ORIGINAL ARTICLE Treatment of Multisystem Inflammatory Syndrome in Children Andrew J. McArdle, Ortensia Vito, Harsita Patel, et al N Engl J Med June 16, 2021DOI: 10.1056/NEJMoa2102968 Abstract BACKGROUND Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS We performed an international observational cohort ...

ICU Management & Practice, Volume 21 - Issue 2, 2021 The Challenge of Admitting a Very Old Patient with Sepsis to an Intensive Care Unit Sepsis incidence in very old patients is high and related mortality and morbidity are a major health concern. Frailty and severity of illness, not just age or sepsis diagnosis, are the determinant factors in outcome. Early identification and treatment are decisive in their survival. Nowadays, we are facing some importan...

CCBYNC Open accessResearch Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial Michael J Kovacs, Philip S Wells, David R Anderson, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1205 (Published 09 June 2021)Cite this as: BMJ 2021;373:n1205 Abstract Objective To determine the efficacy and safety of dalteparin postoperative brid...

ONLINE FIRST (FREE ACCESS) OriginalImplementation of new ECMO centers during the COVID-19 pandemic: experience and results from the Middle East and IndiaRabie A.A. et al. COVID-19 in Intensive CareCritical care after the COVID-19 outbreak in China: lessons and renaissanceXie J. et al.Delirium in COVID-19: can we make the unknowns knowns?Wilcox M.E. et al.  OPEN ACCESS ~ Conference Reports and Expert PanelTaskforce report on the diagnosis an...

ICU Management & Practice, Volume 21 - Issue 2, 2021 Compassion and Humanism in the ICU – A Clinical Study Importance and Objectives To observe the impact and main contributing factors of stress, anxiety and depression among frontline staff in the intensive care units during the COVID-19 pandemic, and to determine if wellness resources are useful. Design Mixed method observational cohort study. Setting and Participants All frontline...

Research Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries Nazrul Islam, Vladimir M Shkolnikov, Rolando J Acosta, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1137 (Published 19 May 2021)Cite this as: BMJ 2021;373:n1137 Abstract Objective To estimate the direct and indirect effects of the covid-19 pandemic on mortality in 2020 in 29 high income countries with rel...

12 Things to Do to Improve Wellbeing in the ICU An overview of strategies and measures that can be implemented to improve wellbeing of staff and patients in the ICU. 1. Make the patient the centre of our preoccupations This is the first principle of wellbeing in the ICU and should be written in large letters when one enters an ICU. Wellbeing must concern first and foremost the patient. The patient should be positioned, figuratively, at the centre of the ICU room,...

Research Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study Sarah E Daugherty, Yinglong Guo, Kevin Heath, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1098 (Published 19 May 2021)Cite this as: BMJ 2021;373:n1098 Abstract Objective To evaluate the excess risk and relative hazards for developing incident clinical sequelae after the acute phase of SARS-CoV-2 infection in adults aged 18-65. Design ...

Post-Acute Sequalae of COVID-19 Findings from a large comprehensive study of COVID-19 show that COVID-19 survivors - even those with mild symptoms - have to deal with a variety of health problems long after the infection has resolved. Study findings show that COVID-19 survivors, including those not hospitalised, had an increased risk of death six months after a COVID-19 diagnosis.  These findings highlight the long-term burden of this disease and how i...

Research Effect of dexamethasone on complications or all cause mortality after major non-cardiac surgery: multicentre, double blind, randomised controlled trial Karim Asehnoune, Charlene Le Moal, Gilles Lebuffe, et al BMJ 2021; 373 doi: https://doi.org/10.1136/bmj.n1162 (Published 02 June 2021)Cite this as: BMJ 2021;373:n1162 Abstract Objective To assess the effect of dexamethasone on complications or all cause mor...