ORIGINAL ARTICLE Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 Jason D. Goldman, David C.B. Lye, David S. Hui, et al N Engl J Med May 27, 2020DOI: 10.1056/NEJMoa2015301 Abstract BACKGROUND Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19). METHODS We conducted a randomized, open-label, phase 3 trial involving hospitalized patients wit...

EDITORIAL Inhibitors of the Renin–Angiotensin–Aldosterone System and Covid-19 John A. Jarcho, Julie R. Ingelfinger, Mary Beth Hamel, et al N Engl J Med May 1, 2020DOI: 10.1056/NEJMe2012924 SARS-CoV-2, the coronavirus that causes Covid-19, enters human cells by binding of its viral spike protein to the membrane-bound form of the aminopeptidase angiotensin-converting enzyme 2 (ACE2).1 From the viewpoint of human physiology, ACE2 plays an important regulator...

Research Letter April 27, 2020 Exposure to a Surrogate Measure of Contamination From Simulated Patients by Emergency Department Personnel Wearing Personal Protective Equipment Oren Feldman, Michal Meir, Danielle Shavit, et al JAMA. 2020;323(20):2091-2093. doi:10.1001/jama.2020.6633 A major challenge with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is the effective protection of health care workers.1 Recommendations for t...

ARTICLES|ONLINE FIRST Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial Feng-Cai Zhu, Yu-Hua Li, Xu-Hua Guan, et al Lancet Published:May 22, 2020 DOI: https://doi.org/10.1016/S0140-6736(20)31208-3 Summary Background A vaccine to protect against COVID-19 is urgently needed. We aimed to assess the safety, tolerability, and immunogenicity...

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis Mandeep R Mehra, Sapan S Desai, Frank Ruschitzka, et al Lancet Published Online May 22, 2020 https://doi.org/10.1016/S0140-6736(20)31180-6 Summary Background Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their...

ORIGINAL ARTICLE Remdesivir for the Treatment of Covid-19 — Preliminary Report John H. Beigel, Kay M. Tomashek, Lori E. Dodd, et al N Engl J Med May 22, 2020DOI: 10.1056/NEJMoa2007764 Abstract BACKGROUND Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), none have yet been shown to be efficacious. METHODS We conducted a double-blind, randomized, placebo-controlled trial of intravenous r...

COVID-19 Pandemic: The Ethical Dilemma of Allocating Scarce Resources Coronavirus pandemic continues to intensify as does the shortage of ventilators and beds. In countries where cases are multiplying at a tremendous rate, a critical question that is being asked is: what criteria should be used to guide rationing decisions? What should be done when demand for ventilators and other intensive treatment exceeds the supply? A new viewpoint addresses these concerns and...

CORRESPONDENCE Covid-19 and Kidney Transplantation NEJM April 24, 2020DOI: 10.1056/NEJMc2011117 TO THE EDITOR: Kidney-transplant recipients appear to be at particularly high risk for critical Covid-19 illness due to chronic immunosuppression and coexisting conditions.1 At Montefiore Medical Center, we identified 36 consecutive adult kidney-transplant recipients who tested positive for Covid-19 between March 16 and April 1, 2020. A total of 26 recipients (...

Research Letter May 15, 2020 Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure Xavier Elharrar, Youssef Trigui, Anne-Marie Dols, et al JAMA. Published online May 15, 2020. doi:10.1001/jama.2020.8255 Patients with coronavirus disease 2019 (COVID-19) are at risk for acute respiratory distress syndrome.1 In intubated patients with severe acute respiratory distress syndrome, early and prolonged (...