Original Investigation April 6, 2020 Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella, et al JAMA. Published online April 6, 2020. doi:10.1001/jama.2020.5394 Abstract Importance In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread ...

Perspective Critical Supply Shortages — The Need for Ventilators and Personal Protective Equipment during the Covid-19 Pandemic Megan L. Ranney, Valerie Griffeth, Ashish K. Jha N Engl J Med 2020; 382:e41DOI: 10.1056/NEJMp2006141 On March 11, 2020, the World Health Organization designated “coronavirus disease 2019” (Covid-19) a global pandemic. As the number of cases in the United States continues to grow, political leaders are encouraging physical (or “social”...

Research Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal Laure Wynants, Ben Van Calster, Marc M J Bonten, et al BMJ 2020; 369:m1328 doi: https://doi.org/10.1136/bmj.m1328 Abstract Objective To review and critically appraise published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with ...

ARTICLES|ONLINE FIRST Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Yeming Wang, Dingyu Zhang, Guanhua Du, et al Lancet Published:April 29, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31022-9 Summary Background No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, ...

News Covid-19: What is the evidence for cloth masks? Elisabeth Mahase BMJ 2020;369:m1422 doi: https://doi.org/10.1136/bmj.m1422 As the US Centers for Disease Control and Prevention has advised all Americans to wear cloth masks in public to prevent the spread of covid-19, The BMJ examines the evidence What has the CDC recommended? People should wear cloth face coverings in public places where social distancing measures are “difficult to maintain...

张少雷译 感染控制: 对于在COVID-19患者身上进行有可能产生气溶胶操作的医护人员，COVID-19治疗指南小组(the Panel)建议使用合适的呼吸面罩(N-95呼吸面罩)或动力空气净化呼吸面罩，而不是外科口罩，此外还应使用其他个人防护装备，即手套、防护服及面屏、护目镜等护眼用具(AIII)。 建议对于COVID-19患者，如果可能，由具有丰富气道管理经验的医务人员进行气管内插管(AIII)。 建议如果可能的话，可以通过可视喉镜进行插管(CIII)。 血流动力学支持: 建议去甲肾上腺素作为首选的升压药物(AII)。 ...

Research Letter February 14, 2020 Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China Min Wei, Jingping Yuan, Yu Liu, et al JAMA. 2020;323(13):1313-1314. doi:10.1001/jama.2020.2131 Since December 8, 2019, an epidemic of coronavirus disease 2019 (COVID-19) has spread rapidly.1 As of February 6, 2020, China reported 31 211 confirmed cases of COVID-19 and 637 fatalities. Previous studies suggest that COVID-19 is more like...

ESPEN expert statements and practical guidance for nutritional management of individuals with sars-cov-2 infection. Clinical Nutrition , https://doi.org/10.1016/j.clnu.2020.03.022 新冠肺炎不良预后与高病死率与免疫功能低下、高龄、合并基础疾病、肥胖以及营养不良密切相关，炎症反应与并发的全身感染（sepsis）使病情进一步加重。 ICU住院时间延长本身就可导致病人获得性营养不良与严重的骨骼肌丧失。最近，ESPEN（European Society for Clinical Nutrition and Metabolism，）为COVID-...

Persons at Risk for Infection with SARS-CoV-2 Pre-Exposure Prophylaxis The COVID-19 Treatment Guidelines Panel (the Panel) does not recommend the use of any agents for SARS-CoV-2 pre-exposure prophylaxis (PrEP) outside the setting of a clinical trial(AIII). Post-Exposure Prophylaxis The Panel does not recommend the use of any agents for SARS-CoV-2 post-exposure prophylaxis (PEP) outside the setting of a clinical trial (AIII). Management of Persons...

COVID-19: The Surviving Sepsis Campaign Guidelines The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing rapidly spreading illness, and COVID-19 has now affected thousands of people around the world. Clinicians are in urgent need of guidance to deal with this crisis. A panel of 36 experts from 12 countries proposed 53 questions, reviewed literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ...