COVID-19 Consequences Six Months After Symptom Onset Findings from a follow-up study conducted with 1733 patients first diagnosed in Wuhan, China, show that nearly 76% of these patients had at least one symptom six months after symptom onset. Findings are published in The Lancet. The study included patients discharged from Jin Yin-tan Hospital in Wuhan, China, who were diagnosed with COVID-19 between January and May and who were followed to June and September. ...

Editorials Covid-19 controversies: the tocilizumab chapter Erin K McCreary, Nuala J Meyer BMJ 2021; 372: n244 doi: https://doi.org/10.1136/bmj.n244 The signals are broadly positive, but not definitive More than two million people have so far died from coronavirus disease 2019 (covid-19) globally. With hospitals and intensive care units at or exceeding capacity in much of the world, discovering life-saving treatments is second only to global vaccination effo...

表1. 怀疑或确诊产ESBL肠杆菌感染的推荐抗生素治疗选择（假设对表格中列举的抗生素体外敏感） 表2. 耐碳青霉烯肠杆菌(CRE)感染的推荐抗生素治疗选择（假设对表格中列举的抗生素体外敏感） 表3. 难治性耐药(DTR)铜绿假单胞菌感染的推荐抗生素治疗选择（假设对表格中列举的抗生素体外敏感）

ONLINE FIRST THIS WEEK(FREE ACCESS)  Original ~ Buetti N. et al. - COVID-19 increased the risk of ICU-acquired bloodstream infections: a case–cohort study from the multicentric OUTCOMEREA networkEditorial ~ Dale C.M. et al. - Leaving a mark: pressure injury research in the intensive care unitLetter ~ Proudfoot A.G. et al. - Rapid establishment of a COVID-19 critical care unit in a convention centre: the Nightingale Hospital London experienceCorrespondence ~ Meduri...

Research Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial Viviane C Veiga, João A G G Prats, Danielle L C Farias, et al BMJ 2021; 372: n84 doi: https://doi.org/10.1136/bmj.n84 Abstract Objective To determine whether tocilizumab improves clinical outcomes for patients with severe or critical coronavirus disease 2019 (covid-19). Design Randomised, open labe...

Original Investigation Caring for the Critically Ill PatientFebruary 23, 2021 Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial Jonathan E. Sevransky, Richard E. Rothman, David N. Hager, et al JAMA. 2021;325(8):742-750. doi:10.1001/jama.2020.24505 Abstract Importance Sepsis is a common syndrome with substantial morbidity and mortality. A ...

Original Investigation January 19, 2021 Effect of Discontinuing vs Continuing Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on Days Alive and Out of the Hospital in Patients Admitted With COVID-19: A Randomized Clinical Trial Renato D. Lopes, Ariane V. S. Macedo, Pedro G. M. de Barros E Silva, et al JAMA. 2021;325(3):254-264. doi:10.1001/jama.2020.25864 Abstract Importance It is unknown whether angiotensin-c...

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial  RECOVERY Collaborative Group Lancet 2021; 397: 605–12  https://doi.org/10.1016/ S0140-6736(21)00149-5  Summary  Background Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID...

Original Investigation January 19, 2021 Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial Wenjie Zi, Zhongming Qiu, Fengli Li, et al JAMA. 2021;325(3):234-243. doi:10.1001/jama.2020.23523 Abstract Importance For patients with large vessel occlusion strokes, it is unknown whether endovascular treatm...

Original Investigation Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children Naïm Ouldali, MD, Julie Toubiana, Denise Antona, et al JAMA. Published online February 1, 2021. doi:10.1001/jama.2021.0694 Abstract Importance Multisystem inflammatory syndrome in children (MIS-C) is the most severe pediatric disease associated with severe acute respirator...