ORIGINAL ARTICLE Ambient Particulate Air Pollution and Daily Mortality in 652 Cities Cong Liu, Renjie Chen, Francesco Sera, et al Abstract BACKGROUND 背景 The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. 由于模型特征的差异以及发表偏倚，系统评估大气污染的时间序列研究受到挑战。 METHODS 方法学 We evaluated the associations of inhalable particulate...

ICU Management & Practice, Volume 18 - Issue 1, 2018 “Simulate, or not to simulate?” Evolution in medicine and the anaesthesia context.  A brief discussion about the importance and the state of the art of simulation in anaesthesia and intensive care medicine. Training in simulation plays a key role in complex systems such as aviation and the nuclear industry, to investigate predictable errors that lead to adverse outcomes. The advancement made by...

ORIGINAL ARTICLE Effects of Serelaxin in Patients with Acute Heart Failure Marco Metra, John R. Teerlink, Gad Cotter, et al N Engl J Med 2019; 381:716-726DOI: 10.1056/NEJMoa1801291 Abstract BACKGROUND 背景 Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that contributes to cardiovascular and renal adaptations during pregnancy. Previous studies have suggested that treatment with serelaxin may result in relief of symptoms and in b...

ORIGINAL ARTICLE Myocardial Viability and Long-Term Outcomes in Ischemic Cardiomyopathy Julio A. Panza, Alicia M. Ellis, Hussein R. Al-Khalidi, et al N Engl J Med 2019; 381:739-748DOI: 10.1056/NEJMoa1807365 Abstract BACKGROUND 背景 The role of assessment of myocardial viability in identifying patients with ischemic cardiomyopathy who might benefit from surgical revascularization remains controversial. Furthermore, although improvement in left ventricular...

Assessing delirium in the ICU Dr. Ulf Guenther from Germany made an excellent presentation today at Euroanaesthesia 2019 #EA19 on assessing delirium in the ICU. Dr. Guenther has spent a large part of his research career dealing with delirium, and he shared his insight with respect to the clinical impact, diagnosis, risk factors, and management of delirium in the ICU. According to Dr. Guenther, acute inattention is the core feature of delirium that clinicians mus...

ICU Management & Practice, Volume 19 - Issue 2, 2019 Infographic: Caring for the critically ill child

COMMENT|ONLINE FIRST Uncovering covert stroke in surgical patients Phillip E Vlisides, Michael S Avidan, George A Mashour Lancet epub August 15, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31770-2 Stroke can be a devastating complication of surgery, with few effective strategies for detection or prevention. Overt stroke (ie, stroke with clinically apparent manifestations) occurs in approximately 0·1–1·0% of patients undergoing non-cardiac surgery and is ass...

ICU Management & Practice, Volume 19 - Issue 1, 2019 Extravascular lung water as a target for intensive care The paper highlights the present clinical rationale for extravascular lung water measurement as a key to personalisation of haemodynamic therapy. Introduction Extravascular lung water (EVLW) remains a useful guide for monitoring pulmonary oedema (PO) and vascular permeability in sepsis, acute respiratory distress syndrome (ARDS), and ...

ARTICLES|ONLINE FIRST Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial Laura Koskenvuo, Taru Lehtonen, Selja Koskensalo, et al Lancet epub August 08, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31269-3 Summary Background 背景 Decreased surgical site infections (SSIs) and morbidity have been reported with mechanical and oral antibiotic...

ICU Management & Practice, Volume 18 - Issue 4, 2018 How to manage severe dengue infection A review of diagnosis and treatment of dengue, a mosquito-borne febrile illness caused by flavivirus with a clinical spectrum ranging from self-limited fever to dengue haemorrhagic fever with shock.  Dengue is a febrile illness, caused by one of the serotypes of Flavivirus (DENV1-4), transmitted by Aedes aegypti and Aedes albopictus mosquitoes during a blood m...