Article Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock: a post hoc analysis of a randomized controlled trial Pirracchio R, Fong N, Legrand M. Intensive Care Med (2025). https://doi.org/10.1007/s00134-025-08104-8riginal Abstract Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arteri...

Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation In ICU Mon, 16 Jun 2025 Prolonged mechanical ventilation (MV) increases the risk of death, disability, and healthcare costs. Over one-third of patients entering the weaning phase experience difficulty, often due to diaphragm dysfunction. Traditional inspiratory muscle training has shown limited success.  Transvenous diaphragm neurostimulation, a novel method involvin...

Article Hemodynamic and neurological presentations of invasive meningococcal disease in adults: a nationwide study across 100+ French ICUs: The RETRO-MENINGO study Damien Contou, Benoit Painvin, Delphine Daubin, et al Intensive Care Med 2025; 51: 1587-1602 Abstract Purpose Invasive meningococcal disease (IMD) is a rare but potentially fatal infection caused by Neisseria meningitidis. In adults requiring admission to intensive care unit (ICU), I...

Articles Imbalance between muscle strength development and weight gain in children and young adults in China: serial cross-sectional evidence from 1.33 million students from five successive national surveys between 2000 and 2019 Xijie Wang, Huan Wang, Xin Yuan, et al Lancet Regional Health - Western Pacific 2025; 61: 101640 Summary Background Over the past decades, Chinese school-aged children and adolescents have experienced a rapid increase in overweig...

EDUCATION AND CLINICAL PRACTICE: ORIGINAL RESEARCH Impact of COVID-19 on Pulmonary Critical Care Fellows In-Training Exam Performance: A National Study Mahmoud Alwakeel, Paru Patrawalla, Brian Carlin, et al Chest 2025; 168: 710-718 Abstract Background Between 2020 and 2022, the COVID-19 pandemic disrupted health and education. Many training institutions modified trainees’ rotations, decreasing outpatient clinics while increasing inpatient and ICU time. U...

Conservative Oxygen Therapy in Mechanically Ventilated Patients In ICU Mon, 16 Jun 2025 Oxygen therapy is a common treatment in ICUs, traditionally given liberally to avoid hypoxaemia and its complications. However, excessive oxygen can also be harmful, making it important to balance oxygen levels. While many clinical trials have shown no significant difference in outcomes between conservative and liberal oxygen strategies in critically ill patients...

Original Investigation  Critical Care Medicine Outcomes of Critically Ill Adult Patients With Acute Encephalitis Romain Sonneville, Camille Couffignal, Bertrand Souweine, et al JAMA Netw Open 2025;8;(9):e2532478. doi:10.1001/jamanetworkopen.2025.32478 Key Points Question  What are the long-term functional outcomes of adults with severe encephalitis, and how do recovery trajectories differ by cause of ence...

Cluster-randomized Controlled Trial of Enhanced Carbapenem-resistant Enterobacterales Prevention Program in General Medicine Wards, Siriraj Hospital Apiradee Taweesuk, Pinyo Rattanaumpawan, Siriporn Rachakhom, et al Clin Infect Dis ciaf523, https://doi.org/10.1093/cid/ciaf523 Published: 22 September 2025 Abstract Background Carbapenem-resistant Enterobacterales (CRE) colonization is a major risk factor for infection. Most Infection Prevention and Control...

Nursing Care Considerations of Sepsis-Induced ARDS  In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 This article highlights sepsis early recognition and prevention to reduce the risk of developing sepsis-induced ARDS while emphasising pathophysiology, early recognition, and early intervention for both conditions. Introduction Sepsis, a life-threatening condition caused by a dysregulated immune response to...

Research Letter  Initial Antibiotic Selection Strategy and Subsequent Antibiotic Use—Insights From the INSPIRE Trials Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA 2025;334;(12):1107-1109 doi:10.1001/jama.2025.11256 Four cluster-randomized trials have demonstrated that a stewardship bundle including real-time computerized provider order entry (CPOE) prompts safely reduced initial extended-spectrum antibiotic use by 17% to 35% among adult p...