ICU Management & Practice, Volume 21 - Issue 1, 2021 Prone Position in Awake, Non-Intubated Patients with ARDS: From Physiology to the Bedside Prone position (PP) in awake, non-intubated patients with respiratory failure is a physiology-based ventilatory strategy that improves oxygenation and may decrease the need for intubation and invasive mechanical ventilation (IMV). Introduction During the pandemic caused by the SARS-CoV-2 virus, which produces c...

Original Investigation Caring for the Critically Ill PatientMarch 23/30, 2021 Ventilator Weaning and Discontinuation Practices for Critically Ill Patients Karen E. A. Burns, Leena Rizvi, Deborah J. Cook, et al JAMA. 2021;325(12):1173-1184. doi:10.1001/jama.2021.2384 Abstract Importance 背景 Although most critically ill patients receive invasive mechanical ventilation (IMV), few studies have characterized ...

CDC Interim Guidelines for Fully Vaccinated People Efforts to end the COVID-19 pandemic finally became possible when, in December 2020, the FDA authorised the use of the first COVID-19 vaccine, manufactured by Pfizer-BioNTech. Soon after, two additional vaccines from Moderna and Johnson & Johnson also received emergency authorisation for use. As of 8 March 2021, over 31 million people in the U.S. have completed their vaccination.  As the number of ...

ORIGINAL ARTICLE Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial Rianne van Rijn, Ivo J. Schurink, Yvonne de Vries, et al N Engl J Med 2021; 384:1391-1401DOI: 10.1056/NEJMoa2031532 Abstract BACKGROUND Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of bili...

Original Investigation Caring for the Critically Ill PatientMarch 23/30, 2021 Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries Vincenzo Russotto, Sheila Nainan Myatra, John G. Laffey, et al JAMA. 2021;325(12):1164-1172. doi:10.1001/jama.2021.1727 Abstract Importance 背景 Tracheal intubation is one of the most commonly performed and high-risk intervention...

ICU Management & Practice, Volume 21 - Issue 1, 2021 Twenty Lessons from 2020: With a Focus on the ICU Perspective 2020 has been an unusual year. As we begin 2021, it is important for intensivists to look back over what has happened and see whether lessons can be learned from our combined experiences.The year 2020 has been unusual in so many ways and as we start a new year, it is interesting and important as intensivists to look back and reflect on what has...

全剂量接种疫苗人群临时公共卫生建议 2021年3月8日更新 要点 这是针对全剂量接种疫苗人群的第一套公共卫生建议。本指导方针将根据SARS-CoV-2的社区传播水平、全剂量接种疫苗人口比例以及COVID-19疫苗科学的迅速发展而进行更新和扩充。 出于本指导方针的目的，接种2剂COVID-19系列疫苗（辉瑞生物科技或莫德纳）的第二剂2周后，或在接种单剂疫苗（强生[J&J]/杨森）2周后，人们才被认为完成全剂量接种疫苗。 以下建议适用于非医疗护理环境。有关医疗护理环境的相关信息，请参阅应对COVID-19免疫...

Solidarity Trial Interim Results: Antiviral Drugs in Hospitalised COVID-19 Patients Mortality trials of four antiviral drugs - remdesivir, hydroxychloroquine, lopinavir and interferon beta-1a were recommended by the World Health Organization (WHO) to evaluate their effect in patients hospitalised with COVID-19. In March 2020, the WHO began a large international trial that included hospital inpatients to evaluate the effects of these four drugs on in-hospital mortali...

High-flow Nasal Oxygen vs. Invasive Mechanical Ventilation in COVID-19 COVID-19 has caused thousands of cases of acute respiratory failure with a high mortality rate. However, so far, the use of high-flow nasal oxygen (HFNO) has been limited even though it may be an appropriate initial therapy in COVID-19 patients with acute respiratory failure. The use of invasive mechanical ventilation remains the primary treatment strategy in this patient population.  C...

Original Investigation March 4, 2021 Effect of Ivermectin on Time to Resolution of Symptoms Among Adults With Mild COVID-19: A Randomized Clinical Trial Eduardo López-Medina, Pío López, Isabel C. Hurtado, et al JAMA. Published online March 4, 2021. doi:10.1001/jama.2021.3071 Abstract Importance Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit. Objective To determine ...