The Epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional Survey Xie Jianfeng, Wang Hongliang, Kang Yan, et al  Crit Care Med: December 5, 2019 doi: 10.1097/CCM.0000000000004155 Abstract Objectives: 目的 We performed a national cross-sectional survey to determine the epidemiologic characteristics of patients with sepsis in ICU in China. 通过进行全国性横断面调查，以明确中国ICU内脓毒症的流行病学特征。 Design: ...

Original Investigation January 21, 2020 Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial Emmanuel Futier, Matthias Garot, Thomas Godet, et al JAMA. 2020;323(3):225-236. doi:10.1001/jama.2019.20833 Importance  It is not known if use of colloid solu...

Practice | Rapid Recommendations Gastrointestinal bleeding prophylaxis for critically ill patients: a clinical practice guideline Zhikang Ye, Annika Reintam Blaser, Lyubov Lytvyn, et al BMJ 2020; 368:l6722 doi: https://doi.org/10.1136/bmj.l6722 Abstract Clinical question 临床问题 What is the role of gastrointestinal bleeding prophylaxis (stress ulcer prophylaxis) in critically ill patients? This guideline was prompted by the publication of a new large ra...

New Mode of Adaptive Ventilation For most patients who are admitted to the ICU and require mechanical ventilation, conventional modes of ventilation usually suffice. However, there are some patients who may require fine adjustments in ventilation so that the work of breathing is minimised, and the patient is still adequately ventilated and oxygenated. Over the years, many types of ventilatory approaches to protect the lung have been developed, but none has proven to...

Research Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis Ying Wang, Zhikang Ye, Long Ge, et al BMJ 2020; 368 doi: https://doi.org/10.1136/bmj.l6744 (Published 06 January 2020) Cite this as: BMJ 2020;368:l6744 Abstract Objective 背景 To determine, in critically ill patients, the relative impact of proton pump inhibitors (PPIs), histamine...

ICU Management & Practice, Volume 19 - Issue 3, 2019 Knowledge Transfer to Improve Outcomes in Critically Ill Immunocompromised Patients An overview on sharing information, improving clinician skills, and transferring knowledge to ICU specialists about the care of immunocompromised patients. Background Studies have reported a volume-outcome relationship for cancer patients admitted to the ICU. In acute respiratory failure, mortality in ICUs managing m...

Risk Factors for ARDS in Mechanically Ventilated Adults Acute respiratory distress syndrome (ARDS) is an inflammatory process that could lead to diffuse oedema and hypoxaemic respiratory failure. It is also characterised by increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung. In low and middle-income countries, ARDS mortality ranges from 26 to 58%.  A large majority of patients require mechanical ventilation with positive press...

Editorial | December 30, 2019 Decreasing Staphylococcus aureus in the Neonatal Intensive Care Unit by Decolonizing Parents Philip Zachariah, Lisa Saiman JAMA. Published online December 30, 2019. doi:https://doi.org/10.1001/jama.2019.20784 Infants hospitalized in the neonatal intensive care unit (NICU) continue to pose challenges for infection prevention and control.1 Immunologic immaturity in addition to iatrogenic risk factors, such as high rates of...

Hydrocortisone Versus Placebo in Patients with Septic Shock Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these studies have not shown any significant benefit. The few studies th...

Preliminary Communication | December 30, 2019 Effect of Treating Parents Colonized With Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit: A Randomized Clinical Trial Aaron M. Milstone, Annie Voskertchian, Danielle W. Koontz, et al JAMA. Published online December 30, 2019. doi:https://doi.org/10.1001/jama.2019.20785 Abstract Importance 背景 Staphylococcus aureus is a l...