ARTICLES|ONLINE FIRST Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial Yasuyuki Kakihana, Osamu Nishida, Takumi Taniguchi, et al. Lancet Respir Med Published:March 31, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30037-0 Summary Background Tachycardia and atrial fibrillation frequently occur in patients bei...

ICU Management & Practice, Volume 20 - Issue 1, 2020 Tracheal Intubation in the ICU Making tracheal intubation safe for both patients and their health care providers. Introduction COVID-19 is a newly recognised viral infection which first appeared in Wuhan, China in late 2019. It is caused by a novel Coronavirus, Severe Acute Respiratory Syndrome-CoronaVirus-2. For the most part it results in a mild, self-limiting flu-like illness but unfortunately, s...

Research Letter May 21, 2020 Postmortem Examination of Patients With COVID-19 Tina Schaller, Klaus Hirschbühl, Katrin Burkhardt, et al JAMA. 2020;323(24):2518-2520. doi:10.1001/jama.2020.8907 Approximately 15% of individuals affected by coronavirus disease 2019 (COVID-19) develop severe disease, and 5% to 6% are critically ill (respiratory failure and/or multiple organ dysfunction or failure).1,2 Severely ill and critically ill patients have a high mortal...

COVID-19: Universal Masking in Hospitals The SARS-Cov-2 pandemic has all healthcare institutions scrambling for protocols to prevent virus transmission. The name of the game is to protect both patients and healthcare providers from the virus. However, every hospital has its protocol with respect to precautionary measures that have been undertaken to prevent transmission. While some hospitals advocate universal masking, other institutions are more selective and only enc...

Mechanical Ventilation in COVID-19 There is no specific treatment for COVID-19 patients. For those who develop respiratory failure and are unable to oxygenate with non-invasive methods, critical care doctors are providing supportive therapy. Since the pandemic started, mechanical ventilation has routinely been employed to oxygenate seriously ill COVID-19 patients. Each hospital has developed its own criteria for identifying patients who require mechanical ven...

Original Investigation June 23/30, 2020 Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery: The DECISION Randomized Clinical Trial Vladimir Lomivorotov, Igor Kornilov, Vladimir Boboshko, et al JAMA. 2020;323(24):2485-2492. doi:10.1001/jama.2020.8133 Abstract Importance Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to...

Research Letter June 15, 2020 Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Staff in a Tertiary Center in Belgium Deborah Steensels, Els Oris, Laura Coninx, et al JAMA. Published online June 15, 2020. doi:10.1001/jama.2020.11160 Belgium has a high burden of coronavirus disease 2019 (COVID-19), especially the region surrounding the Hospital East-Limburg, a tertiary care center.1 Infection prevention measures were instituted in the hospital ...

ARTICLES|ONLINE FIRST GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study Giacomo De Luca, Giulio Cavalli, Corrado Campochiaro, et al Lancet Rheumatol Published:June 16, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30170-3 Summary Background Mortality in patients with COVID-19 pneumonia and systemic hyperinflammation is high. We aimed to examine whether mavrilimumab, a...

Research Letter | April 22, 2020 Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection Giacomo Spinato, Cristoforo Fabbris,  Jerry Polesel, et al JAMA. 2020;323(20):2089-2090. doi:10.1001/jama.2020.6771 Since December 2019, a pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally.1 A spectrum of disease severity has been reported, with m...

Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report RECOVERY Collaborative Group ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform ...