ARTICLES| VOLUME 9, ISSUE 9, P957-968, SEPTEMBER 01, 2021 Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial Jurjan Aman, Erik Duijvelaar, Liza Botros, et al Lancet Respir Med 2021; 9: 957-968 DOI:https://doi.org/10.1016/S2213-2600(21)00237-X Summary Background The major complication of COVID-19 is hypoxaemic respiratory failure from capillary leak and alveolar oedema. Experimental ...

ICU Management & Practice, Volume 21 - Issue 3, 2021 Apnoeic Oxygenation for Intubation - Where is the Evidence? Apnoeic oxygenation can be used in critically ill patients, without replacing preoxygenation. Introduction Hypoxaemia is one of the most common complications during tracheal intubation of critically ill patients (Jaber et al. 2006; Russotto et al. 2021) with an incidence of severe hypoxaemia reaching up to 50% (De Jong et al. 2013; Jaber et...

ARTICLES| VOLUME 9, ISSUE 9, P989-998, SEPTEMBER 01, 2021 Clinical characteristics and outcomes of invasively ventilated patients with COVID-19 in Argentina (SATICOVID): a prospective, multicentre cohort study Elisa Estenssoro, Cecilia I Loudet, Fernando G Ríos, et al Lancet Respir Med 2021; 9: 989-998 DOI:https://doi.org/10.1016/S2213-2600(21)00229-0 Summary Background Although COVID-19 has greatly affected many low-income and mid...

ICU Management & Practice, Volume 21 - Issue 3, 2021 New Applications of Pulse Oximetry The clinical applications of pulse oximetry go far beyond the mere monitoring of SpO2. From home to ICUs, pulse oximeters may help to improve quality of care in patients with respiratory and circulatory disorders, in particular those with the coronavirus disease 2019 (COVID-19).Pulse oximetry was developed in the 1970’s to monitor oxygen saturation (SpO2) during anaesthe...

ARTICLES| VOLUME 9, ISSUE 8, P851-862, AUGUST 01, 2021 Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study Guillaume Lebreton, Matthieu Schmidt, Maharajah Ponnaiah, et al Lancet Respir Med 2021; 9: 851-862 DOI:https://doi.org/10.1016/S2213-2600(21)00096-5 Summary Background In the Île-de-France region (henceforth termed Greater P...

ORIGINAL ARTICLE Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis Lotte Boxhoorn, Sven M. van Dijk, Janneke van Grinsven, et al N Engl J Med 2021; 385:1372-1381DOI: 10.1056/NEJMoa2100826 Abstract BACKGROUND Infected necrotizing pancreatitis is a potentially lethal disease that is treated with the use of a step-up approach, with catheter drainage often delayed until the infected necrosis is encapsulated. Whether outcomes could...

ARTICLES|ONLINE FIRST Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial Jean-Marc Naccache, Stéphane Jouneau, Morgane Didier, et al Lancet Respir Med Published:September 07, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00354-4 Summary Background The use of cyclophosphamide in patients with acute exacerbation of idiopathic pulmonary ...

Sex, Illness Severity and Mortality in ICU Patients Women account for only about 35-45% of patients in the ICU. This is surprising since half of the world’s population are women. This highlights a very pertinent question: do men and women have equitable access to the ICU? There have been several clinical studies that have tried to determine sex differences in illness severity and survival. However, there have been no consistent results. Some studies show no diff...

ARTICLES|ONLINE FIRST Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial Stephan Ehrmann, Jie Li, Miguel Ibarra-Estrada, et al Lancet Respir Med Published:August 20, 2021 DOI:https://doi.org/10.1016/S2213-2600(21)00356-8 Summary Background Awake prone positioning has been reported to improve oxygenation for patients with COVID-19 in retrospective and observational s...

Application of Artificial Intelligence in the ICU Artificial Intelligence (AI) holds great promise in critical care. Vast amounts of data are regularly collected in intensive care units, making ICUs the perfect environment for deploying machine-learning techniques. AI in ICUs can have several applications. For example, when determining the short and long-term outcomes of different interventions, a well-designed ICU system could provide significant support in the...