News & Perspective CDC: Legionnaires' at Healthcare Sites Is 'Widespread, Deadly' Marcia Frellick June 06, 2017 People are getting Legionnaires' disease from healthcare facilities — primarily long-term care facilities — in most parts of the country, Anne Schuchat, MD (RADM, USPHS), acting director of the Centers for Disease Control and Prevention (CDC), told reporters on a conference call Tuesday. Reports from 2015 in 20 states and New York City were studied and t...

News & Perspective C auris: CDC Warns of Institutional Spread, Updates Guidance Janis C. Kelly May 18, 2017 The emerging and often drug-resistant fungus Candida auris continues to spread in the United States, the Centers for Disease Control and Prevention (CDC) reported today. Less than a year after the first seven cases of C auris were reported in the United States, the agency now says there have been 77 patient cases, and another 45 cases have been identified v...

News & Perspective Attack in Manchester: Emergency Services Response Isabelle Catala, MD May 26, 2017 MANCHESTER, UK — The suicide attack that took place as people were leaving the Ariana Grande concert at the Manchester Arena on May 22 injured more than 60 attendees and killed 22 people (12 of whom, between the ages of 8 and 50, have been identified as at May 24). Emergency services were quickly deployed in accordance with national recommendations put in place i...

Original Investigation Caring for the Critically Ill Patient Discriminative Accuracy of Physician and Nurse Predictions for Survival and Functional Outcomes 6 Months After an ICU Admission Michael E. Detsky, Michael O. Harhay, Dominique F. Bayard, et al JAMA. Published online May 21, 2017. doi:10.1001/jama.2017.4078 Abstract Importance 背景 Predictions of long-term survival and functional outcomes influence decision making for critically ill patients, yet little is k...

Drugs & Diseases > Clinical Trends Clinical Trends for May 2017 Ryan Syrek May 26, 2017 Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what's trending and why, feel free to share them with us on Twitter or Facebook! Clinical Trend of the Week (May 20-26): NSAIDs Some troubling news about a popular class of drugs resulted in this week's top search...

本周在线发表文章（免费阅读） ONLINE FIRST THIS WEEK (FREE ACCESS) Review ~ Alain Combes et al. The ICM research agenda on extracorporeal life support. Original ~ Jean-François Timsit et al. Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE’s STAT-Net. Original ~ Frank Bloos et al. Effect of a multifaceted educational intervention for anti-infectious measures on sepsis mortality: a cluster randomised trial....

Recommended Reading from the University of Ottawa Nephrology Fellows David Massicotte-Azarniouch, Syed Obaid Amin, Caitlin Hesketh and Edward G. Clark AJRCCM Articles in Press. Published on 02-May-2017 as 10.1164/rccm.201611-2375RR Bitker L, et al.; Prevalence and risk factors of hypotension associated with preload-dependence during intermittent hemodialysis in critically ill patients. Crit Care (10) Reviewed by Caitlin Hesketh Intradialytic hypotension (IDH) is a common ...

Recommended Reading from the University of Ottawa Nephrology Fellows David Massicotte-Azarniouch, Syed Obaid Amin, Caitlin Hesketh and Edward G. Clark AJRCCM Articles in Press. Published on 02-May-2017 as 10.1164/rccm.201611-2375RR Zarbock et al. Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial. JAMA (6) Reviewed by Syed Obaid Amin The Effect of Early vs...

Recommended Reading from the University of Ottawa Nephrology Fellows David Massicotte-Azarniouch, Syed Obaid Amin, Caitlin Hesketh and Edward G. Clark AJRCCM Articles in Press. Published on 02-May-2017 as 10.1164/rccm.201611-2375RR Gaudry S, et al.; Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med (1) Reviewed by David Massicotte-Azarniouch Meta-analyses of mainly observational studies have shown relatively earlier initiation of...

Effect of laminar airflow ventilation on surgical site infections: a systematic review and meta-analysis Peter Bischoff, Peter Bischoff, N Zeynep Kubilay, et al Lancet Infect Dis 2017; 17: 553-561 DOI: http://dx.doi.org/10.1016/S1473-3099(17)30059-2 Summary Background 背景 The role of the operating room's ventilation system in the prevention of surgical site infections (SSIs) is widely discussed, and existing guidelines do not reflect current evidence. In this context, ...