Research Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study BMJ 2019; 365: l1580 https://doi.org/10.1136/bmj.l1580 Abstract Objective 目的 To estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs). 估算服用质子泵抑制剂(PPI)患者的全因病死率及疾病特异性病死率。 Design 试验设计 Longitudinal o...

Research Intensive care use and mortality among patients with ST elevation myocardial infarction: retrospective cohort study BMJ 2019; 365: l1927 https://doi.org/10.1136/bmj.l1927 Cite this as: BMJ 2019;365:l1927 Abstract Objective 目的 To evaluate the effect of intensive care unit (ICU) admission on mortality among patients with ST elevation myocardial infarction (STEMI). 评价收治ICU对STEMI患者病死率的影响 Design 试验...

Editorial June 3, 2019 Setting Positive End-Expiratory Pressure in Mechanically Ventilated Patients Undergoing Surgery Thomas Godet, Emmanuel Futier JAMA. 2019;321(23):2285-2287. doi:10.1001/jama.2019.7540 What is the optimal level of positive end-expiratory pressure (PEEP) for patients receiving mechanical ventilation? Despite decades of investigations, this question continues to be discussed among researchers and clinicians with no clear answer, leaving...

Reasonable Doubt Don't Be Fooled by New Study Tamiflu Still Pretty Worthless for H1N1 Runde, Dan, MD Emergency Medicine News: April 2019 - Volume 41 - Issue 4 - p 6 doi: 10.1097/01.EEM.0000554842.09002.7c It's possible that the Tamiflu pandemonium may be peaking for most emergency and primary care physicians because the dubious benefits of oseltamivir have now been well documented, discussed, and disseminated. (See box.) But there's also a new kid on the...

Original Investigation Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology JAMA. 2019;321(23):2292-2305. doi:10.1001/jama.2019.7505 Abstract ...

Editorial June 11, 2019 Revisiting, Reframing, and Casting a New Light on Liberation From Mechanical Ventilation Timothy D. Girard, Karen E. A. Burns JAMA. 2019;321(22):2167-2169. doi:10.1001/jama.2019.7364 Every year, more than 1 million patients throughout the world receive mechanical ventilation for acute respiratory failure. One of the most important decisions clinicians make in managing these critically ill patients is how to liberate them ...

Fluid responsiveness in sepsis: the fluid challenge revisiting (FCREV) study Fluid challenge is a common practice in the ICU. It is one of the most important resuscitation manoeuvres of acute circulatory failure management in critically ill patients. Adequate fluid resuscitation is very important because both hypovolaemia and fluid overload can result in poor outcomes in the ICU. The criteria for fluid administration still remains controversial. A study was cond...

ORIGINAL ARTICLE Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis Michael R. Wilson, Hannah A. Sample, Kelsey C. Zorn, et al N Engl J Med 2019; 380:2327-2340DOI: 10.1056/NEJMoa1803396  Abstract BACKGROUND 背景 Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF) has the potential to identify a broad range of pathogens in a single test. 脑脊液(CSF)的宏基因二代测序(NGS)能够通过一次检测鉴别多种致病微...

Original Investigation June 11, 2019 Association of Blood Donor Sex and Prior Pregnancy With Mortality Among Red Blood Cell Transfusion Recipients Gustaf Edgren Edward L. Murphy, Don J. Brambilla, et al JAMA. 2019;321(22):2183-2192. doi:10.1001/jama.2019.7084 Abstract 摘要 Importance 背景 Evidence regarding associations of blood donor sex with mortality among red blood cell transfusion recipients is conflicting. 有关献血者性别与接受输血...

Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial Donat R Spahn, Felix Schoenrath, Gabriela H Spahn, et al Lancet 2019; 393: 2201-2212 DOI:https://doi.org/10.1016/S0140-6736(18)32555-8 Summary Background 背景 Anaemia and iron deficiency are frequent in patients scheduled for cardiac surgery. This study assessed whether immediate preoperative treatment could result...