Research Christmas 2019: Chasing Cars Physical activity and weight following car ownership in Beijing, China: quasi-experimental cross sectional study Michael L Anderson, Fangwen Lu, Jun Yang BMJ 2019;367:l6491 doi: https://doi.org/10.1136/bmj.l6491 (Published 18 December 2019) Objective 目的 To determine the implications of car ownership for physical activity and weight in a global city. 确定全球性城市中买车对于体力活动及体重的影响。 Design 试验...

Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial Michael S Niederman, Jeff Alder, Matteo Bassetti, et al Lancet Infect Dis December 19, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30574-2 Background 背景 Treatment of ventilated pneumonia is often unsuccessful, even when patients are trea...

Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation Thomas P Hellyer, Daniel F McAuley, Timothy S Walsh, et al Lancet Respir Med December 03, 2019 DOI:https://doi.org/10.1016/S2213-2600(19)30367-4 Background Ventilator-associated pneumonia is the most common intensive care unit (ICU)-acquired infection, yet accurate diagnosis remains difficult, leading to overuse...

Research Christmas 2019: Express Yourself The art of life and death: 14 year follow-up analyses of associations between arts engagement and mortality in the English Longitudinal Study of Ageing Daisy Fancourt, Andrew Steptoe BMJ 2019;367:l6377 doi: https://doi.org/10.1136/bmj.l6377 (Published 18 December 2019) Abstract Objective 目的 To explore associations between different frequencies of arts engagement and mortality over ...

Passive immunity for the treatment of influenza: quality not quantity Sanjat Kanjilal, Michael J Mina Lancet 2019; 7: 922-923 The use of convalescent plasma to treat influenza infection was first described during the 1918 influenza pandemic.1 The concept is based on the assumption that patients who have recovered from an infection did so partly because they had effective antibody responses against the virus. However, studies into the clinical benefit of ...

Research Christmas 2019: Shiny Happy People Working 9 to 5, not the way to make an academic living: observational analysis of manuscript and peer review submissions over time Adrian Barnett, Inger Mewburn, Sara Schroter BMJ 2019;367:l6460 doi: https://doi.org/10.1136/bmj.l6460 (Published 19 December 2019) Objective 目的 To determine whether researchers are submitting manuscripts and peer reviews to BMJ journals out of hours and whether this has changed...

Original Investigation December 17, 2019 Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial Nikola Kozhuharov, Assen Goudev, Dayana Flores, et al JAMA. 2019;322(23):2292-2302. doi:10.1001/jama.2019.18598 Importance 背景 Short-term infusions of single vasodilators...

Research Christmas 2019: Let it Be Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study Yin Zhang,  Elizabeth E Devore, Susanne Strohmaier, et al BMJ 2019;367:l6058 doi: https://doi.org/10.1136/bmj.l6058 (Published 18 December 2019) Abstract Objectives 目的 To evaluate the associations between birth month, birth season, and overall and cardiovascular disease mortality, and to examine the r...

Research |Christmas 2019: Shiny Happy People Political events and mood among young physicians: a prospective cohort study BMJ 2019; 367: l6322 doi: https://doi.org/10.1136/bmj.l6322

Original Investigation December 17, 2019 Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence IntubationA Randomized Clinical Trial Bertrand Guihard, Charlotte Chollet-Xémard, Philippe Lakhnati, et al JAMA. 2019;322(23):2303-2312. doi:10.1001/jama.2019.18254 Importance 背景 Rocuronium and succinylcholine are often used for ra...