Research: Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice 引用格式：Feng Y, Huang Y, Wang Y, Wang P, Wang F. Severe burn injury alters intestinal microbiota composition and impairs intestinal barrier in mice. Burns Trauma. 2019;7:20. 严重烧伤后应激反应所释放的神经内分泌介质、缺血缺氧性损害、活化补体、氧自由基、炎症介质、细胞因子等都可直接或间接地参与肠道屏障功能损害的发生与发展。肠道屏障功能损害一方面可以引起肠道自...

#CoronavirusOutbreak: Caring for the Critically Ill - Trends, Treatment and Mortality COVID-19 is associated with severe disease requiring intensive care in approximately 5% of proven infections. As with similar outbreaks in the past, including SARS, MERS, A(H7N9), and H1N1, critical care continues to be an integral component of the global response to Coronavirus. You might also like: Coronavirus and the Potential Role of ECMO Antiviral and/or immunomodulatory th...

Research Article: Prediction of median survival time in sepsis patients by the SOFA score combined with different predictors 引用格式: Li W, Wang M, Zhu B, Zhu Y, Xi X. Prediction of median survival time in sepsis patients by the SOFA score combined with different predictors. Burns Trauma. 2020, tkz006. 脓毒症和脓毒性休克是当今重症患者最具威胁性的疾病之一，具有较高的发病率和病死率。本研究旨在确定序贯器官衰竭评分（SOFA）、急性生理与慢性健康评分II（APACHE II）、降钙素...

HealthManagement, Volume 20 - Issue 2, 2020 COVID-19: What Can Healthcare Learn? Summary: A new decade is normally a time for optimism and fresh starts but what 2020 ushered in was a new coronavirus. Named by WHO as COVID-19, the virus causes severe acute respiratory problems. It is thought to have emerged at a live animal market in the Chinese city of Wuhan at the end of 2019 with an initial trickle of reports soon turning into a deluge as it spread across bor...

Editorial March 24, 2020 Infection, Antibiotics, and Patient Outcomes in the Intensive Care Unit Mo Yin, Paul Anantharajah Tambyah, Eli N. Perencevich JAMA. Published online March 24, 2020. doi:10.1001/jama.2020.2241 Infection is a major cause of admissions and prolonged stays in intensive care units (ICUs). Epidemiological information on the underlying source of infections, associated microorganisms, treatment, and eventual outcomes is essentia...

COVID-19: How Can Hospitals Protect Workers and Patients? The novel coronavirus COVID-19 continues its spread globally. Public authorities are implementing various measures to contain or delay it, from complete or partial territorial lockdowns to closing schools to banning larger public gatherings. In this situation healthcare systems are on the front line, and hospitals and healthcare leadership must take necessary steps to ensure the safety of their staff, ...

Research Letter March 23, 2020 Ethics Committee Reviews of Applications for Research Studies at 1 Hospital in China During the 2019 Novel Coronavirus Epidemic Hui Zhang, Fengmin Shao, Jianqin Gu, et al JAMA. Published online March 23, 2020. doi:10.1001/jama.2020.4362 Since December 2019, an epidemic of coronavirus disease 2019 (COVID-19) has spread rapidly from Wuhan, Hubei Province, China.1 As of March 7, there were 1272 confirmed coronavirus c...

Comparison of T-piece and Pressure Support Ventilation Weaning from mechanical ventilation is one of the most importance challenges in the ICU. The longer the patients remain on the mechanical ventilator, the greater the risk of complications including longer ICU and hospital stay, higher rates of infection and greater mortality. In some patients, a spontaneous breathing trial (SBT) is conducted to determine if the patient will be able to sustain spontaneous breathi...

Original Investigation Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017 Jean-Louis Vincent, Yasser Sakr, Mervyn Singer, et al JAMA. Published online March 24, 2020. doi:10.1001/jama.2020.2717 Importance Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about the types of infections, causative pathogens, and outcomes can aid the development of policies for prevention, diagnosis,...

Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU Both acute liver failure (ALF) and acute on chronic liver failure (ACLF) are associated with high morbidity and mortality. Even today, medical treatment of these two disorders has limited benefits and for those who fail to respond, the only viable treatment is a liver transplant. Both ALF and ACLF rarely occur in isolation and in most cases there is multiple organ involvement. As with many critical...