, et al Lancet Respir Med Published:March 29, 2019 DOI:https://doi.org/10.1016/S2213-2600(18)30508-3 Background There is an urgent need for biomarkers to better stratify patients with idiopathic pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical prese...

PROTINVENT study: protein intake timing and dose for the critically ill Optimal protein intake during critical illness is unknown. In order to achieve a personalised nutritional approach, Dutch researchers conducted the PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation (PROTINVENT) study. The study’s primary aim was to determine the best timing and dose of protein intake to support the lowest 6-month mortality...