Research Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis Mayara Lisboa Bastos, Gamuchirai Tavaziva, Syed Kunal Abidi, et al BMJ 2020; 370: m2516 doi: https://doi.org/10.1136/bmj.m2516 (Published 01 July 2020) Abstract Objective 目的 To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19). 确定新冠病毒感染(COVID-19)血清学检查的诊断准确性。 Design 设计 Systematic ...

COVID-19: Molecular Mechanisms of Gender Differences The COVID-19 pandemic has resulted in hundreds of thousands of deaths around the globe. An important thing to note is that more men have died from COVID-19 than women. A European study shows that men had a slightly higher incidence of COVID-19 with no respiratory distress compared to women. Still, more males with COVID-19 developed severe respiratory failure compared to females. Other studies also show that men are m...

翻译：陈燕 Comment & Response August 3, 2020 The Uncertain Role of Corticosteroids in the Treatment of COVID-19—Reply Yuanlin Song, Chaomin Wu, Xiaoyan Chen JAMA Intern Med. Published online August 3, 2020. doi:10.1001/jamainternmed.2020.2435 In Reply In response to the concerns about survival bias and the findings regarding methylprednisolone in our Original Investigation,1 we treated methylprednis...

翻译：陈燕 Comment & Response August 3, 2020 The Uncertain Role of Corticosteroids in the Treatment of COVID-19 Theodore G. Liou, Frederick R. Adler, Nathan D. Hatton JAMA Intern Med. Published online August 3, 2020. doi:10.1001/jamainternmed.2020.2438 To the Editor Infection with coronavirus disease 2019 (COVID-19) causes exuberant lung inflammation leading to respiratory failure, acute respiratory dist...

Original Investigation March 13, 2020 Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China Chaomin Wu, Xiaoyan Chen, Yanping Cai, et al JAMA Intern Med. 2020;180(7):934-943. doi:10.1001/jamainternmed.2020.0994 Abstract Importance 背景 Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequen...

Original Investigation August 18, 2020 Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial Ari Moskowitz, David T. Huang, Peter C. Hou, et al JAMA. 2020;324(7):642-650. doi:10.1001/jama.2020.11946 Abstract Importance 背景 The combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock. 联合应用维生素C、皮质...

Original Published: 11 August 2020 Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study Sung Yeon Hwang, Seung Mok Ryoo, Jong Eun Park, et al Intensive Care Med 2020 Purpose 目的 To evaluate the effects of early combination therapy with intravenous vitamin C and thiamine on recovery from organ failure in patients with septic shock. 评估静脉维生素C与维生素B1早期联合治疗...

ONLINE FIRST THIS WEEK(FREE ACCESS) Conference Reports and Expert Panel ~ Verweij P.E. et al. - Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion Systematic Review ~ Fleischmann-Struzek C. et al. - Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis Narrative Review&nbs...

The Landscape of COVID-19 Clinical Trials Introduction In an effort to gather evidence through scientifically rigorous trials to guide optimal management of COVID-19, researchers in the US have started multiple parallel clinical trials. In this systematic review, the researchers evaluate the characteristics and issues surrounding simultaneous trials being conducted.   Methods This systematic review, conducted in June 2020, used publicly ava...

Special Communication August 3, 2020 Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project David M. Greer, Sam D. Shemie, Ariane Lewis, et al JAMA. Published online August 3, 2020. doi:10.1001/jama.2020.11586 Abstract Importance 背景 There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internatio...