Original Investigation Caring for the Critically Ill PatientOctober 2, 2019 Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial Pierre-Francois Laterre, Scott M. Berry, Allan Blemings, et al JAMA. Published online October 2, 2019. doi:10.1001/jama.2019.14607 Importance 背景 Norepinephrine, the first-line vasopr...

#LIVES2019: Findings from the NONSEDA Study Palle Toft of Odense University Hospital presented the findings of the “No sedation compared to sedation with a daily wake-up trial. A prospective randomized multicentre study - The NONSEDA-study” @ESICM in Berlin. The NON-SEDA study is a Scandinavian multicentre study conducted in Denmark, Norway, and Sweden that compared non-sedation with light sedation or arousable sedation. Only 8 intensive care units were included, b...

ARTICLES|ONLINE FIRST Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation Conor L Mallucci, Michael D Jenkinson, Elizabeth J Conroy, et al Lancet Published:September 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)31603-4 Summary Background 背景 Insertion of a ventriculoperitoneal shunt for hydrocephalus is one of the commonest neurosurgical procedures world...

#LIVES2019: Highlights from the Opening Ceremony @ESICM The 32nd Annual Congress of ESICM officially opened today at the CityCube in Berlin. At the #LIVES2019 opening ceremony, Jozef Kesecioglu, ESICM President, welcomed all participants. Prof. Kesecioglu offered his thanks to the ESICM team, office members and the executive committee members for their efforts during the last twelve months. He then talked about the creation of a new section in the society – The ...

Editorial August 27, 2019 Reporting and Interpretation of Randomized Clinical Trials Howard Bauchner, Robert M. Golub, Phil B. Fontanarosa JAMA. 2019;322(8):732-735. doi:10.1001/jama.2019.12056 High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence pyramid, either as stand-alone studies or as part of meta-analyses. However, the interpretation of an RCT is often complicated and involves an understanding of the ...

Extracorporeal Life Support for Patients with Acute Respiratory Failure Millions of people with acute respiratory failure are hospitalised every year. Nearly half of these patients require invasive mechanical ventilation. In-hospital mortality in these patients is quite high. Despite the fact that mechanical ventilation is the primary management tool for such patients, it is associated with major complications that increase mortality. That is why there is a need fo...

Research Letter September 3, 2019 Incidence of Maternal Sepsis and Sepsis-Related Maternal Deaths in the United States Matthew K. Hensley, Melissa E. Bauer, Lindsay K. Admon, et al. JAMA. 2019;322(9):890-892. doi:10.1001/jama.2019.9818 Results From 63 665 593 hospitalizations in the NRD (2013-2016), there were 5 957 678 delivery hospitalizations with discharges in January through October, of which 32.5% were...

Personalised Mechanical Ventilation - The LIVE Study The effectiveness of personalised mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) is still unclear. A new study was conducted in France to test whether a mechanical ventilation strategy personalised to an individual patient's lung morphology could improve survival compared with the standard of care. For the purpose of this study, 400 patients with moderate-to-severe ARDS were...

PERSONAL VIEW|ONLINE FIRST Improving the estimation of the global burden of antimicrobial resistant infections Direk Limmathurotsakul, Susanna Dunachie, Keiji Fukuda, et al. Lancet Infect Dis Published:August 16, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30276-2 Summary Estimating the global burden of disease from infections caused by pathogens that have acquired antimicrobial resistance (AMR) is essential for resource allocation and to inform AMR acti...

Global Survey of Management of Severe Paediatric Traumatic Brain Injury (TBI) in LMIC 近期，Pediatr Crit Care Med发表了有关严重颅脑外伤患儿诊疗的2019年国际共识(Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies)。为了解中低收入国家严重颅脑外伤患儿诊疗现状，来自加拿大温哥华的研究者进行了一项问卷调查，以期为今后的科研工作、指南制定提供更多依据。 支持组织：世界儿童重症医学联盟(World F...