ARTICLES|ONLINE FIRST Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial Ivan Fan-Ngai Hung, Kwok-Cheung Lung, Eugene Yuk-Keung Tso, et al Lancet Published:May 08, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)31042-4 Summary Background Effective antiviral therapy is important for tackling the coronavirus disease 2019 (COVI...

JAMA Insights Clinical UpdateMarch 11, 2020 Care for Critically Ill Patients With COVID-19 Srinivas Murthy, Charles D. Gomersall, Robert A. Fowler JAMA. 2020;323(15):1499-1500. doi:10.1001/jama.2020.3633 Initial reports suggest that COVID-19 is associated with severe disease that requires intensive care in approximately 5% of proven infections.1 Given how common the disease is becoming, as in prior major severe acute respiratory infection outbreaks—S...

Editorials Remdesivir in covid-19 Robin E Ferner, Jeffrey K Aronson BMJ 2020; 369: m1610 doi: https://doi.org/10.1136/bmj.m1610 (Published 22 April 2020) A drug with potential—don’t waste time on uncontrolled observations The recent publication of an industry sponsored, open, non-randomised study of remdesivir in a heterogeneous patient population has added to the confusion surrounding the drug treatment of covid-19.1 The SARS-CoV-2 virus that causes cov...

Original Investigation April 22, 2020 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Safiya Richardson, Jamie S. Hirsch, Mangala Narasimhan, et al JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6775 Abstract Importance There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for...

May 6, 2020 Interpreting Diagnostic Tests for SARS-CoV-2 Nandini Sethuraman, Sundararaj Stanleyraj Jeremiah, Akihide Ryo JAMA. Published online May 6, 2020. doi:10.1001/jama.2020.8259 The pandemic of coronavirus disease 2019 (COVID-19) continues to affect much of the world. Knowledge of diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still evolving, and a clear understanding of the nature of the tests and interpre...

ORIGINAL ARTICLE Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19 Harmony R. Reynolds, Samrachana Adhikari, Claudia Pulgarin, et al N Engl J Med May 1, 2020DOI: 10.1056/NEJMoa2008975 Abstract BACKGROUND There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiot...

ORIGINAL ARTICLE Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19 Giuseppe Mancia, Federico Rea, Monica Ludergnani, et al N Engl J Med May 1, 2020DOI: 10.1056/NEJMoa2006923 Abstract BACKGROUND A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied. METHODS We carried out a po...

ORIGINAL ARTICLE Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 Mandeep R. Mehra, Sapan S. Desai, SreyRam Kuy, et al N Engl J Med May 1, 2020DOI: 10.1056/NEJMoa2007621 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) may disproportionately affect people with cardiovascular disease. Concern has been aroused regarding a potential harmful effect of angiotensin-converting–enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs...

Original Investigation April 6, 2020 Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy Giacomo Grasselli, Alberto Zangrillo, Alberto Zanella, et al JAMA. Published online April 6, 2020. doi:10.1001/jama.2020.5394 Abstract Importance In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread ...

Perspective Critical Supply Shortages — The Need for Ventilators and Personal Protective Equipment during the Covid-19 Pandemic Megan L. Ranney, Valerie Griffeth, Ashish K. Jha N Engl J Med 2020; 382:e41DOI: 10.1056/NEJMp2006141 On March 11, 2020, the World Health Organization designated “coronavirus disease 2019” (Covid-19) a global pandemic. As the number of cases in the United States continues to grow, political leaders are encouraging physical (or “social”...