CORRESPONDENCECRISC C2090-611 Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer Teresa Aydillo, Ana S. Gonzalez-Reiche, Sadaf Aslam, et al N Engl J Med December 1, 2020DOI: 10.1056/NEJMc2031670 TO THE EDITOR: Detection of replication-competent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most reliable indicator of contagiousness.1 Although the duration of live-virus shedding is well-characterized in immunoc...

ONLINE FIRST THIS WEEK(FREE ACCESS) Review ~ Demoule A. et al. - How to ventilate obstructive and asthmatic patients Review ~ Guérin C. et al. - Prone position in ARDS patients: why, when, how and for whom Review ~ Chanques G. et al. - Analgesia and sedation in patients with ARDSConference Reports and Expert Panel ~ Robba C. et al. - Mechanical ventilation in patients with acute b...

ORIGINAL ARTICLE REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19 David M. Weinreich, Sumathi Sivapalasingam, Thomas Norton, et al N Engl J Med December 17, 2020DOI: 10.1056/NEJMoa2035002 Abstract BACKGROUND Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. METHODS In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients wit...

Research Christmas 2020: House of God Estimating my equilibrium energy intake during lockdown: very introspective study R A Lewis BMJ 2020; 371: m4561 (Published 16 December 2020) doi: https://doi.org/10.1136/bmj.m4561 Abstract Objective To estimate the daily dietary energy intake for me to maintain a constant body weight. How hard can it be? Design Very introspective study. Setting At home. In lockdown. (Except every Tuesday afternoon a...

ORIGINAL ARTICLE Humoral Immune Response to SARS-CoV-2 in Iceland Daniel F. Gudbjartsson, Gudmundur L. Norddahl, Pall Melsted, et al N Engl J Med 2020; 383:1724-1734DOI: 10.1056/NEJMoa2026116 Abstract BACKGROUND Little is known about the nature and durability of the humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS We measured antibodies in serum samples from 30,576 persons in Iceland, u...

Research Christmas 2020: The Citadel Patient mortality after surgery on the surgeon’s birthday: observational study Hirotaka Kato, Anupam B Jena, Yusuke Tsugawa BMJ 2020; 371: m4381(Published 10 December 2020) doi: https://doi.org/10.1136/bmj.m4381 Abstract Objective To determine whether patient mortality after surgery differs between surgeries performed on surgeons’ birthdays compared with other days of the year. Design Retrospective observat...

ORIGINAL ARTICLE A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 ACTIV-3/TICO LY-CoV555 Study Group Abstract BACKGROUND LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Cov...

Research Christmas 2020: House of God The time to act is now: pseudo-systematic review Nathan Ford, Grania Brigden, Tom Ellman, et al BMJ 2020; 371:m4143 (Published 10 December 2020) doi: https://doi.org/10.1136/bmj.m4143  Abstract Objective To identify any medical or public health rationale for claims that the time to act is now. Design Pseudo-systematic review. Data sources PubMed. Study selection Studies that included the claim ...

Original Investigation Caring for the Critically Ill Patient Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS: A Randomized Clinical Trial Writing Committee and Steering Committee for the RELAx Collaborative Group JAMA. Published online December 9, 2020. doi:10.1001/jama.2020.23517 Abstract Importance It is uncertain whether invasive ventilation can use lower positive end-expirator...

ICU Management & Practice, Volume 20 - Issue 4, 2020 COVID-19, Corticosteroids and the Road to Enlightenment The use of corticosteroids for respiratory diseases has been a matter of discussion. Here, we present recent evidence of corticosteroids benefits for COVID-19, including improvements in mortality and ventilator-free days. More than six months riding treacherous waves in the COVID-19 storm had passed until a glimpse of a rudimentary old harbour app...