Original Investigation May 26, 2021 Effect of 2 Inactivated SARS-CoV-2 Vaccines on Symptomatic COVID-19 Infection in Adults: A Randomized Clinical Trial Nawal Al Kaabi, Yuntao Zhang, Shengli Xia, et al JAMA. Published online May 26, 2021. doi:10.1001/jama.2021.8565 Abstract Importance Although effective vaccines against COVID-19 have been developed, additional vaccines are still needed. Objective To evaluate the efficacy and adverse ...

ORIGINAL ARTICLE Dexamethasone and Surgical-Site Infection Tomás B. Corcoran, Paul S. Myles, Andrew B. Forbes, et al N Engl J Med 2021; 384:1731-1741DOI: 10.1056/NEJMoa2028982 Abstract BACKGROUND The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection. METHODS In this pragmatic, international, noninferiority trial, we randomly assigned 8880 adult pati...

#EA20: Wellbeing of Healthcare Providers During COVID-19 In a three-part session on burnout and depression of healthcare providers during COVID-19: diagnosis and approach at Euroanaesthesia 2020, Dr. Miodrag Milenovic of University of Belgrade and Clinical Center of Serbia, Emergency Center, talked about the occupational wellbeing in healthcare providers during the pandemic.  Dr. Milenovic highlighted the fact that the field of anaesthesiology is already quite ...

Original Investigation May 4, 2021 Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial Siri Lillegraven, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, et al JAMA. 2021;325(17):1755-1764. doi:10.1001/jama.2021.4542 Abstract Importance Sustained remission has become an achievable goal f...

#EA20: Is Technology the Answer for Perioperative Patient Safety? One of the most enjoyable sessions at Euroanaesthesia 2020 this year was the pro-con debate. The debate this time was on the topic: is technology the final answer for perioperative patient safety? Two experts, Dr. Daniel Arnal from the  Hospital Universitario Fundación Alcorcón, Madrid, Spain, delivered the pro argument, while Prof. William Harrop-Griffiths from Imperial College, London, UK, deli...

ORIGINAL ARTICLE Tranexamic Acid for the Prevention of Blood Loss after Cesarean Delivery Loïc Sentilhes, Marie V. Sénat, Maëla Le Lous, et al N Engl J Med 2021; 384:1623-1634DOI: 10.1056/NEJMoa2028788 Abstract BACKGROUND Prophylactic administration of tranexamic acid has been associated with reduced postpartum blood loss after cesarean delivery in several small trials, but evidence of its benefit in this clinical context remains inconclusive. METHODS...

ICU Management & Practice, Volume 20 - Issue 4, 2020 Treatment of Catecholamine Refractory Hypotension in Septic Shock: Beyond First Line Vasopressor Hypotension during septic shock is a strong indicator of patient outcome and mortality. Arginine vasopressin is a naturally produced human hormone with vasoconstriction effect via V1 receptor activation and a short 5-20 minutes half-life and is recommended by the Surviving Sepsis Campaign guidelines to be adde...

ORIGINAL ARTICLE Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 The REMAP-CAP Investigators N Engl J Med 2021; 384:1491-1502DOI: 10.1056/NEJMoa2100433 Abstract BACKGROUND The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adul...

Prevalence and Risk Factors for Delirium in COVID-19 ICU Patients According to findings from a large study, COVID-19 patients admitted to the ICU in the early months of the pandemic had a higher burden of delirium and coma than is typically found in patients with acute respiratory failure. The findings are published in The Lancet Respiratory Medicine. Study investigators tracked the incidence of delirium and coma in 2088 COVID-19 patients admitted in the ICU be...

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:May 14, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00897-7 Summary Background Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to ho...