Effects of Sedatives and Opioids on Patient Ventilator Asynchrony Patient-ventilator asynchrony is frequent during invasive mechanical ventilation. If patient-ventilator interaction is poor, it can prolong the duration of mechanical ventilation and can also result in longer ICU and hospital stay as well as increased mortality. It is thus important to optimise patient-ventilator interaction.  There are many factors that could affect patient-ventilator interaction...

COMMENT|ONLINE FIRST Simplified control measures for ESBL-producing Enterobacteriacae? Jean-Christophe Lucet, Jean-Ralph Zahar Lancet Infect Dis Published:August 23, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30412-8 Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriacae have disseminated worldwide, with very high prevalence in countries of low and middle income1 and a roughly 10% prevalence in the community and at hospital admission in high-inco...

Outcomes of ABCDE Bundle in Mechanically Ventilated Patients Increasing focus on ICU utilisation and survivorship has also resulted in a greater focus on the long-term consequences of critical illness. Post Intensive Care Syndrome (PICS) is characterised by physical, cognitive, and emotional manifestations and can have a long-lasting impact on survivors of ICU as well as their families and caregivers.  The ABCDEF bundle is an organisational approach that is used...

ARTICLES|ONLINE FIRST Contact precautions in single-bed or multiple-bed rooms for patients with extended-spectrum β-lactamase-producing Enterobacteriaceae in Dutch hospitals: a cluster-randomised, crossover, non-inferiority study Marjolein F Q Kluytmans-van den Bergh, Patricia C J Bruijning-Verhagen, Prof Christina M J E Vandenbroucke-Grauls, et al. Lancet Infect Dis Published:August 23, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30262-2 Summary Backgro...

Untangling the Infusion Confusion Many patients in the ICU receive multiple IV infusions. This can lead to significant confusion because infusions look quite similar, and a patient with multiple infusions tends to be surrounded by associated components such as bags, tubing, pumps, etc. There is often a lack of information along the infusion pathway, which can lead to confusion. For example, if an infusion change is required, the healthcare provider must reconcile t...

Original Investigation September 3, 2019 N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial Lewis J. Radonovich Jr, Michael S. Simberkoff, Mary T. Bessesen, et al JAMA. 2019;322(9):824-833. doi:10.1001/jama.2019.11645 Abstract Importance 背景 Clinical studies have been inconclusive about the effectiveness of N95 respirators and medical m...

ICU Management & Practice, Volume 19 - Issue 2, 2019 Use of sedation and controlled paralysis in ICU patients with ARDS According to a National Institutes of Health sponsored clinical trial that was conducted at several North American hospitals and was led by clinician-scientists at the University of Pittsburgh and University of Colorado schools of medicine, reversibly paralysing and sedating hospitalised patients with severe breathing problems does not pro...

Original Investigation August 27, 2019 Association Between Educational Attainment and Causes of Death Among White and Black US Adults, 2010-2017 Isaac Sasson, Mark D. Hayward JAMA. 2019;322(8):756-763. doi:10.1001/jama.2019.11330 Abstract Importance 背景 There are substantial and increasing educational differences in US adult life expectancy. To reduce social inequalities in mortality, it is important to understand...

ARTICLES| VOLUME 7, ISSUE 8, P699-709, AUGUST 01, 2019 Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial Pradeesh Sivapalan, Therese S Lapperre, Julie Janner, et al. Lancet Respir Med 2019; 7: 699-709 DOI:https://doi.org/10.1016/S2213-2600(19)30176-6 Summary Background 背景 Treatment with systemic corticost...

ICU Management & Practice, Volume 18 - Issue 3, 2018 Fluids in shock Fluid management during shock from physiology to bedside. Shock is a common life-threatening, generalised form of acute circulatory failure in critically ill patients, which is usually managed by infusing fluids to increase cardiac output and supply the systemic oxygen request. International guidelines recommend use of an aggressive fluid resuscitation in the early phases of shock. In t...