Articles Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jiroveciipneumonia (PIC): a multicentre, double-blind, randomised controlled trial Virginie Lemiale, Matthieu Resche-Rigon, Yoann Zerbib, et al Lancet Respir Med 2025; 13: 800-808 https://doi.org/10.1016/S2213-2600(25)00125-0 Summary Background Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised patients has a hospital mortality rate of 30–5...

ORIGINAL ARTICLE High-Dose Influenza Vaccine to Reduce Hospitalizations Jacobo Pardo-Seco, Carmen Rodríguez-Tenreiro-Sánchez, Iago Giné-Vázquez, et al N Engl J Med Published August 30, 2025 DOI: 10.1056/NEJMoa2509834 Abstract BACKGROUND Superior protection against laboratory-confirmed influenza has been proved for high-dose inactivated influenza vaccine, as compared with the standard dose, among adults 65 years of age or older. However, data on the re...

Electronic Sepsis Screening and Mortality  In Sepsis Wed, 12 Mar 2025 Early recognition and treatment of sepsis are crucial for improving patient outcomes, leading to clinical guidelines recommending sepsis screening programmes. However, evidence supporting these programmes is limited. Observational studies suggest screening improves care processes, such as timely lactate measurement and antibiotic administration, and may reduce mortality. However...

ORIGINAL ARTICLE High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults Niklas Dyrby Johansen, Daniel Modin, Matthew M. Loiacono, et al N Engl J Med Published August 30, 2025 DOI: 10.1056/NEJMoa2509907 Abstract BACKGROUND High-dose inactivated influenza vaccine has been shown to provide protection against influenza that is superior to that with the standard dose. However, data from individually randomized trials on the effec...

ORIGINAL ARTICLE Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias Christian Jøns, Chaoqun Zheng, Ulrik C.G. Winsløw, et al N Engl J Med Published August 29, 2025 DOI: 10.1056/NEJMoa2509542 Abstract BACKGROUND Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing plasma potassiu...

Articles Epidemiological and demographic trends and projections in global health from 1970 to 2050: a descriptive analysis from the third Lancet Commission on Investing in Health, Global Health 2050 Angela Y Chang, Sarah Bolongaita SM, Bochen Cao, et al Lancet 2025; 406: 940-949 https://doi.org/10.1016/S0140-6736(25)00902-X Summary Background Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We a...

Industry Payments and Prescription of Inhaled Medications In ICU Tue, 3 Jun 2025 The Physician Payments Sunshine Act mandates public disclosure of payments from pharmaceutical and medical device companies to clinicians. While previous research shows these payments can influence prescribing habits, less is known about their impact on drug-device combinations like inhalers. These products involve both medication and a delivery device, often requiring cli...

Original Investigation  Critical Care Medicine Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension Elizabeth S. Munroe, Ivan N. Co, Ivor Douglas, et al JAMA Netw Open 2025;8;(8):e2529148. doi:10.1001/jamanetworkopen.2025.29148 Key Points Question  How are peripheral vasopressors used in early sepsis resuscitation, and is their use safe? Findings  In this cohort study of 582 patients from the Crystalloid Liberal vs E...

Research Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial Hui Ye, Li-Hua Chu, Guo-Hao Xie, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-084539 (Published 19 August 2025)Cite this as: BMJ 2025;390:e084539 Abstract Objectives To evaluate the effect of lateral versus supine positioning on incidence of hypoxaemia in sedated patients and to provide evidence based recommendation...

CRITICAL CARE: ORIGINAL RESEARCH Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients: A Randomized Controlled Trial Andrew J. Franck, Andrew L. Hendrickson, Evan D. Telford, et al Chest 2025; 168: 326-335 Abstract Background Continuous glucose monitors (CGMs) could potentially improve management of hyperglycemia compared with standard point-of-care glucose monitoring for critically ill patients. However, there is limited evidence t...