Preliminary Communication Caring for the Critically Ill PatientOctober 1, 2019 Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial Alpha A. Fowler III, Jonathon D. Truwit, R. Duncan Hite, et al JAMA. 2019;322(13):1261-1270. doi:10.1001/jama.2019.11825 Importanc...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016 Charles L. Sprung, Bara Ricou, Christiane S. Hartog, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14608 Importance 背景 End-of-life decisions occur daily in intensive care units (ICUs) around the world, and these practices ...

#LIVES2019: Are Printed Journals Obsolete? In an interesting session today @ESICM #LIVES2019 in Berlin, Dr. Adrian Wong, Consultant, Intensive Care Medicine and Anaesthesia, Royal Surrey County Hospital, UK, presented his views about printed journals and their purpose in the digital age. Dr. Wong began with a short history of the first scientific journal devoted to science which was published in 1665 - The Philosophical Transaction of the Royal Society. The full...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial Arnaud W. Thille, Grégoire Muller, Arnaud Gacouin, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14901 Importanc...

#LIVES2019: Findings from the DIANA Study Liesbet De Bus of Ghent University Hospital, Belgium, presented the findings of the DetermInants of Antimicrobial use aNd de-escalAtion (DIANA) study @ESICM #LIVES2019 in Berlin. Dr. De Bus started off by explaining the concept of de-escalation and how it is all about finding a balance between early adequate antimicrobial therapy on the one hand and reducing unnecessary exposure to antimicrobials on the other hand, mainl...

Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial Pierre-Francois Laterre, Scott M. Berry, Allan Blemings, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14607 Importance 背景 Norepinephrine, the first-line vasopr...

#LIVES2019: Findings from the NONSEDA Study Palle Toft of Odense University Hospital presented the findings of the “No sedation compared to sedation with a daily wake-up trial. A prospective randomized multicentre study - The NONSEDA-study” @ESICM in Berlin. The NON-SEDA study is a Scandinavian multicentre study conducted in Denmark, Norway, and Sweden that compared non-sedation with light sedation or arousable sedation. Only 8 intensive care units were included, b...

ARTICLES|ONLINE FIRST Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation Conor L Mallucci, Michael D Jenkinson, Elizabeth J Conroy, et al Lancet Published:September 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31603-4 Summary Background 背景 Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest neurosurgical procedures world...

#LIVES2019: Highlights from the Opening Ceremony @ESICM The 32nd Annual Congress of ESICM officially opened today at the CityCube in Berlin. At the #LIVES2019 opening ceremony, Jozef Kesecioglu, ESICM President, welcomed all participants. Prof. Kesecioglu offered his thanks to the ESICM team, office members and the executive committee members for their efforts during the last twelve months. He then talked about the creation of a new section in the society – The ...

Editorial August 27, 2019 Reporting and Interpretation of Randomized Clinical Trials Howard Bauchner, Robert M. Golub, Phil B. Fontanarosa JAMA. 2019;322(8):732-735. doi:10.1001/jama.2019.12056 High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence pyramid, either as stand-alone studies or as part of meta-analyses. However, the interpretation of an RCT is often complicated and involves an understanding of the ...