ECMO for COVID-19 Extracorporeal membrane oxygenation (ECMO) has been used in patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS). ECMO has previously been used in other infectious outbreaks, including the 2009 influenza A (H1N1) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) outbreak. The Extracorporeal Life Support Organisation (ELSO), the World Health Organization and the Surviving Sepsis Campaign (SSC) guidel...

ARTICLES|ONLINE FIRST Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial JoAnn Lindenfeld, Michael R Zile, Akshay S Desai, et al Lancet Published:August 27, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)01754-2 Summary Background Previous studies have suggested that haemodynamic-guided management using an implantable pulmonary artery pressure monitor reduces heart failure hospitalisations in patients with moderatel...

Impact of Multimorbidity on Long-Term Outcomes After ICU Discharge Critical care admissions continue to increase year after year. There is also increasing evidence that demonstrates discharge from critical care as the start of a challenging process for both patients and caregivers, with many survivors going through physical, social, cognitive, and emotional problems in the years following discharge. It is clinically proven that people who survive critical i...

ORIGINAL ARTICLE Early Convalescent Plasma for High-Risk Outpatients with Covid-19 Frederick K. Korley, Valerie Durkalski-Mauldin, Sharon D. Yeatts, et al N Engl J Med August 18, 2021DOI: 10.1056/NEJMoa2103784 Abstract BACKGROUND Early administration of convalescent plasma obtained from blood donors who have recovered from coronavirus disease 2019 (Covid-19) may prevent disease progression in acutely ill, high-risk patients with Covid-19. METHODS I...

ICU Management & Practice, Volume 20 - Issue 3, 2020 Infographic Problems associated with ageing, complications of critical illness in the elderly patient, and an overview of the gaps in the treatment of critically ill older adults.

Research Letter August 13, 2021 Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection Zion Congrave-Wilson, Yesun Lee, Jaycee Jumarang, et al JAMA. Published online August 13, 2021. doi:10.1001/jama.2021.13967 While real-time reverse transcriptase–polymerase chain reaction (RT-PCR) on nasopharyngeal swabs is the current standard for SARS-CoV-2 detection, saliva is an attractive alternative...

ARTICLES|ONLINE FIRST Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial PRISM trial group Lancet Respir Med Published:June 18, 2021 DOI: https://doi.org/10.1016/S2213-2600(21)00089- Summary Background Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuou...

VIEWPOINT| VOLUME 9, ISSUE 8, P933-936, AUGUST 01, 2021 The Berlin definition of acute respiratory distress syndrome: should patients receiving high-flow nasal oxygen be included? Michael A Matthay, B Taylor Thompson, Lorraine B Ware Lancet Respir Med 2021; 9: 933-936 Summary The 2012 Berlin definition of acute respiratory distress syndrome (ARDS) provided validated support for three levels of initial arterial hypoxaemia that correlated with ...

Protective Ventilation and Outcomes in Patients with COVID-19 The coronavirus pandemic continues to be a global health issue. Clinical outcomes data of patients from China, Europe and the U.S. show high mortality among critically ill patients with COVID-19, especially those who required mechanical ventilation. Among patients with COVID-19, approximately 5% develop respiratory failure that requires ventilatory support. However, very little is known about the impa...

ARTICLES| VOLUME 9, ISSUE 8, P863-872, AUGUST 01, 2021 Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial Axel Bauer, Michael Schreinlechner, Nikolay Sappler, et al Lancet Respir Med 2021; 9: 863-872 DOI:https://doi.org/10.1016/S2213-2600(21)00214-9 Summary Background SARS-CoV-2 entry in human cells depends on angiotens...