Original Investigation January 21, 2021 Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial Robert L. Gottlieb, Ajay Nirula, Peter Chen, et al JAMA. 2021;325(7):632-644. doi:10.1001/jama.2021.0202 Abstract Importance Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for C...

ORIGINAL ARTICLE A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis Louise China, Nick Freemantle, Ewan Forrest, et al N Engl J Med 2021; 384:808-817 Abstract BACKGROUND Infection and increased systemic inflammation cause organ dysfunction and death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials are lacking. Wh...

ORIGINAL ARTICLE Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia Ivan O. Rosas, Norbert Bräu, Michael Waters, et al N Engl J Med February 25, 2021DOI: 10.1056/NEJMoa2028700 Abstract BACKGROUND Coronavirus disease 2019 (Covid-19) is associated with immune dysregulation and hyperinflammation, including elevated interleukin-6 levels. The use of tocilizumab, a monoclonal antibody against the interleukin-6 receptor, has resulted in better ...

2020年引用最多论文  Understanding the disease ~ Zang H. et al. - Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Letter ~ Ruan Q. et al. ~Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Guidelines ~ Alhazzani W. et al. - Surviving Sepsis Campaign: guidelines on the management of cr...

COVID-19 Consequences Six Months After Symptom Onset Findings from a follow-up study conducted with 1733 patients first diagnosed in Wuhan, China, show that nearly 76% of these patients had at least one symptom six months after symptom onset. Findings are published in The Lancet. The study included patients discharged from Jin Yin-tan Hospital in Wuhan, China, who were diagnosed with COVID-19 between January and May and who were followed to June and September. ...

Editorials Covid-19 controversies: the tocilizumab chapter Erin K McCreary, Nuala J Meyer BMJ 2021; 372: n244 doi: https://doi.org/10.1136/bmj.n244 The signals are broadly positive, but not definitive More than two million people have so far died from coronavirus disease 2019 (covid-19) globally. With hospitals and intensive care units at or exceeding capacity in much of the world, discovering life-saving treatments is second only to global vaccination effo...

表1. 怀疑或确诊产ESBL肠杆菌感染的推荐抗生素治疗选择（假设对表格中列举的抗生素体外敏感） 表2. 耐碳青霉烯肠杆菌(CRE)感染的推荐抗生素治疗选择（假设对表格中列举的抗生素体外敏感） 表3. 难治性耐药(DTR)铜绿假单胞菌感染的推荐抗生素治疗选择（假设对表格中列举的抗生素体外敏感）

ONLINE FIRST THIS WEEK(FREE ACCESS)  Original ~ Buetti N. et al. - COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA networkEditorial ~ Dale C.M. et al. - Leaving a mark: pressure injury research in the intensive care unitLetter ~ Proudfoot A.G. et al. - Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experienceCorrespondence ~ Meduri...

Research Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial Viviane C Veiga, João A G G Prats, Danielle L C Farias, et al BMJ 2021; 372: n84 doi: https://doi.org/10.1136/bmj.n84 Abstract Objective To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open labe...

Original Investigation Caring for the Critically Ill PatientFebruary 23, 2021 Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial Jonathan E. Sevransky, Richard E. Rothman, David N. Hager, et al JAMA. 2021;325(8):742-750. doi:10.1001/jama.2020.24505 Abstract Importance Sepsis is a common syndrome with substantial morbidity and mortality. A ...