CORRESPONDENCE Covid-19 and Kidney Transplantation NEJM April 24, 2020DOI: 10.1056/NEJMc2011117 TO THE EDITOR: Kidney-transplant recipients appear to be at particularly high risk for critical Covid-19 illness due to chronic immunosuppression and coexisting conditions.1 At Montefiore Medical Center, we identified 36 consecutive adult kidney-transplant recipients who tested positive for Covid-19 between March 16 and April 1, 2020. A total of 26 recipients (...

Research Letter May 15, 2020 Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure Xavier Elharrar, Youssef Trigui, Anne-Marie Dols, et al JAMA. Published online May 15, 2020. doi:10.1001/jama.2020.8255 Patients with coronavirus disease 2019 (COVID-19) are at risk for acute respiratory distress syndrome.1 In intubated patients with severe acute respiratory distress syndrome, early and prolonged (...

April 14, 2020 Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial Nina Singh, Drew J. Winston, Raymund R. Razonable, et al. JAMA. 2020;323(14):1378-1387. doi:10.1001/jama.2020.3138 Abstract Importance Despite the use of a cytomegalovirus (CMV) prevention strategy of antiviral prophylaxis for high-risk CMV-seronegative ...

Practice Practice Pointer Interpreting a covid-19 test result Jessica Watson, Penny F Whiting, John E Brush BMJ 2020; 369: m1808 doi: https://doi.org/10.1136/bmj.m1808 (Published 12 May 2020) What you need to know Interpreting the result of a test for covid-19 depends on two things: the accuracy of the test, and the pre-test probability or estimated risk of disease before testingA positive RT-PCR test for covid-19 test has more weight than a negative t...

Viewpoint April 6, 2020 The COVID-19 Pandemic in the USA: Clinical Update Saad B. Omer, Preeti Malani, Carlos del Rio JAMA. 2020;323(18):1767-1768. doi:10.1001/jama.2020.5788 Since the first US case of coronavirus disease 2019 (COVID-19) infection as identified in Washington State on January 20, 2020, more than 235 000 cases have been identified across the US in just over 2 months. Given the challenges in expanding testing capacity and the restrictive cas...

Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials Lancet 2020; 395: 1506-1515 Summary Background The timing of renal replacement therapy (RRT) for severe acute kidney injury is highly debated when no life-threatening complications are present. We assessed whether a strategy of delayed versus early RRT initiation affects 28-day ...

CORRESPONDENCE Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy N Engl J Med April 29, 2020DOI: 10.1056/NEJMc2010418 TO THE EDITOR: Despite the risk of rapid respiratory failure1 and cardiac complications2 due to Covid-19, it is unclear whether there is an association between Covid-19 and out-of-hospital cardiac arrest. The Lombardy region of Italy was among the first areas to have an outbreak of Covid-19 outside China,3 and ...

Original Investigation May 11, 2020 Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Eli S. Rosenberg, PElizabeth M. Dufort, Tomoko Udo, et al JAMA. Published online May 11, 2020. doi:10.1001/jama.2020.8630 Abstract Importance Hydroxychloroquine, with or without azithromycin, has been considered as a possible therapeutic agent for patients with coronavir...

ORIGINAL ARTICLE Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Joshua Geleris, Yifei Sun, Jonathan Platt, et al N Engl J Med May 7, 2020DOI: 10.1056/NEJMoa2012410 Abstract BACKGROUND Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use. METHODS We examined the association between hydroxychloroquine use and intubation or death at a large medical center...

ARTICLES|ONLINE FIRST Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Giulio Cavalli, Giacomo De Luca, Corrado Campochiaro, et al Lancet Rheumatol Published:May 07, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30127-2 Summary Background Mortality of patients with coronavirus disease 2019 (COVID-19), acute respiratory distress syndrome (ARD...