ARTICLES|ONLINE FIRST Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial Christopher C Butler, Alike W van der Velden, Emily Bongard, et al Lancet Published: December 12, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)32982-4 Background 背景 Antivirals are infrequently prescribed in European primary care for influenza-like illness, mostly because of perceived ineffe...

Anti-influenza Hyperimmune Intravenous Immunoglobulin for Adults With Influenza A or B Infection (FLU-IVIG): A Double-Blind, Randomised, Placebo-Controlled Trial Richard T Davey Jr, Eduardo Fernández-Cruz, Norman Markowitz, et al Lancet Respir Med 2019; 7: 951-963 Background 背景 Since the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (h...

CorrespondenceSepsis hysteria: excess hype and unrealistic expectations MervynSinger, Matt Inada-Kim, ManuShankar-Hari Lancet 2019; 394: 1513-1514 “Sepsis kills over 52 000 every year—each death a preventable tragedy”, tweeted Matt Hancock, UK Secretary of State for Health and Social Care, in March, 2019.1 Many other non-contextualised or fictitious claims regularly fill media pages and airwaves, creating a distorted picture of sepsis epidemiology and unreal...

Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial Michael Mullen, Xu Yu Jin, Anne Child, et al Lancet Published: December 10, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)32518-8 Background 背景 Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We aimed to determine the effects of irbesartan on t...

ORIGINAL ARTICLE FREE PREVIEW Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network N Engl J Med December 11, 2019DOI: 10.1056/NEJMoa1911124 Abstract BACKGROUND 背景 Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. The potential benefits of vitamin D supplementation in acute c...

ORIGINAL ARTICLE FREE PREVIEW Metoprolol for the Prevention of Acute Exacerbations of COPD Mark T. Dransfield, Helen Voelker, Surya P. Bhatt, et al N Engl J Med 2019; 381:2304-2314DOI: 10.1056/NEJMoa1908142 BACKGROUND 背景 Observational studies suggest that beta-blockers may reduce the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but these findings have not been confirmed in randomized tri...

Anti-influenza Immune Plasma for the Treatment of Patients With Severe Influenza A: A Randomised, Double-Blind, Phase 3 Trial John H Beigel, Evgenia Aga, Marie-Carmelle Elie-Turenne, et al Lancet Respir Med 2019; 7: 941-950 Background 背景 Infection with influenza virus causes substantial morbidity and mortality globally, although antiviral treatments are available. Previous studies have suggested that anti-influenza immune plasma could be beneficial...

ICU Management & Practice, Volume 19 - Issue 3, 2019 Virtual Reality in the Intensive Care Unit: State of Play and Future Prospects An overview of the practical uses of virtual reality in the ICU and the benefits it can provide. One way of defining virtual reality (VR) is as the set of techniques and systems required for human beings to enter computer-generated synthetic worlds. VR techniques are based on real-time interaction with an artificial immersiv...

Original Investigation November 5, 2019 Effect of Caspofungin vs Fluconazole Prophylaxis on Invasive Fungal Disease Among Children and Young Adults With Acute Myeloid Leukemia: A Randomized Clinical Trial Brian T. Fisher, Theoklis Zaoutis, Christopher C. Dvorak, et al JAMA. 2019;322(17):1673-1681. doi:10.1001/jama.2019.15702 Importance 背景 Children, adolescents, and young adults with acute myeloid leukemia ...

Original Investigation December 10, 2019 Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial Philip C. Spinella, Marisa Tucci, Dean A. Fergusson, et al JAMA. 2019;322(22):2179-2190. doi:10.1001/jama.2019.17478 Importance 背景 The clinical consequences of red blood cell storage age for criti...