Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study Summary Background 背景 Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the global burden of sepsis are limited. As a syndrome caused by underlying infection, sepsis is not part of standard Global Burden of Diseases, Injuries, and Risk Fa...

SPOTLIGHT|ONLINE FIRST Organising international research in critical care medicine: current challenges and potential solutions Jan J De Waele, Dylan W de Lange Lancet Respir Med Published: December 17, 2019 DOI:https://doi.org/10.1016/S2213-2600(19)30475-8 During the first years of intensive care medicine, many of its treatments were introduced because they were thought to be beneficial to patients, despite there being a lack of evidence from high-quality rese...

ICU Management & Practice, Volume 19 - Issue 3, 2019 The Metabolic Phenotype of Skeletal Muscle During Early Critical Illness The Muscle UK Critical Care program was set up 10 years ago and focused on the association between muscle and skeletal muscle wasting to weakness to clinical outcome. There are a total of five pivotal trials, including Bernhard Jonghe et al.1 and Herridge M.2 that looked at skeletal muscle weakness and its impact on patients. In the ...

Research Christmas 2019: Let it Be Q fever—the superstition of avoiding the word “quiet” as a coping mechanism: randomised controlled non-inferiority trial Charlotte R Brookfield, Patrick P J Phillips, Robert J Shorten BMJ 2019; 367: l6446 doi: https://doi.org/10.1136/bmj.l6446 (Published 18 December 2019) Objective 目的 To determine the validity of the superstition that utterance of the word “quiet” in a clinical setting increases workload. 确定在...

Research Christmas 2019: Sweet Little Lies The SSSPIN study—spin in studies of spin: meta-research analysis Lisa Bero, Kellia Chiu, Quinn Grundy BMJ 2019; 367: l6202 doi: https://doi.org/10.1136/bmj.l6202 (Published 18 December 2019) Objectives 目的 To identify and calculate the prevalence of spin in studies of spin. 确定并计算有关倾向性陈述研究中倾向性陈述的比例 Design 试验设计 Meta-research analysis (research on research). meta研究分析(对...

ICU Management & Practice, Volume 19 - Issue 3, 2019 DIVINE Nutritional Management in ICU The following is an overview of the DIVINE trial (Dietary Management of Glucose Variabilty in the ICU) as well as a quick summary of the role of glucose control and outcomes in critically ill patients. The DIVINE study was funded by Nestlé. Clinical studies show that goal nutrition may not result in the best outcomes. Available data suggest that protein may be more ...

Research Christmas 2019: Shiny Happy People Bend it like Beckham or fix them like Florence—proportional representation of healthcare in New Year honours: an observational study John A Emelifeonwu, James E Hazelwood, Oscar Nolan, et al BMJ 2019;367:l6721 doi: https://doi.org/10.1136/bmj.l6721 (Published 18 December 2019)  Objectives 目的 To compare the proportional representation of healthcare workers in receipt of New Year honours (NYHs) with workers i...

Research Christmas 2019: Sweet Little Lies Gender differences in how scientists present the importance of their research: observational study Marc J Lerchenmueller, Olav Sorenson, Anupam B Jena BMJ 2019; 367: l6573 doi: https://doi.org/10.1136/bmj.l6573 (Published 16 December 2019) Abstract Objectives 目的 Women remain underrepresented on faculties of medicine and the life sciences more broadly. Whether gender differences in self presentation of cli...

ARTICLES| VOLUME 394, ISSUE 10216, P2255-2262, DECEMBER 21, 2019 Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study Takahiro Nakashima, Teruo Noguchi, Yoshio Tahara, et al Lancet 2019; 394: 2255-2262 Background 背景 More than 80% of public-access defibrillation attempts do not result in sustained return of spontaneous circulation in patients who have...

Research Christmas 2019: Chasing Cars Physical activity and weight following car ownership in Beijing, China: quasi-experimental cross sectional study Michael L Anderson, Fangwen Lu, Jun Yang BMJ 2019;367:l6491 doi: https://doi.org/10.1136/bmj.l6491 (Published 18 December 2019) Objective 目的 To determine the implications of car ownership for physical activity and weight in a global city. 确定全球性城市中买车对于体力活动及体重的影响。 Design 试验...