April 14, 2020 Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial Nina Singh, Drew J. Winston, Raymund R. Razonable, et al. JAMA. 2020;323(14):1378-1387. doi:10.1001/jama.2020.3138 Abstract Importance Despite the use of a cytomegalovirus (CMV) prevention strategy of antiviral prophylaxis for high-risk CMV-seronegative ...

Practice Practice Pointer Interpreting a covid-19 test result Jessica Watson, Penny F Whiting, John E Brush BMJ 2020; 369: m1808 doi: https://doi.org/10.1136/bmj.m1808 (Published 12 May 2020) What you need to know Interpreting the result of a test for covid-19 depends on two things: the accuracy of the test, and the pre-test probability or estimated risk of disease before testingA positive RT-PCR test for covid-19 test has more weight than a negative t...

Viewpoint April 6, 2020 The COVID-19 Pandemic in the USA: Clinical Update Saad B. Omer, Preeti Malani, Carlos del Rio JAMA. 2020;323(18):1767-1768. doi:10.1001/jama.2020.5788 Since the first US case of coronavirus disease 2019 (COVID-19) infection as identified in Washington State on January 20, 2020, more than 235 000 cases have been identified across the US in just over 2 months. Given the challenges in expanding testing capacity and the restrictive cas...

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials Lancet 2020; 395: 1506-1515 Summary Background The timing of renal replacement therapy (RRT) for severe acute kidney injury is highly debated when no life-threatening complications are present. We assessed whether a strategy of delayed versus early RRT initiation affects 28-day ...

CORRESPONDENCE Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy N Engl J Med April 29, 2020DOI: 10.1056/NEJMc2010418 TO THE EDITOR: Despite the risk of rapid respiratory failure1 and cardiac complications2 due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas to have an outbreak of Covid-19 outside China,3 and ...

Original Investigation May 11, 2020 Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Eli S. Rosenberg, PElizabeth M. Dufort, Tomoko Udo, et al JAMA. Published online May 11, 2020. doi:10.1001/jama.2020.8630 Abstract Importance Hydroxychloroquine, with or without azithromycin, has been considered as a possible therapeutic agent for patients with coronavir...

ORIGINAL ARTICLE Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Joshua Geleris, Yifei Sun, Jonathan Platt, et al N Engl J Med May 7, 2020DOI: 10.1056/NEJMoa2012410 Abstract BACKGROUND Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use. METHODS We examined the association between hydroxychloroquine use and intubation or death at a large medical center...

ARTICLES|ONLINE FIRST Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, et al Lancet Rheumatol Published:May 07, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30127-2 Summary Background Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARD...

ARTICLES|ONLINE FIRST Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial Ivan Fan-Ngai Hung, Kwok-Cheung Lung, Eugene Yuk-Keung Tso, et al Lancet Published:May 08, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31042-4 Summary Background Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVI...

JAMA Insights Clinical UpdateMarch 11, 2020 Care for Critically Ill Patients With COVID-19 Srinivas Murthy, Charles D. Gomersall, Robert A. Fowler JAMA. 2020;323(15):1499-1500. doi:10.1001/jama.2020.3633 Initial reports suggest that COVID-19 is associated with severe disease that requires intensive care in approximately 5% of proven infections.1 Given how common the disease is becoming, as in prior major severe acute respiratory infection outbreaks—S...