Trauma Triage Model for Critical Care Transport In ICU Wed, 11 Jun 2025 Advancements in civilian casualty care can reduce mortality from trauma, particularly those due to airway compromise or prehospital haemorrhage. Timely delivery of lifesaving interventions (LSIs) is crucial but challenging for prehospital medics, who must make rapid decisions under constrained conditions with limited experience and unreliable triage guidelines. Machine learning ...

Critical Care: Original Research Low-Intensity vs Moderate-Intensity Anticoagulation for Venovenous Extracorporeal Membrane Oxygenation: The Strategies for Anticoagulation During Venovenous Extracorporeal Membrane Oxygenation Pilot Trial Whitney D. Gannon, Elias H. Pratt, Melissa A. Vogelsong, et al Chest 2025; 168: 639-649 https://doi.org/10.1016/j.chest.2025.02.032 Background Bleeding is a common and sometimes fatal complicatio...

Transfusion of Fresh Frozen Plasma and Platelets in Critically Ill Adults: An American College of Chest Physicians Clinical Practice Guideline Angel Coz Yataco, Israa Soghier, Paul C. Hébert, et al Chest 2025; 168: 661-676 DOI: 10.1016/j.chest.2025.02.029 Abstract Background Platelets and fresh frozen plasma (FFP) are frequently administered to critically ill patients. Considering the variability in indications and thresholds guiding these transfusions, ...

Original Investigation Nonregistration, Discontinuation, and Nonpublication of Randomized Trials: A Systematic Review Benjamin Speich, Ala Taji Heravi, Christof M. Schönenberger, et al JAMA Netw Open 2025;8;(9):e2524440. doi:10.1001/jamanetworkopen.2025.24440 Key Points Question  What percentage of randomized clinical trials (RCTs) are unregistered, prematurely discontinued, or unpublished? Findings  This systematic review assessing 3...

LLM Diagnostic Performance in Complex Critical Illness In ICU Wed, 11 Jun 2025 Large language models (LLMs) are increasingly used in healthcare for education, research, and clinical care. They have shown promise by passing all stages of the US Medical Licensing Exam and generating accurate, empathetic responses to patient queries, suggesting the potential to assist physicians in complex clinical decision-making, including differential diagnosis.  ...

Articles Profile of central line-associated bloodstream infections in adult, paediatric, and neonatal intensive care units of hospitals participating in a health-care-associated infection surveillance network in India: a 7-year multicentric study Rasna Parveen, Arpan Kumar Thakur, Sharad Srivastav, et al Lancet Global Health 2025; 13: e1564-e1573 https://doi.org/10.1016/S2214-109X(25)00221-9 Summary Background Central line-associated bloodstream infec...

Articles Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Infect Dis Available online 28 August 2025 https://doi.org/10.1016/S1473-3099(25)00361-5 Summary Background Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVE...

Comment Infections in long-term care: burden affirmed, action needed Philipp Kohler, Allison McGeer Lancet Infect Dis Available online 16 June 2025 https://doi.org/10.1016/S1473-3099(25)00287-7 In The Lancet Infectious Diseases, Enrico Ricchizzi and colleagues report the results of a year-long study of the incidence of health-care-associated infections (HAIs) in long-term care facilities (LTCFs) in nine European countries.1 Using prospective surve...

Atrial Fibrillation in Critical Illness In ICU Wed, 11 Jun 2025 Atrial fibrillation (AF) presents significant management challenges in the ICU. Pre-existing AF affects 10–20% of ICU patients, while new-onset AF (NOAF) occurs in 5–15% of critically ill individuals and up to 46% in those with septic shock. NOAF may be transient or indicate an underlying predisposition, complicating treatment decisions.  AF in critical illness is linked to worse o...

Articles Incidence of health-care-associated infections in long-term care facilities in nine European countries: a 12-month, prospective, longitudinal cohort study Enrico Ricchizzi, Elena Sasdelli, Anna Caterina Leucci, et al Lancet Infect Dis Available online 16 June 2025 https://doi.org/10.1016/S1473-3099(25)00217-8 Summary Background The number of older people in need of long-term care is increasing, and health-care-associated infections (HAIs) are...