翻译：陈燕 Comment & Response August 3, 2020 The Uncertain Role of Corticosteroids in the Treatment of COVID-19—Reply Yuanlin Song, Chaomin Wu, Xiaoyan Chen JAMA Intern Med. Published online August 3, 2020. doi:10.1001/jamainternmed.2020.2435 In Reply In response to the concerns about survival bias and the findings regarding methylprednisolone in our Original Investigation,1 we treated methylprednis...

翻译：陈燕 Comment & Response August 3, 2020 The Uncertain Role of Corticosteroids in the Treatment of COVID-19 Theodore G. Liou, Frederick R. Adler, Nathan D. Hatton JAMA Intern Med. Published online August 3, 2020. doi:10.1001/jamainternmed.2020.2438 To the Editor Infection with coronavirus disease 2019 (COVID-19) causes exuberant lung inflammation leading to respiratory failure, acute respiratory dist...

Original Investigation March 13, 2020 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China Chaomin Wu, Xiaoyan Chen, Yanping Cai, et al JAMA Intern Med. 2020;180(7):934-943. doi:10.1001/jamainternmed.2020.0994 Abstract Importance 背景 Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequen...

Original Investigation August 18, 2020 Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial Ari Moskowitz, David T. Huang, Peter C. Hou, et al JAMA. 2020;324(7):642-650. doi:10.1001/jama.2020.11946 Abstract Importance 背景 The combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock. 联合应用维生素C、皮质...

Original Published: 11 August 2020 Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study Sung Yeon Hwang, Seung Mok Ryoo, Jong Eun Park, et al Intensive Care Med 2020 Purpose 目的 To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock. 评估静脉维生素C与维生素B1早期联合治疗...

ONLINE FIRST THIS WEEK(FREE ACCESS) Conference Reports and Expert Panel ~ Verweij P.E. et al. - Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion Systematic Review ~ Fleischmann-Struzek C. et al. - Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis Narrative Review&nbs...

The Landscape of COVID-19 Clinical Trials Introduction In an effort to gather evidence through scientifically rigorous trials to guide optimal management of COVID-19, researchers in the US have started multiple parallel clinical trials. In this systematic review, the researchers evaluate the characteristics and issues surrounding simultaneous trials being conducted.   Methods This systematic review, conducted in June 2020, used publicly ava...

Special Communication August 3, 2020 Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project David M. Greer, Sam D. Shemie, Ariane Lewis, et al JAMA. Published online August 3, 2020. doi:10.1001/jama.2020.11586 Abstract Importance 背景 There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internatio...

COVID-19: Neurological Associations The most common manifestation of COVID-19 has been respiratory illness with a growing recognition of neurological sequelae. In this recent review, researchers take into consideration the neurological features of COVID-19 and summarise the evidence available to suggest an investigation framework to guide future studies.  Before COVID-19, there were six other coronaviruses known to infect humans and cause respiratory pathology....

What is the Relevance of Cytokine Storm to COVID-19? COVID-19, in its most severe form, leads to life-threatening pneumonia and acute respiratory distress syndrome (ARDS). In patients with this severity of the coronavirus, mortality rate can approach 40 to 50%.  The mechanism of COVID-19 induced lung injury is still vague, but the term cytokine storm is being used quite frequently in scientific publications as well as the media. What is this cytokine storm and ...