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Volume Controlled Ventilation does not Prevent Injurious Inflation during Spontaneous Effort
Takeshi Yoshida, Susumu Nakahashi, Maria Aparecida Miyuki Nakamura, et al
Am J Respir Crit Care Med 2017
Published on 17-February-2017 as 10.1164/rccm.201610-1972OC
Rationale: 背景
Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and tidal volume, and worsens lung injury. Intuitively, controlling tidal volume and transpulmonary pressure might li...
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Editorial
March 21, 2017
Optimizing the Settings on the Ventilator Settings: High PEEP for All?
Ary Serpa Neto, Marcus J. Schultz
JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2570
Mechanical ventilation is an effective life-support technique widely deployed across a variety of clinical settings in the care of many millions of patients each year worldwide. However, it is not a panacea. A central issue is that artificial ventilation works by pushing air ...
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Preliminary Communication | Caring for the Critically Ill Patient
March 21, 2017
Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications: A Randomized Clinical Trial
Alcino Costa Leme, Ludhmila Abrahao Hajjar, Marcia S. Volpe, et al
JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2297
Abstract
Importance 背景
Perioperative lung-protective ventilation has been recommende...
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Original Investigation | Caring for the Critically Ill Patient
March 21, 2017
Association Between US Norepinephrine Shortage and Mortality Among Patients With Septic Shock
Emily Vail, Hayley B. Gershengorn, May Hua, et al
JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2841
Abstract
Importance 背景
Drug shortages in the United States are common, but their effect on patient care and outcomes has rarely been reported.
在美国,药品短缺非常普遍,但其对于患者...
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Original Investigation | Caring for the Critically Ill Patient
March 21, 2017
Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial
Yu Kawazoe, Kyohei Miyamoto, Takeshi Morimoto, et al.
JAMA. Published online March 21, 2017. doi:10.1001/jama.2017.2088
Abstract
Importance 背景
Dexmedetomidine provides sedation for patients undergoing ventilation; however, its effects on m...
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Medscape Critical Care > Critical Issues
Evidence Lacking for Volume-Controlled Ventilation in Critical Care
Aaron B. Holley, MD
Disclosures | March 24, 2017
Volume Controlled Ventilation Does Not Prevent Injurious Inflation During Spontaneous Effort
Yoshida T, Nakahashi S, Nakamura MA, et al
Am J Respir Crit Care Med. 2017 Feb 17. [Epub ahead of print]
Background 背景
The ARDSNet trial of limited tidal volume (TV) has dictated ventilator settings for almost two decade...
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Persistent and Chronic Critical Illness
Revised and reviewed 11 December 2016
Persistent and Chronic Critical Illness
OVERVIEW
Advances in intensive care have led to a growing cohort of patients of patients, who would have otherwise succumbed to acute illness, survive in a state dependent on prolonged intensive care therapies including mechanical ventilation
heavy burden of costs to the individual, family and society
requires extreme use of resources
cause of considerabl...
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ORIGINAL ARTICLE
Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery
Rajendra H. Mehta, Jeffrey D. Leimberger, Sean van Diepen, et al.
March 19, 2017
DOI: 10.1056/NEJMoa1616218
BACKGROUND 背景
Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after cardiac surgery.
左西孟旦是一种强心药物,小样本研究显示其能够预防或治疗心脏外科术后低心排综合征。
METHODS 方法
In a m...
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ORIGINAL ARTICLE
Levosimendan for Hemodynamic Support after Cardiac Surgery
Giovanni Landoni, Vladimir V. Lomivorotov, Gabriele Alvaro, et al.
BACKGROUND 背景
Acute left ventricular dysfunction is a major complication of cardiac surgery and is associated with increased mortality. Meta-analyses of small trials suggest that levosimendan may result in a higher rate of survival among patients undergoing cardiac surgery.
急性左心室功能不全是心脏术后的主要并发症,伴随病死率升高...
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ORIGINAL ARTICLE
Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis
The PRISM Investigators
March 21, 2017
DOI: 10.1056/NEJMoa1701380
BACKGROUND 背景
After a single-center trial and observational studies suggesting that early, goal-directed therapy (EGDT) reduced mortality from septic shock, three multicenter trials (ProCESS, ARISE, and ProMISe) showed no benefit. This meta-analysis of individual patient data from the three recent trials was desi...
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